Neutrophil to lymphocyte and platelet to lymphocyte ratio in patients with dipper versus non-dipper hypertension

Sünbül, Murat; Gerin, Fethullah; Durmuş, Erdal; Kıvrak, Tarık; Sarı, İbrahim; Tigen, Kürşat; Cincin, Altug

doi:10.3109/10641963.2013.804547

Cited by 182 publications

(179 citation statements)

References 26 publications

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“…They release several types of cytokines and trigger the immune system and infl ammatory reactions. Previous studies have demonstrated that higher levels of NLR are associated with impaired cardiovascular outcomes (10)(11)(12)(13). NLR is not only associated with CVD, but also associated with chronic renal disease and several malignancies (11,13,29,30).…”

Section: Discussionmentioning

confidence: 99%

“…The neutrophil to lymphocyte ratio (NLR) which can be derived from the white blood cell count is an inexpensive, routinely used, reproducible test. NLR has been proposed as a novel biomarker for systemic infl ammatory response in several diseases (10)(11)(12)(13). Previous studies have shown that NLR is associated with poor clinical outcomes in CVD and it is also a predictor for CVD (10,12).…”

Section: Introductionmentioning

confidence: 99%

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The association of neutrophil to lymphocyte ratio with presence and severity of obstructive sleep apnea

Sünbül¹,

Sünbül²,

Kanar³

et al. 2015

BLL

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BACKGROUND: Obstructive sleep apnea (OSA) is characterized by reductions in breathing amplitude during sleep caused by an obstructed or collapsed upper airway. The neutrophil to lymphocyte ratio (NLR) has been proposed as a novel biomarker for systemic infl ammatory response. The aim of the present study was to evaluate the relationship between NLR and OSA. METHODS: The study population consisted of 195 consecutive patients with clinical suspicion of OSA. Full night polysomnography was performed for all patients. Patients with an apnea hypopnea index (AHI) ≥ 5 were considered to have OSA. NLR was calculated as the ratio of neutrophil count to lymphocyte count. RESULTS: While 130 patients (91 male, mean age: 49.9±9.8 years) had OSA, 65 patients (42 male, mean age: 48.7 ± 10.2 years) had normal fi ndings according to AHI scores. Cardiovascular risk factors such as hypertension, hyperlipidemia, diabetes mellitus and smoking were more common in patients with OSA. Patients with OSA had signifi cantly higher NLR than controls (1.87±0.80 vs 1.49±0.48, p=0.005). AHI score was signifi cantly correlated with NLR (r=0.228, p=0.001). NLR and presence of hyperlipidemia were independent predictors of OSA (OR: 2.451, 2.850, p=0.001, 0.004, respectively). NLR of 1.62 or higher predicted OSA with a sensitivity of 56.2 % and specifi city of 63.1 %. CONCLUSIONS: NLR was higher and also correlated with AHI score in patients with OSA which has not been reported previously. NLR more than 1.62 was an independent predictor of OSA. A simple, cheap white blood cell count may also give an idea about the presence and severity of OSA (Tab. 3, Fig. 3, Ref. 30). Text in PDF www.elis.sk. KEY WORDS: infl ammation, cardiovascular risk, neutrophil to lymphocyte ratio, obstructive sleep apnea.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The association of neutrophil to lymphocyte ratio with presence and severity of obstructive sleep apnea

Sünbül¹,

Sünbül²,

Kanar³

et al. 2015

BLL

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“…PLR has been recently suggested to be a marker of thrombotic and inflammatory condition. In the literature, it was shown that valvular heart diseases, acute coronary syndromes, hypertension, end-stage renal diseases, and other diseases may potentially affect the PLR [2][3][4][5][6]. In the study of Xing Li et al [1], patients with previous and/or secondary cancers were excluded, while such as heart diseases which is very common in old people (age 57 (19-86)) were not mentioned.…”

mentioning

confidence: 99%

Platelet-to-lymphocyte ratio: a prognostic factor for patients with advanced hepatocellular carcinoma?

Tian

Zeng

2015

Tumor Biol.

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“…13 It causes not only cardiovascular disease, but also numerous chronic diseases such as cancers, diabetes mellitus, hypertension, connective tissue disease, and chronic kidney disease. [14][15][16][17][18] Figure 1: Receiver operating characteristic analysis for neutrophil-to-lymphocyte ratio to predict abnormal coronary angiography (area under curve is 0.726).…”

Section: Discussionmentioning

confidence: 99%

Association between neutrophil to lymphocyte ratio and severity of coronary artery disease

Jagadish

Manjunath

et al. 2018

Int J Adv Med

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Background: Atherosclerosis is a chronic systemic inflammatory disease. Neutrophil-to-lymphocyte ratio (NLR) is systemic inflammatory marker that is correlated with poor cardiovascular outcome. The aim of this study was to investigate the association between neutrophil to lymphocyte ratio (NLR) and severity of coronary atherosclerosis.Methods: A total of 324 patients undergoing coronary angiography were included in the study. All the patients were included in study were divided into two groups based on the result of coronary angiography report. While 226 patients had abnormal coronary angiography (case) (78 female, mean age: 60.6±12.6 years), 98 patients had normal coronary angiography (control) (60 female, mean age: 57.2±10.9 years). NLR was calculated as the ratio of neutrophil count to lymphocyte count.Results: Although age distribution was similar between the two groups(p = 0.073), female gender was significantly higher in the normal coronary angiography group (p < 0.001). Smoking history has shown a significant higher in cases compared to the normal coronary angiography (p=0.001). Patients with abnormal coronary angiography had significantly higher NLR when compared to patients with normal coronary angiography (p<0.001). NLR was significantly correlated with Gensini score. In logistic regression analyses, NLR was an independent predictor of CAD. An NLR of 2.34 or higher predicted the CAD with a sensitivity of 66% and specificity of 70%.Conclusions: There is significant association between severity of coronary artery disease and neutrophils to lymphocyte ratio. This study suggests that the NLR is an independent predictor of coronary heart disease that may be useful for cardiac risk stratification in patients with coronary artery disease.

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Neutrophil to lymphocyte and platelet to lymphocyte ratio in patients with dipper versus non-dipper hypertension

Abstract: We demonstrated that patients with non-dipper hypertension had significantly higher NLR and PLR compared to dipper hypertension, which has not been reported previously. Moreover PLR more than 107 but not NLR was independent predictor of non-dipper status.

Cited by 182 publications

References 26 publications

The association of neutrophil to lymphocyte ratio with presence and severity of obstructive sleep apnea

The association of neutrophil to lymphocyte ratio with presence and severity of obstructive sleep apnea

Platelet-to-lymphocyte ratio: a prognostic factor for patients with advanced hepatocellular carcinoma?

Association between neutrophil to lymphocyte ratio and severity of coronary artery disease

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