Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as biological markers of interest in kidney disease

Valga, Francisco; Monzón, Tania; Henríquez, Fernando; Antón-Pérez, Gloria

doi:10.1016/j.nefroe.2018.11.013

Cited by 19 publications

(22 citation statements)

References 55 publications

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“…It has been suggested that the PLR could be a good marker of inflammation in the population with CKD [10]. Several studies also showed a positive relationship between PLR values and disease severity.…”

Section: Discussionmentioning

confidence: 99%

Association Between Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio With 1-Year Mortality in Hemodialysis Patient in Wangaya Regional General Hospital

Sastrawan¹,

Shalim²

2019

Asian J Pharm Clin Res

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Objective: The aim of this study was to determine whether neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are associated with mortality risk in patients with hemodialysis (HD). Methods: We conducted a retrospective cohort study among regular HD patients at Wangaya Regional General Hospital. Data were collected from patients’ medical records in June 2018 and followed up until May 2019. Results: NLR and PLR were significantly associated with 1-year mortality (p=0.047 and p=0.009), with higher NLR (NLR>2.84) and higher PLR (PLR>10) associated with higher risk of 1-year mortality (relative risk [RR]=3.36 and RR=5.19). Conclusion: NLR and PLR were significantly associated with 1-year mortality in patients with HD.

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Section: Discussionmentioning

confidence: 99%

Association Between Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio With 1-Year Mortality in Hemodialysis Patient in Wangaya Regional General Hospital

Sastrawan¹,

Shalim²

2019

Asian J Pharm Clin Res

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“…The exposure variables were the neutrophil/lymphocyte ratio (NLR) and the platelet/lymphocyte ratio (PLR), defined as the quotient between neutrophil or platelet count and lymphocyte count. We calculated both ratios using the patient's complete blood count, and defined elevates NLR and PLR; as a cut-off point of 3.5 and 232.5; respectively (14). The primary outcome was mortality, which is a dependent variable composed of the probability of dying and the time until the development of the event.…”

Section: Variablesmentioning

confidence: 99%

“…Indeed, the contribution of interactions between neutrophils and platelets in infections and inflammatory processes have begun to be intensively studied (12,13). Specific lymphocyte subtypes, such as Th2 and regulatory T, decrease inflammation by different routes, such as GATA3 and FOXP3 (14). Therefore, the elevation of the NLR and PLR reflects a pro-inflammatory imbalance, as the effector cells are increased, and the regulatory cells are decreased.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio as a risk factor for mortality in peruvian adults with chronic kidney disease.

Umeres-Francia

Rojas-Fernández

Herrera-Añazco

et al. 2021

Preprint

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Objective: To assess the association between NLR and PLR with all-cause mortality in Peruvian patients with CKD Methods: We conducted a retrospective cohort study in adults with CKD in stages 1 to 5. The outcome variable was mortality and as variables of exposure to NLR and PLR. Both ratios were categorized as high with a cut-off point of 3.5 and 232.5; respectively. We carried out a Cox regression model and calculated crude and adjusted hazard ratios (HR) with their 95% confidence interval (95%CI). Results: We analyzed 343 participants with a median follow-up time of 2.45 years (2.08-3.08). The frequency of deaths was 17.5% (n=60). In the crude analysis, the high NLR and PLR were significantly associated with all-cause mortality (HR=2.01; 95% CI:1.11-3.66) and (HR=2.58; 95% CI:1.31-5.20). In the multivariate model, after adjusting for age, sex, serum creatinine, CKD stage, albumin and hemoglobin, the high NLR and PLR remained as an independent risk factor for all-cause mortality, (HR=2.10; 95% CI:1.11-3.95) and (HR=2.71; 95% CI:1.28-5.72). Conclusion: Our study suggests the relationship between high NLR and PLR with all-cause mortality in patients with CKD.

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“…Inflammation is one of the main pathophysiological factors in PCOS diseases. Nowadays diagnostic and monitoring markers are used, such as C-reactiveprotein (CRP), erythrocyte sedimentation rate, ferritin, serumalbumin, apolipoprotein A-1, tumor necrosis factor, interleukin-1, interleukin-6 and others (7,8) .Chronic inflammation and infection are an important and major cause of cancer,include NF-κB,reactive oxygen species and nitrogen, inflammatory cytokines,prostaglandins,andR NAs,through proliferation changes,cell death,cellular aging,mutation and methylation in DNA (7) .…”

Section: Introductionmentioning

confidence: 99%

“…Several biomarkers such as CRP, neutrophil-tolymphocyteratio (NLR) and platelet-to lymphocyte ratio (PLR) were used as markers of inflammation and endothelial damage (8,9) .Complete blood count (CBC) test is widely used,and mainly includes white blood cell (WBC) count, red blood cell (RBC) count and platelet count.WBCs most abundant in healthy individuals are neutrophils,which play important roles during acute and chronic inflammation and may be potential therapeutic targets in several diseases (10,11) . 8-Hydroxydeoxyguanosine (8-OHdG) can be a defense mechanism against oxidative stress and preventing inflammatory disease (12) .…”

Section: Introductionmentioning

confidence: 99%

Assessment of Neutrophil-to-Lymphocyte Ratio, Platelet-toLymphocyte Ratio,Oxidative Stress and Anti Oxidants levels in Polycystic Ovary Syndrome Patients with Low-Grade Chronic Inflammation

2021

MLU

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Background:The ratio of neutrophils to lymphocytes (NLR) and the ratio of platelets to lymphocytes (PLR)are prognostic factors in many diseases such as inflammatory diseases, cardiovascular diseases and cancer. However, racing NLR and PLR are important, it is important to establish reference values for NLR and PLR in polycystic ovary syndrome (PCOS) patients with mild chronic inflammation.Objective: To determine the neutrophil-lymphocyte ratio (NLR)and platelet-lymphocyte ratio (PLR), and the relationship between oxidative stress markers and anti oxidants markers in PCOS patients with lowgrade chronic Inflammation. Methodology. The study included 92 patients with PCOS and 46 control. Serum PON1, XO, SOD activities, 8-OHdG and NO levels were measured using enzyme linked immunosorbent assay (ELISA) kits.Results: Concentration of TNF-ɑ, IL-6, IL-8, IL-10 and CRP were significantly higher in PCOS patients compared with control (P<0.001). Significant increases were recorded in WBC, ANC, PLT, NLR, PLR, and ESR values. A significant decrease in ALC and MPV values in PCOS patients compared with control (P<0.01). Serum XO, SOD activities and NOlevels were higher in PCOS patients than in the control (p<0.001). Serum 8-OHdG levels and PON1 activities were lower in PCOS patients than in the control (p<0.001). Serum CRP values is positively correlated with XO, NO, p<0.008; r=0.560, p<0.007; r=0.387, p<0.006; r=0.481, p<0.009), respectively. Serum CRP values is negatively correlated with SOD activity in PCOS patients (r=−0.444, p<0.004).Serum XO activities were negatively correlated with serum PON1 and SOD. Serum XO activities were Positively correlated with serum NO and 8-OHdG levels. Conclusion:Inflammation stimulates the oxidation process and reduces the ability of cellular antioxidants in PCOS patients. NLR and PLR are good markers of inflammation, their highest values indicate the severity of the disease and an imbalance between neutrophils and lymphocytes can be linked to cancer and its development.

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Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as biological markers of interest in kidney disease

Cited by 19 publications

References 55 publications

Association Between Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio With 1-Year Mortality in Hemodialysis Patient in Wangaya Regional General Hospital

Association Between Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio With 1-Year Mortality in Hemodialysis Patient in Wangaya Regional General Hospital

Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio as a risk factor for mortality in peruvian adults with chronic kidney disease.

Assessment of Neutrophil-to-Lymphocyte Ratio, Platelet-toLymphocyte Ratio,Oxidative Stress and Anti Oxidants levels in Polycystic Ovary Syndrome Patients with Low-Grade Chronic Inflammation

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