Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios of overweight children and adolescents

Abstract

OBJECTIVE: This study aimed to compare neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio of overweight children and adolescents with the eutrophic ratios and to verify whether these ratios are associated with age, inflammation, Z-score of body mass index, and waist-to-height ratio. METHODS: This is a cross-sectional study involving 64 overweight and 106 eutrophic children and adolescents. Data on weight, height, and waist circumference (body mass index and waist-to-height ratio), blood count (neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio), and highsensitivity C-reactive protein were collected. RESULTS: The mean age of participants was 8.4±3.2 years. The ratios did not differ between the overweight and non-overweight groups. The plateletto-lymphocyte ratio has shown a direct and independent association with body mass index (p=0.031) and waist-to-height ratio (p=0.018), a fact not observed for neutrophil-to-lymphocyte ratio. The ultrasensitive C-reactive protein level was higher in the obesity group (p=0.003). Both ratios had a direct and independent association with age. CONCLUSION: The ratios did not differ between the overweight and non-overweight groups. There was a direct and independent association of platelet-to-lymphocyte ratio with overweight, not observed in neutrophil-to-lymphocyte ratio. The ratios have significantly increased according to the age of the participants.

Obez ve obez olmayan çocuklarda inflamatuar hematolojik parametrelerin karşılaştırılması

“…When we examine studies conducted on obese children, Anik et al reported that PLR is not different in obese adolescents compared to healthy controls [30]. Likewise, no difference was found in the study conducted by Yazaki et al [31].…”

Complete Blood Count-Derived Inflammation Indexes Are Useful in Predicting Metabolic Syndrome in Children and Adolescents with Severe Obesity

“…Mărginean et al [11] also found comparable NLR values between children and adolescents with obesity and normal-weight individuals. In a study performed on adolescents with obesity, Dilek et al [43] reported that PLR values were comparable between adolescents with obesity and healthy controls, while Yazaki et al [44] detected no correlation between NLR and BMI in their study of children with obesity. In contrast, Aydin et al [45] observed a significant increase in NLR and PLR values in adolescents with obesity compared to healthy controls.…”