Neutrophil to Lymphocyte Ratio and Mean Platelet Volume as Inflammatory Indicators in Systemic Lupus Erythematosus Nephritis

Ayna, Ata Bora; Ermurat, Selime; Coşkun, Belkıs Nihan; Harman, Halil; Pehlıvan, Yavuz

doi:10.5606/archrheumatol.2017.5886

Cited by 21 publications

(16 citation statements)

References 30 publications

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“…Higher MPV levels were reported in patients with renal involvement compared to patients without renal involvement. There have been statistically differences between both groups (23). There was a negative correlation between MPV and disease activity in SLE patients with renal involvement in our study.…”

Section: Discussioncontrasting

confidence: 39%

Mean platelet volume and renal involvement in patients with systemic lupus erythematosus

Sargın¹,

Şentürk²

2019

Kocaeli Med J

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ÖZAmaç: Amacımız, sistemik lupus eritematozuslu (SLE) hastalarda ortalama trombosit hacmi (MPV) ile renal tutulum arasındaki ilişkiyi belirlemektir. Ayrıca renal tutulumlu SLE hastalarında eritrosit sedimantasyon hızı (ESH), C-reaktif protein (CRP), kompleman bileşen 3 (C3), C4 ve hastalık aktivitesini başlangıçta ve tedavinin 6. ayında değerlendirmeyi amaçladık. Gereç veYöntemler: Çalışmaya SLE tanısı almış 85 hasta (4 erkek, 81 kadın, ortalama yaş 39,5±10,5 yıl) alındı. Yaş, cinsiyet, MPV, CRP, ESH, C3, C4 ve SLE hastalık aktivite indeksi (SLEDAI) değerlendirildi. Veriler Kolmogorov-Smirnov, Mann-Whitney, Wilcoxon testi ve Spearman korelasyonu ile değerlendirildi. Bulgular: MPV düzeyi, nefriti olmayan hastalarda nefriti olan hastalara göre daha yüksekti. Her iki grup arasında MPV açısından anlamlı farklılık yoktu. Böbrek tutulumu olan ve böbrek tutulumu olmayan SLE hastalarında MPV ile hastalık aktivitesi arasında korelasyon saptandı (sırasıyla, r=-0,396, p=0,04, r=-0,262, p=0,03). Sonuç:Böbrek tutulum olan ve olmayan lupus hastalarında hastalık aktivitesi ile MPV negatif korelasyon göstermektedir. MPV, SLE'li hastalarda hastalık aktivitesini ve organ tutulumunu değerlendirmede yardımcı olabilir. Yinede, bu konuyla ilgili uzun dönem sonuçları hakkında bilgiler sınırlıdır.Anahtar Kelimeler: sistemik lupus eritematozus, ortalama trombosit hacmi, böbrek tutulumu, sistemik lupus eritematozus hastalık aktivite indeksi ABSTRACT INTRODUCTION: Our aim is to determine the relationship between mean platelet volume (MPV) and renal involvement in patients with systemic lupus erythematosus (SLE). We also aimed to evaluate erythrocyte sedimentation rate (ESR), Creactive protein (CRP), complement component 3 (C3), C4, and disease activity at the baseline and 6th months of treatment in SLE patients with renal involvement. METHODS:A total of 85 SLE patients (4 male, 81 female, with the mean age of 39,5±10,5 years) who had been diagnosed with SLE were enrolled in the study. Age, gender, MPV, CRP, ESR, C3, C4, and SLE Disease Activity Index (SLEDAI) were evaluated. The data were assessed with Kolmogorov-Smirnov, Mann-Whitney, Wilcoxon test, and Spearman correlation. RESULTS:The levels of MPV were higher in patients without nephritis compared to patients with nephritis. There was no significant difference in MPV between both groups. We found a correlation between MPV and disease activity for SLE patients with renal involvement and without renal involvement (r=-0,396, p=0.04, r=-0.278, p=0.03, respectively). DISCUSSION and CONCLUSION:MPV is negatively correlated with disease activity in lupus patients with renal involvement and without renal involvement. MPV may be helpful to assess disease activity and organ-involvement in patients with SLE. the knowledge about long-term results about this topic is limited.

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Section: Discussioncontrasting

confidence: 39%

Mean platelet volume and renal involvement in patients with systemic lupus erythematosus

Sargın¹,

Şentürk²

2019

Kocaeli Med J

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“…During the full-text review process, four studies were further excluded for lacking the data of interest. Finally, 14 studies with 1,781 SLE patients and 1,330 healthy controls were included in this meta-analysis (22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35).…”

Section: Study Selectionmentioning

confidence: 99%

“…The synthesized result showed that an increased NLR was closely associated with active SLE (SMD=2.05; 95% CI, 0.87-3.23) ( Figure 3). Additionally, four studies of 441 patients explored the difference in NLR between SLE patients with versus without lupus nephritis (22,23,25,26). Considering the lack of significant heterogeneity (I 2 =0.0%, p=0.876), we conducted the synthesized analysis of the four studies using a randomeffects model.…”

Section: Synthesized Analysismentioning

confidence: 99%

Relationship between Neutrophil-to-Lymphocyte Ratio and Systemic Lupus Erythematosus: A Meta-analysis

Wang¹,

Wang²,

Jia³

et al. 2020

Clinics

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Systemic lupus erythematosus (SLE) is a chronic systematic autoimmune disease. Current methods of diagnosing SLE or evaluating its activity are complex and expensive. Numerous studies have suggested that neutrophil-tolymphocyte ratio (NLR) is closely correlated with the presence of SLE and its activity, suggesting that it may serve as a diagnostic and monitoring indicator for SLE. Therefore, we performed a meta-analysis to systematically assess the association between NLR and SLE. We performed a literature search until 12 April 2019 in the PubMed, Web of Science, and China National Knowledge Infrastructure databases. Cross-sectional studies comparing the NLR of SLE patients versus those of healthy controls, of active versus inactive SLE patients, and of SLE patients with versus without lupus nephritis were considered for inclusion. Mean intergroup NLR differences were estimated using standardized mean differences and their 95% confidence intervals. Study quality was assessed using the Agency for Healthcare Research and Quality instrument for cross-sectional studies. Fourteen studies with 1,781 SLE patients and 1,330 healthy controls were included in this meta-analysis. The pooled results showed that the NLR was significantly higher in SLE patients than in healthy controls, in active SLE patients than in inactive SLE patients, and in SLE patients with lupus nephritis than in those without lupus nephritis. NLR may be an indicator for monitoring disease activity and reflecting renal involvement in SLE patients. Nevertheless, more high-quality studies are warranted to further validate our findings.

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“…One of these was excluded because they included other diseases [31]. Thus, nine articles met the inclusion criteria [3,[10][11][12][13][14][15][16][17] (Table 1, Figure 1). One report contained data on two different groups [12], so we analyzed these studies independently.…”

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

“…Studies on NLR, PLR, and MPV in SLE patients compared to healthy controls, on the relationship between NLR, PLR, and MPV levels and SLE activity, and on the association of NLR with renal involvement in SLE have reported controversial results [3,[10][11][12][13][14][15][16][17]. This may be because of the small sample sizes, low statistical power, and/or the presence of clinical heterogeneity.…”

Section: Introductionmentioning

confidence: 99%

Association of Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, and Mean Platelet Volume with Systemic Lupus Erythematosus Disease Activity: A Meta-analysis

Lee

Song

2017

J Rheum Dis

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Objective. A series of common blood tests neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and mean platelet volume (MPV) could provide a measure of systemic lupus erythematosus (SLE) activity. Methods. We searched the Medline, Embase, and Cochrane databases and performed a meta-analysis comparing NLR, PLR, and MPV in patients with SLE to controls, and examined correlation coefficients between NLR, PLR, and MPV and SLE activity based on SLE Disease Activity Index (SLEDAI) using random-effects models. Results. Nine studies were included in this meta-analysis. Meta-analysis revealed that NLR was significantly higher in the SLE group than in the control group (standard mean difference [SMD]=2.747, 95% confidence interval [CI]=1.241∼4.254, p＜0.001). PLR was also significantly higher in the SLE group (SMD=1.564, 95% CI=0.122∼3.006, p=0.034). Meta-analysis of correlation coefficients showed that both NLR and PLR were positively associated with SLEDAI (correlation coefficient=0.404, 95% CI=0.299∼0.500, p＜0.001; correlation coefficient=0.378, 95% CI=0.234∼0.505, p＜0.001). The pooled sensitivity and specificity of NLR for diagnosis of lupus nephritis were 75.1% (95% CI, 68.5∼81.0) and 72.9% (95% CI, 64.9∼80.0), respectively. The area under the curve of NLR were 0.794. However, meta-analysis indicated no elevated MPV in the SLE group and no correlation between MPV and SLE activity. Conclusion. This meta-analysis demonstrated that both NLR and PLR are higher in patients with SLE, a significantly positive correlation exists between NLR/PLR and SLE activity. (J Rheum Dis 2017;24:279-286)

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Neutrophil to Lymphocyte Ratio and Mean Platelet Volume as Inflammatory Indicators in Systemic Lupus Erythematosus Nephritis

Cited by 21 publications

References 30 publications

Mean platelet volume and renal involvement in patients with systemic lupus erythematosus

Mean platelet volume and renal involvement in patients with systemic lupus erythematosus

Relationship between Neutrophil-to-Lymphocyte Ratio and Systemic Lupus Erythematosus: A Meta-analysis

Association of Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, and Mean Platelet Volume with Systemic Lupus Erythematosus Disease Activity: A Meta-analysis

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