Neutrophil to lymphocyte ratio and in-hospital mortality among patients with SARS-CoV-2: A retrospective study

Al-Mazedi, Maryam Salah; Rajan, Rajesh; Al‐Jarallah, Mohammed; Dashti, Raja; Saber, Ahmad Al; Pan, Jiazhu; Kobalava, Zh. D.; Abdelnaby, Hassan; Aboelhassan, Wael; Almutairi, Farah; Alotaibi, Naser; Saleh, Marwa; AlNasrallah, Noor; Al‐Bader, Bader; Malhas, Haya; Ramadhan, Maryam; Brady, Peter A.; Al‐Zakwani, Ibrahim; Setiya, Parul; Abdullah, Mohammed; Alroomi, Moudhi; Tse, Gary

doi:10.1016/j.amsu.2022.104748

Cited by 9 publications

(11 citation statements)

References 40 publications

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“…In the first day the difference among the two groups were more pronounced that second day; however, both associations were not significant ( p = 0.099 & p = 0.824). This finding in our study contradicts some of the other studies to date 7,9,10,17,24 . Furthermore, we did not discover any relationship between the sex of the patients and the presence of neurological symptoms.…”

Section: Discussioncontrasting

confidence: 99%

“…This finding in our study contradicts some of the other studies to date. 7 , 9 , 10 , 17 , 24 Furthermore, we did not discover any relationship between the sex of the patients and the presence of neurological symptoms. Notably, we observed that younger children were more susceptible to present with neurological complications.…”

Section: Discussioncontrasting

confidence: 67%

“…It also discusses its association with sex, weight, age, and neutrophil to lymphocyte ratio (NLR). We chose NLR, because it has been shown to be prognostic in many acute conditions such as cancer, 7,8 sepsis, 9–13 surgery, 14–16 and even Covid‐19 17 …”

Section: Introductionmentioning

confidence: 99%

“…We chose NLR, because it has been shown to be prognostic in many acute conditions such as cancer, 7,8 sepsis, [9][10][11][12][13] surgery, [14][15][16] and even Covid-19. 17…”

mentioning

confidence: 99%

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Incidence of neurological complications following pediatric heart surgery and its association with neutrophil‐to‐lymphocyte ratio

Abdshah

Mirzaaghayan

Heidari

et al. 2023

Health Science Reports

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Background and Aims Due to increased rate of open‐heart surgeries in children, postsurgical mortality and morbidities have increasingly gained attention. Neurological complications are some of the most important postsurgical events. However, the number of studies regarding postsurgical neurological complications seems to be inadequate. We aimed to study the incidence of neurological complications following cardiac surgery in the pediatric cardiac intensive care unit (ICU) of the children's medical center. Methods This cross‐sectional study was conducted from March to September 2019. We included all of the children who underwent cardiac surgery and were admitted to ICU at CMC. We collected their demographic data, lab test results (white blood cell count, absolute neutrophile and lymphocyte counts) and calculated their Risk Adjustment for Congenital Heart Surgery (RACHS) score. We then documented neurological adverse events and investigated the associations between those events and the patients' data. Results Of the 267 studied patients, 14 developed neurological complications (5.2%); seven developed chorea (2.6%), four developed seizures (1.5%), and two developed both seizure and chorea (0.7%). One case developed subarachnoid hemorrhage (SAH). We observed that age ( p = 0.000), weight ( p = 0.000), and RACHS score ( p = 0.006) were associated with the development of neurological complications. Additionally, we observed that “neutrophil to lymphocyte ratio” was not associated with the risk of postsurgical neurological complications. Conclusion Younger age, lower weight, and higher RACHS score were associated with neurological complications after operations. Given the importance of postsurgical neurological complications, further investigations should be carried out to cover this issue and discover preventive strategies for such morbidities.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

“…We chose NLR, because it has been shown to be prognostic in many acute conditions such as cancer, 7,8 sepsis, [9][10][11][12][13] surgery, [14][15][16] and even Covid-19. 17…”

mentioning

confidence: 99%

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Incidence of neurological complications following pediatric heart surgery and its association with neutrophil‐to‐lymphocyte ratio

Abdshah

Mirzaaghayan

Heidari

et al. 2023

Health Science Reports

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“…Several studies have already highlighted that severely ill COVID-19 patients usually display a sustained increase in NLR at admission as a direct consequence of the hyperinflammatory and immunosuppressive state caused by the viral infection [ 36 , 71 , 73 , 78 , 79 , 80 ]. Even though there is no consensus about the NLR cut-off to be used in COVID-19 patients’ triage, as its value is known to be influenced by age, ethnicity, and comorbidities [ 72 , 74 , 77 ], it is noteworthy that it represents an objective parameter for the purpose of identifying those patients needing a close clinical monitoring early and for monitoring their clinical evolution, especially in those situations where the available clinical resources are scarce.…”

Section: Currently Validated Biomarkers In Clinical Practicementioning

confidence: 99%

COVID-19 Biomarkers at the Crossroad between Patient Stratification and Targeted Therapy: The Role of Validated and Proposed Parameters

Rizzi

D’Onghia

Tonello

et al. 2023

IJMS

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Clinical knowledge about SARS-CoV-2 infection mechanisms and COVID-19 pathophysiology have enormously increased during the pandemic. Nevertheless, because of the great heterogeneity of disease manifestations, a precise patient stratification at admission is still difficult, thus rendering a rational allocation of limited medical resources as well as a tailored therapeutic approach challenging. To date, many hematologic biomarkers have been validated to support the early triage of SARS-CoV-2-positive patients and to monitor their disease progression. Among them, some indices have proven to be not only predictive parameters, but also direct or indirect pharmacological targets, thus allowing for a more tailored approach to single-patient symptoms, especially in those with severe progressive disease. While many blood test-derived parameters quickly entered routine clinical practice, other circulating biomarkers have been proposed by several researchers who have investigated their reliability in specific patient cohorts. Despite their usefulness in specific contexts as well as their potential interest as therapeutic targets, such experimental markers have not been implemented in routine clinical practice, mainly due to their higher costs and low availability in general hospital settings. This narrative review will present an overview of the most commonly adopted biomarkers in clinical practice and of the most promising ones emerging from specific population studies. Considering that each of the validated markers reflects a specific aspect of COVID-19 evolution, embedding new highly informative markers into routine clinical testing could help not only in early patient stratification, but also in guiding a timely and tailored method of therapeutic intervention.

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Research Progress of Neutrophil to Lymphocyte Ratio and Viral Infectious Diseases

李¹

2023

ACM

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Neutrophil to lymphocyte ratio and in-hospital mortality among patients with SARS-CoV-2: A retrospective study

Cited by 9 publications

References 40 publications

Incidence of neurological complications following pediatric heart surgery and its association with neutrophil‐to‐lymphocyte ratio

Incidence of neurological complications following pediatric heart surgery and its association with neutrophil‐to‐lymphocyte ratio

COVID-19 Biomarkers at the Crossroad between Patient Stratification and Targeted Therapy: The Role of Validated and Proposed Parameters

Research Progress of Neutrophil to Lymphocyte Ratio and Viral Infectious Diseases

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