Neutrophil-to-lymphocyte ratio and neurological deterioration following acute cerebral hemorrhage

Lattanzi, Simona; Cagnetti, Claudia; Provinciali, Leandro; Silvestrini, Mauro

doi:10.18632/oncotarget.15423

Cited by 117 publications

(108 citation statements)

References 29 publications

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“…The NLR in peripheral blood has not only been proved to be one of the definitive markers of chronic inflammation in the cardiovascular system, it is also a reliable predictor of functional recovery after vascular disease. Furthermore, this index is easy to measure in clinical practice [16-18]. Moreover, the PLR is closely correlated with peripheral arterial occlusion diseases such as arteriosclerosis and arterial thrombosis [8].…”

Section: Discussionmentioning

confidence: 99%

Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Patients with Sudden Sensorineural Hearing Loss

Qiao

Wang

et al. 2018

Med Princ Pract

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Objective: Sudden sensorineural hearing loss (SSNHL) is a common acute disease with an incidence of 0.5–2/10,000. This study aimed to determine whether the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) could be indicators for SSNHL. Methods: A total of 60 confirmed cases of SSNHL and 60 healthy volunteers were included in this study. Peripheral blood NLRs and PLRs were compared between these groups. The SSNHL patients were divided into two groups, according to therapeutic effect: an effective group and an ineffective group. Peripheral blood NLRs and PLRs before and after treatment were compared between these two groups. Results: The average NLRs and PLRs of these patients were both significantly higher than in controls. The average NLRs and PLRs of the ineffective group were both significantly higher than those of the effective group. Conclusion: Peripheral blood NLR and PLR could be used as a convenient, reliable, and cost-effective indicator to predict the prognosis of SSNHL.

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Section: Discussionmentioning

confidence: 99%

Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Patients with Sudden Sensorineural Hearing Loss

Qiao

Wang

et al. 2018

Med Princ Pract

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“…During recent years, neutrophil‐to‐lymphocyte ratio (NLR) has been proved of great value with a significant correlation with systemic inflammation reaction in several autoimmune diseases . Because NLR can be easily obtained at low cost through an automatic hematology analyzer, many research groups have further confirmed the value of NLR in predicting disease severity and worse clinical outcomes in a variety of diseases, including cerebrovascular diseases, cardiovascular diseases, and neoplasm . Besides, cumulative evidence has suggested that NLR was associated with AP and better than other serum markers in predicting severity and prognosis of AP.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil‐to‐lymphocyte ratio can specifically predict the severity of hypertriglyceridemia‐induced acute pancreatitis compared with white blood cell

Huang

Chen

Yang

et al. 2019

Clinical Laboratory Analysis

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Objectives We aimed to evaluate the values of neutrophil‐to‐lymphocyte ratio (NLR) and white blood cell (WBC) in predicting severity of acute pancreatitis (AP) with different etiologies. Methods We compared NLR and WBC levels in patients with different etiologies and AP severity. The optimal cutoff value for them to predict severe acute pancreatitis (SAP) was determined by receiver operating characteristic (ROC) curve analysis. Results Both NLR and WBC were elevated in patients with SAP. After subgrouping AP by etiology, NLR was predictive of SAP only in hypertriglyceridemia‐induced AP (HTG‐AP), while WBC could effectively predict severity in both gallstone and HTG‐AP. The best cutoff value of WBC for predicting SAP in gallstone AP patients was 12.81 × 109/L, with sensitivity and specificity of 78.9% and 70.2%. The best cutoff value for NLR and WBC to differentiate HTG‐SAP was more than 5.88 and 15.89 × 109/L, respectively, with sensitivity and specificity of 87% and 50% for NLR and 56.5% and 75.76% for WBC. Conclusions Our study firstly demonstrated that NLR selectively played a role in HTG‐AP, while WBC could predict the severity of both gallstone and HTG‐AP. Furthermore, we firstly elucidated that NLR was more sensitive and accurate in judging the severity of HTG‐AP compared with WBC.

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“…In recent years, studies on the serological parameters for the early diagnosis of different diseases have become an area of focus. Some previous studies demonstrated that neutrophil‐to‐lymphocyte ratio of the patients was associated with the diagnosis and outcome of different diseases, including acute cerebrovascular diseases . On the other hand, the neutrophil‐to‐white blood cell ratio (NE/WBC) or platelet‐to‐white blood cell ratio (PLT/WBC) was significantly increased in patients with different type of diseases, for example, cancer, cardiovascular disease, and autoimmune diseases, suggesting that either NE/WBC or PLT/WBC may serve as novel biomarkers for the early diagnosis of those diseases …”

Section: Introductionmentioning

confidence: 99%

Maternal peripheral blood platelet‐to‐white blood cell ratio and platelet count as potential diagnostic markers of histological chorioamnionitis‐related spontaneous preterm birth

Li-yin

Pan

Rong-lian

et al. 2019

Clinical Laboratory Analysis

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Background Histological chorioamnionitis (HCA) is one of the leading causes of spontaneous preterm birth, thus, to identify novel biomarkers for the early diagnosis of HCA is in a great need. Objective To investigate the diagnostic value of maternal peripheral blood platelet‐to‐white blood cell ratio (PLT/WBC) and platelet (PLT) counts in HCA‐related preterm birth. Methods A total of 400 patients with preterm birth were enrolled in this study: non‐HCA group (n = 193) and HCA group (n = 207), and 87 full‐term pregnancies were enrolled as the control. The peripheral blood of the participators was collected, and the neutrophil count, WBC count, platelet count, and levels of C‐reactive protein (CRP) and procalcitonin were recorded, and the platelet‐to‐white blood cell ratio (PLT/WBC) of the participators was calculated. Receiver operating characteristic (ROC) curve has been drawn to show the sensitivity and specificity of PLT/WBC and PLT count for the diagnosis of HCA‐related spontaneous preterm birth patients. Results The neutrophil count, WBC count, and procalcitonin show no significant differences among the three groups, and the PLT count, PLT/WBC, and CRP (P < 0.05) were significantly increased in HCA group compared with non‐HCA group; moreover, the area under the curve (AUC) of PLT/WBC, PLT, and CRP was 0.744 (95% confidence interval [CI], 0.6966‐0.7922), 0.8095 (95% CI, 0.7676‐0.8514), and 0.5730 (95% CI, 0.5173‐0.6287), respectively. Conclusion Platelet count and PLT/WBC may become a potential biomarker of HCA‐related spontaneous preterm birth.

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Neutrophil-to-lymphocyte ratio and neurological deterioration following acute cerebral hemorrhage

Cited by 117 publications

References 29 publications

Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Patients with Sudden Sensorineural Hearing Loss

Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Patients with Sudden Sensorineural Hearing Loss

Neutrophil‐to‐lymphocyte ratio can specifically predict the severity of hypertriglyceridemia‐induced acute pancreatitis compared with white blood cell

Maternal peripheral blood platelet‐to‐white blood cell ratio and platelet count as potential diagnostic markers of histological chorioamnionitis‐related spontaneous preterm birth

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