Neutrophil to Lymphocyte Ratio as Prognostic Indicator for Patients with Esophageal Squamous Cell Cancer

Abstract

Pretreatment NLR is independently associated with OS of ESCC patients. Therefore, NLR may be used as a predictive indicator for pretreatment evaluation and adjustment of treatment regimen.

The clinical use of pretreatment NLR, PLR, and LMR in patients with esophageal squamous cell carcinoma: evidence from a meta-analysis

“… 16 , 20 , 22 , 24 – 26 All the included studies were carried out in Asia (15 studies in China, 10 studies in Japan, and only one study in Korea). The sample size of 16 studies was >200, 14 , 15 , 17 , 18 , 20 , 22 , 24 – 26 , 29 – 34 , 37 and the remaining 10 studies involved <200 patients. 16 , 19 , 21 , 23 , 27 , 28 , 35 , 36 , 38 , 39 Thirteen studies reported both survival and clinicopathological data, 15 , 16 , 20 , 22 – 26 , 31 – 34 , 37 and the other 13 studies only reported survival data.…”

C‐reactive protein/albumin ratio is a poor prognostic factor of esophagogastric junction and upper gastric cancer

“…These biomarkers can be evaluated easily by sampling a small amount of peripheral blood. Prognostic significance has been gradually elucidated by accumulation of data from studies in gastrointestinal tumors such as esophageal cancer, gastric cancer, and colorectal cancer . However, few studies about the relationship between these biomarkers with respect to prognosis in patients with AEG have been published.…”

“…Prognostic significance has been gradually elucidated by accumulation of data from studies in gastrointestinal tumors such as esophageal cancer, gastric cancer, and colorectal cancer. [17][18][19][20][21][22][23][24][25] However, few studies about the relationship between these biomarkers with respect to prognosis in patients with AEG have been published. In patients with AEG, pre-Alb, 33 body mass index, and NLR 34 were reported as independent prognostic factors.…”

“…We previously reported that skeletal muscle loss was strongly associated with a poor long‐term prognosis in patients who underwent surgical treatment of AEG and UGC . Also, several common inflammation‐based prognostic scores, including the neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR), Glasgow Prognostic Score (GPS), and controlling nutritional status (CONUT) score have been reported to have prognostic value in patients with many types of malignant, solid tumors . The C‐reactive protein (CRP)/albumin (Alb) ratio has also been reported as a novel inflammation‐based prognostic marker in multiple types of tumors, including hepatocellular carcinoma, colorectal cancer, esophageal cancer, renal cancer, pancreatic cancer, and gastric cancer …”

“…14 Also, several common inflammation-based prognostic scores, including the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), Glasgow Prognostic Score (GPS), and controlling nutritional status (CONUT) score have been reported to have prognostic value in patients with many types of malignant, solid tumors. 7,[15][16][17][18][19][20][21][22][23][24][25] The C-reactive protein (CRP)/albumin (Alb) ratio has also been reported as a novel inflammation-based prognostic marker in multiple types of tumors, including hepatocellular carcinoma, colorectal cancer, esophageal cancer, renal cancer, pancreatic cancer, and gastric cancer. 21,[26][27][28][29][30][31] In the present study, we investigated the prognostic value of the CRP/Alb ratio in patients who underwent surgery for AEG and UGC.…”