Neutrophil-to-lymphocyte ratio as a possible indicator of epicardial adipose tissue in patients undergoing hemodialysis

Özçiçek, Adalet; Yıldız, Gürsel; Timuroğlu, Aysu; Demirtaş, Levent; Büyüklü, Mutlu; Kuyrukluyıldız, Ufuk; Akbas, Emin Murat; Topal, Ergün; Türkmen, Kültiğin

doi:10.5114/aoms.2015.50784

Cited by 24 publications

(22 citation statements)

References 40 publications

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“…In our study, the optimal NLR cut-off value in distinguishing between patients in Group 1 and patients in Group 2 was ≥ 3.48 and showed a moderate sensitivity (63%) and good specificity (74%). Our results are in agreement with the findings of Sevim et al [20], who found an optimal NLR cutoff value of 3.5 and good sensitivity (76.6%) and low specificity (59.3%) in distinguishing patients with and without AA. Bialas et al [25] investigated the usefulness of the NLR value in the diagnosis of appendicitis in the adult population.…”

Section: Or -Odds Ratio CI -Confidence Interval Wbc -White Blood Cesupporting

confidence: 93%

Could the neutrophil-to-lymphocyte ratio serve as a marker in the diagnosis and prediction of acute appendicitis complications in children?

et al. 2019

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Introduction: Acute appendicitis (AA) is the most common surgical condition of the abdomen in children. The aim of this study was to analyse the possible use of the neutrophil-to-lymphocyte ratio (NLR) in the diagnosis and prediction of AA complications in children. Material and methods: We included 170 AA patients under 15 years of age, who were divided into the following groups: Group 1-non-operated patients with AA, and Group 2-patients who underwent appendectomy. Based on pathologic grades of AA, Group 2 was subdivided into: Group A-phlegmonous, Group B-gangrenous, and Group C-perforated AA. NLR was calculated as the absolute neutrophil count divided by the absolute lymphocyte count. Results: In Group 2 NLR was significantly higher than in Group 1 (5.5 [1.9-9.9] vs. 2.3 [1.2-3.7]; p < 0.001). A significant difference in NLR was found between Group C and Group A (p < 0.001), and as well as between Group B and Group A (p = 0.001). The determined optimal cutoff value of NLR in differentiating Group 1 vs. Group 2 was ≥ 3.48 (p < 0.001). In differentiating Group A from Group C the optimal cutoff value of NLR was ≥ 5.61 (p < 0.001). Furthermore, optimal cutoff value of NLR in differentiating Group A from Group B was ≥ 5.45 (p = 0.001). Conclusions: The obtained results suggest that NLR could be used as a simple and reliable test in the diagnosis and prediction of AA complications in children. However, to draw definite conclusions on the predictive power of NLR as a marker of AA large multicentric studies are required.

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Section: Or -Odds Ratio CI -Confidence Interval Wbc -White Blood Cesupporting

confidence: 93%

Could the neutrophil-to-lymphocyte ratio serve as a marker in the diagnosis and prediction of acute appendicitis complications in children?

et al. 2019

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“…Considering the number and the heterogeneity of RCC prognostic factors and the interactions between renal cell carcinoma and immune cells, searching for widely available and reliable inflammatory biomarkers seems essential [7,9]. Up to now, numerous studies have reported that some non-specific indicators derived from complete blood count (CBC) give added prognostic value in the assessment of various diseases, including renal cell carcinoma [10][11][12][13][14][15][16]. Amongst the most promising indices that are based on absolute values of circulating inflammatory cells, platelet-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), derived neutrophil-lymphocyte ratio (dNLR) and lymphocyte-monocyte ratio (LMR) are being particularly deeply investigated.…”

Section: Introductionmentioning

confidence: 99%

Novel hematological biomarkers predict survival in renal cell carcinoma patients treated with nephrectomy

Rajwa¹,

Życzkowski²,

Paradysz³

et al. 2020

aoms

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Introduction The association between novel blood-based inflammatory indices and patient survival has been reported with reference to various cancers. The aim of this study was to investigate the prognostic value of preoperative platelet-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), derived neutrophil-lymphocyte ratio (dNLR) and lymphocyte-monocyte ratio (LMR) in patients with renal cell carcinoma (RCC) treated with nephrectomy. Material and methods From 2003 to 2012, 455 patients who underwent partial or radical nephrectomy for RCC were enrolled in the study. The study endpoints were overall survival (OS) and cancer-specific survival (CSS). Results The median follow-up was 70 months. Groups of patients with high levels of PLR, NLR and dNLR and a low level of LMR more often underwent radical nephrectomy, had a higher cancer stage in the TNM classification, and were more frequently diagnosed with tumor necrosis in histopathological examination. Both cancer-specific mortality and overall mortality were significantly higher in patients with high PLR, NLR and dNLR and low LMR. Multivariate analysis of CSS, adjusted for standard clinicopathological factors, identified only dNLR ( p = 0.006) as an independent prognostic factor. PLR ( p = 0.0002), dNLR ( p = 0.0003) and NLR ( p = 0.002), but not LMR ( p = 0.1), achieved prognostic significance in multivariable analysis regarding OS. Conclusions Only dNLR was an independent prognostic factor for CSS and OS. Nevertheless, our study indicates that all examined complete blood count-based biomarkers may be useful tools in managing RCC patients treated with a surgical approach.

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“…Neutrophil-to-lymphocyte ratio (NLR) increases with increasing severity of inflammatory response and has been associated with poor patient outcomes in cancers (Grenader et al 2016 ; Ojerholm et al 2017 ), cardiovascular diseases (Kurtul et al 2016 ; Sari et al 2015 ), ischemic diseases (Aktimur et al 2016 ; Qun et al 2017 ), and a variety of other conditions (Ozcicek et al 2017 ; Pan et al 2017 ; Senturk et al 2016 ). A recent study from this research group (Wang et al 2016 ) showed an association of high NLR with 30-day mortality in ICH patients.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil-to-Lymphocyte Ratio Is an Independent Predictor of 30-Day Mortality of Intracerebral Hemorrhage Patients: a Validation Cohort Study

Wang

Jiang

et al. 2018

Neurotox Res

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In a previous study in patients with intracranial hemorrhage (ICH), we found an association between high neutrophil-to-lymphocyte ratio (NLR) with poor short-term mortality. In the current study, this preliminary finding was validated using an independent patient cohort. A total of 181 ICH patients (from January 2016 to December 2017) were included. Diagnosis was confirmed using computed tomography (CT) in all cases. Patient survival (up to 30 days) was compared between subjects with high NLR (above the 7.35 cutoff; n = 74) versus low NLR (≤ 7.35; n = 107) using Kaplan-Meier analysis. A multivariate logistic regression was performed to identify factors that influenced the 30-day mortality. Correlation between NLR with other relevant factors (e.g., C-reactive protein (CRP) and fibrinogen) was examined using Spearman correlation analysis. The 30-day mortality was 19.3% (35/181) in the entire sample, 37.8% (28/74) in the high-NLR group, and 6.5% (7/107) in the low-NLR group (P < 0.001). In comparison to the low-NLR group, the high-NLR group had higher rate of intraventricular hemorrhage (29.7 vs. 16.8%), ICH volume (median 23.9 vs. 6.0 cm3) and ICH score (median 1.5 vs. 0), and lower GCS score (9.4 ± 4.5 vs. 12.9 ± 3.2). An analysis that divided the samples into three equal parts based on NLR also showed increasing 30-day mortality with incremental NLR (1.6, 15.0, and 41.7% from lowest to highest NLR tertile, P for trend < 0.001). Kaplan-Meier curve showed higher 30-day mortality in subjects with high NLR than those with low NLR (P < 0.001 vs. low-NLR group, log-rank test). High NLR (> 7.35) is associated with poor short-term survival in acute ICH patients.

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Neutrophil-to-lymphocyte ratio as a possible indicator of epicardial adipose tissue in patients undergoing hemodialysis

Cited by 24 publications

References 40 publications

Could the neutrophil-to-lymphocyte ratio serve as a marker in the diagnosis and prediction of acute appendicitis complications in children?

Could the neutrophil-to-lymphocyte ratio serve as a marker in the diagnosis and prediction of acute appendicitis complications in children?

Novel hematological biomarkers predict survival in renal cell carcinoma patients treated with nephrectomy

Neutrophil-to-Lymphocyte Ratio Is an Independent Predictor of 30-Day Mortality of Intracerebral Hemorrhage Patients: a Validation Cohort Study

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