Neutrophil-to-lymphocyte ratio as a predictor of poor outcomes of Mycoplasma pneumoniae pneumonia

Li, Dan; Gu, Haiyan; Chen, Lei; Wu, Ruxi; Jiang, Yazhou; Huang, Xia; Zhao, Deyu; Liu, Feng

doi:10.3389/fimmu.2023.1302702

Cited by 11 publications

(4 citation statements)

References 28 publications

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“…Additionally, the caseonecrosis noted in the lungs and tonsils of bison in this study was characteristic of the clinical presentation noted in naturally occurring M. bovis infection of bison ( 11 , 12 , 32 ) and experimentally infected cattle ( 27 , 30 ). The elevated blood neutrophil counts observed in bison exhibiting severe disease is an interesting finding that has been previously shown to be associated with poor outcomes of pneumonia in humans and enhanced disease in mice with Mycoplasma pneumoniae ( 33 , 34 ), though has never been reported during M. bovis infection. Together these findings suggest that BHV-1, M. bovis coinfection can recapitulate the pathology observed in naturally infected bison which is similar to that observed in cattle.…”

Section: Discussionmentioning

confidence: 80%

An injectable subunit vaccine containing Elongation Factor Tu and Heat Shock Protein 70 partially protects American bison from Mycoplasma bovis infection

Kaplan,

Dassanayake,

Briggs

et al. 2024

Front. Vet. Sci.

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Mycoplasma bovis (M. bovis) is the etiologic agent of high mortality epizootics of chronic respiratory disease in American bison (Bison bison). Despite the severity of the disease, no efficacious commercial vaccines have been licensed for the prevention of M. bovis infection in bison. Elongation factor thermal unstable (EFTu) and Heat Shock Protein 70 (Hsp70, DnaK) are highly conserved, constitutively expressed proteins that have previously been shown to provide protection against M. bovis infection in cattle. To assess the suitability of EFTu and Hsp70 as vaccine antigens in bison, the immune response to and protection conferred by an injectable, adjuvanted subunit vaccine comprised of recombinantly expressed EFTu and Hsp70 was evaluated. Vaccinates developed robust antibody and cellular immune responses against both EFTu and Hsp70 antigens. To assess vaccine efficacy, unvaccinated control and vaccinated bison were experimentally challenged with bovine herpes virus-1 (BHV-1) 4 days prior to intranasal infection with M. bovis. Vaccinated bison displayed reductions in joint infection, lung bacterial loads, and lung lesions compared to unvaccinated controls. Together, these results showed that this subunit vaccine reduced clinical disease and bacterial dissemination from the lungs in M. bovis challenged bison and support the further development of protein subunit vaccines against M. bovis for use in bison.

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Section: Discussionmentioning

confidence: 80%

An injectable subunit vaccine containing Elongation Factor Tu and Heat Shock Protein 70 partially protects American bison from Mycoplasma bovis infection

Kaplan,

Dassanayake,

Briggs

et al. 2024

Front. Vet. Sci.

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“…The NLR is often relied on as a valuable tool to predict the prognosis of infectious diseases through monitoring systemic inflammation in children 22 . High levels of NLR are strongly linked to negative outcomes, so it is advisable to consider NLR as an unfavorable prognostic factor.…”

Section: Discussionmentioning

confidence: 99%

A preliminary study on the association between prognostic nutritional index and neutrophil-to-lymphocyte ratio with nutritional status and inflammation in febrile children's susceptibility to seizures

Çetin,

Çetin

2024

Rev. Assoc. Med. Bras.

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SUMMARY OBJECTIVE: The aim of this study was to evaluate the association between nutritional status, inflammation, and susceptibility to seizures in febrile children. METHODS: This observational single-center study was carried out from January 2020 to December 2023 with 324 children aged 6 months and 6 years; 106 were diagnosed with febrile seizure, 108 were febrile children, and 110 were healthy controls. The prognostic nutritional index and neutrophil-to-lymphocyte ratio were calculated, and the cutoff threshold was established through receiver operating characteristics. The study utilized correlation and univariate–multivariate logistic regression analysis. The comparison between simple and complex febrile seizure was conducted to analyze differences. RESULTS: The optimal cutoff values were identified as 61.25 for prognostic nutritional index and 1.04 for neutrophil-to-lymphocyte ratio. Our findings showed a significant negative association between febrile seizure and platelet count, high C-reactive protein, and high ferritin levels. Additionally, the febrile seizure group showed a significant positive correlation with high neutrophil-to-lymphocyte ratio values (≥1.04) and body temperature (≥38). Our findings revealed that high neutrophil-to-lymphocyte ratio, high C-reactive protein, and age less than 18 months were independently associated with seizure susceptibility in febrile children. CONCLUSION: High neutrophil-to-lymphocyte ratio values and low prognostic nutritional index scores may serve as novel surrogate independent factors for seizure susceptibility in febrile children. Febrile children who are less than 18 months old are more prone to experience seizures than older febrile children. Moreover, there was a correlation between febrile seizures and elevated C-reactive protein levels and neutrophil-to-lymphocyte ratio values.

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“…Mycoplasma pneumoniae (MP) is a common pathogen that causes lower respiratory tract infections in children 1 and cause up to 20 to 40% of community-acquired pneumonia 2 . In China, Mycoplasma pneumoniae pneumonia (MPP) accounts for about 32.4% of community-acquired pneumonia in children 3 .…”

Section: Introductionmentioning

confidence: 99%

“…Dan and colleagues investigated the potential of the peripheral blood neutrophil-to-lymphocyte ratio (NLR) to predict outcomes in patients with MPP. They found that Patients with a high NLR were more likely to develop NP and refractory Mycoplasma pneumoniae pneumonia (RMPP) and require intensive care, and had longer total fever duration, longer hospital stays, and higher hospitalization expenses than those with a low NLR 1 . The results suggested that the NLR can serve as a predictor of poor prognosis in patients with MPP and can predict the occurrence of NP, RMPP, and other poor outcomes.…”

Section: Introductionmentioning

confidence: 99%

Predictive value of lactate dehydrogenase for Mycoplasma pneumoniae necrotizing pneumonia in children based on decision curve analysis and dose–response analysis

Yanhong,

Shuai,

Dan

et al. 2024

Sci Rep

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Mycoplasma pneumoniae necrotizing pneumonia (MPNP) has a long and severe disease course, which seriously threatens to jeopardize patients' lives and health. Early prediction is essential for good recovery and prognosis. In the present study, we retrospect 128 children with MPNP and 118 children with Mycoplasma pneumoniae pneumonia combined with pulmonary consolidation to explore the predictive value of lactate dehydrogenase (LDH) in children with MPNP by propensity score matching method, multiple logistic regression analysis, dose–response analysis and decision curve analysis. The WBC count, PLT count and percentage of neutrophils were significantly higher in necrosis group than consolidation group. The serum CRP, PCT, ESR, D-D, FIB, ALT, LDH, IgG and IgM were significantly higher in necrosis group. Compared to consolidation group, necrosis group is more severe in chest pain and dyspnea. Multivariate logistic regression analysis showed that duration of LDH levels, high fever, d-dimer, and fibrinogen were independent predictive factors for the incidence of MPNP. Restricted cubic spline analysis showed that a non-linear dose–response relationship between the continuous changes of LDH level and the incidence of MPNP. Decision curve analysis revealed that LDH had an important clinical value in predicting MPNP. This study provides a potential serologic indicator for early diagnosis of MPNP.

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Neutrophil-to-lymphocyte ratio as a predictor of poor outcomes of Mycoplasma pneumoniae pneumonia

Cited by 11 publications

References 28 publications

An injectable subunit vaccine containing Elongation Factor Tu and Heat Shock Protein 70 partially protects American bison from Mycoplasma bovis infection

An injectable subunit vaccine containing Elongation Factor Tu and Heat Shock Protein 70 partially protects American bison from Mycoplasma bovis infection

A preliminary study on the association between prognostic nutritional index and neutrophil-to-lymphocyte ratio with nutritional status and inflammation in febrile children's susceptibility to seizures

Predictive value of lactate dehydrogenase for Mycoplasma pneumoniae necrotizing pneumonia in children based on decision curve analysis and dose–response analysis

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