Neutrophil-to-lymphocyte ratio as an independent factor for worse prognosis in radioiodine refractory thyroid cancer patients

Treistman, Natália; Cavalcante, Lara Bessa Campelo Pinheiro; Gonzalez, Fabiola; Fernandes, Pollyanna Iemini Weyll; Andrade, Fernanda Accioly de; Alves-Junior, Paulo Alonso Garcis; Corbo, Rossana; Bulzico, Daniel; Vaisman, Fernanda

doi:10.1007/s12020-023-03340-8

Cited by 4 publications

(2 citation statements)

References 43 publications

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“…Due to the short life of circulating neutrophils (20), most previous studies have identi ed the impact of neutrophils by neutrophil-to-lymphocyte ratio (NLR) in the peripheral blood, which correlates with poor prognosis or cancer development in advanced cancers (21). Especially in thyroid cancer, high baseline NLR were related with poor prognosis and have identi ed the predictive factor for radioactive iodine therapy (22,23,24,25). NLR is not only known to be increased in undifferentiated cancer compared to differentiated cancer, but can also be used as a prognostic biomarker associated with treatment response to lenvatinib(26, 27).…”

Section: Introductionmentioning

confidence: 99%

The role of neutrophil heterogeneity on T-cell immunity and prognosis in thyroid cancer patients

Kang,

Lee,

Koo

et al. 2024

Preprint

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Neutrophil heterogeneity is involved in autoimmune diseases, sepsis, and several cancers. However, the link between neutrophil heterogeneity and T-cell immunity in thyroid cancer is incompletely understood. We investigated the circulating neutrophil heterogeneity in 3 undifferentiated thyroid cancer (UTC), 14 differentiated thyroid cancer (DTC) (4 Stage IV, 10 Stage I-II), and healthy controls (n=10) by transcriptomic data and cytometry. Participants with UTC had a significantly higher proportion of immature high-density neutrophils (HDN) and lower proportion of mature HDN in peripheral blood compared to DTC. The proportion of circulating PD-L1+ immature neutrophils were significantly increased in advanced cancer patients. Unsupervised analysis of transcriptomics data from circulating HDN revealed downregulation of innate immune response and T cell receptor signaling pathway in cancer patients. Moreover, UTC patients revealed the upregulation of glycolytic process and glutamate receptor signaling pathway. Comparative analysis across tumor types and stages revealed the downregulation of various T cell related pathways, such as T cell receptor signaling pathway and T cell proliferation in advanced cancer patients. Moreover, the proportions of CD8+ and CD4+ T effector memory CD45RA+ (TEMRA) cells from peripheral blood were significantly decreased in UTC patients compared to DTC patients. Finally, we demonstrated that proportions of tumor infiltrated neutrophils were increased and related with poor prognosis in advanced thyroid cancer using data from our RNA-seq and TCGA (The Cancer Genome Atlas) data. In conclusion, observed prevalence of circulating immature high-density neutrophils and their immunosuppressive features in undifferentiated thyroid cancers underscore the importance of understanding neutrophil dynamics in the context of tumor progression in thyroid cancer.

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Section: Introductionmentioning

confidence: 99%

The role of neutrophil heterogeneity on T-cell immunity and prognosis in thyroid cancer patients

Kang,

Lee,

Koo

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Due to the short life of circulating neutrophils [ 20 ], most previous studies have identified the impact of neutrophils by neutrophil-to-lymphocyte ratio (NLR) in the peripheral blood, which correlates with poor prognosis or cancer development in advanced cancers [ 21 ]. Especially in thyroid cancer, high baseline NLR were related with poor prognosis and have identified the predictive factor for radioactive iodine therapy [ 22 – 25 ]. NLR is not only known to be increased in undifferentiated cancer compared to differentiated cancer, but can also be used as a prognostic biomarker associated with treatment response to lenvatinib [ 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Neutrophil diversity is associated with T-cell immunity and clinical relevance in patients with thyroid cancer

Lee,

Koo,

Sun

et al. 2024

Cell Death Discov.

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Neutrophil heterogeneity is involved in autoimmune diseases, sepsis, and several cancers. However, the link between neutrophil heterogeneity and T-cell immunity in thyroid cancer is incompletely understood. We investigated the circulating neutrophil heterogeneity in 3 undifferentiated thyroid cancer (UTC), 14 differentiated thyroid cancer (DTC) (4 Stage IV, 10 Stage I–II), and healthy controls (n = 10) by transcriptomic data and cytometry. Participants with UTC had a significantly higher proportion of immature high-density neutrophils (HDN) and lower proportion of mature HDN in peripheral blood compared to DTC. The proportion of circulating PD-L1+ immature neutrophils were significantly increased in advanced cancer patients. Unsupervised analysis of transcriptomics data from circulating HDN revealed downregulation of innate immune response and T-cell receptor signaling pathway in cancer patients. Moreover, UTC patients revealed the upregulation of glycolytic process and glutamate receptor signaling pathway. Comparative analysis across tumor types and stages revealed the downregulation of various T-cell-related pathways, such as T-cell receptor signaling pathway and T-cell proliferation in advanced cancer patients. Moreover, the proportions of CD8+ and CD4+ T effector memory CD45RA+ (TEMRA) cells from peripheral blood were significantly decreased in UTC patients compared to DTC patients. Finally, we demonstrated that proportions of tumor-infiltrated neutrophils were increased and related with poor prognosis in advanced thyroid cancer using data from our RNA-seq and TCGA (The Cancer Genome Atlas) data. In conclusion, observed prevalence of circulating immature high-density neutrophils and their immunosuppressive features in undifferentiated thyroid cancers underscore the importance of understanding neutrophil dynamics in the context of tumor progression in thyroid cancer.

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Neutrophil-To-Lymphocyte Ratio as a Prognostic Indicator in Thyroid Cancer

Gao,

Quan,

Zhang

et al. 2024

Cancer Control

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Objective In this study, we aimed to perform a comprehensive analysis to assess the prognostic value of neutrophil-to-lymphocyte ratio (NLR) levels in patients diagnosed with thyroid cancer. Methods We systematically searched multiple databases, including PubMed, the Cochrane Library, EMBASE, and Google Scholar, up until March 30, 2023, to identify relevant articles. The clinical outcomes evaluated in this study included overall survival (OS), progression-free survival (PFS), disease-free survival (DFS), and cause-specific survival (CSS). Results This analysis includes 21 articles with 5187 patients in total. The pooled results revealed that patients with high NLR levels had significantly poorer OS (HR: 2.578, 95% CI: 2.050-3.242, P < 0.001), PFS (HR: 2.143, 95% CI: 1.616-2.843, P < 0.001), DFS (HR: 1.377, 95% CI: 1.045-1.816, P = 0.023), and CSS (HR: 2.842, 95% CI: 1.334-6.053, P = 0.007). The subgroup analyses were performed based on different study regions, treatment modalities, cancer types, and NLR cut-off values, and the above conclusion remained consistent in the majority of subgroup analyses. The stability and reliability of the aforementioned results were supported by the sensitivity analysis and publication bias test. Conclusion The baseline NLR levels were useful predictors of outcomes in patients with thyroid cancer.

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Neutrophil-to-lymphocyte ratio as an independent factor for worse prognosis in radioiodine refractory thyroid cancer patients

Cited by 4 publications

References 43 publications

The role of neutrophil heterogeneity on T-cell immunity and prognosis in thyroid cancer patients

The role of neutrophil heterogeneity on T-cell immunity and prognosis in thyroid cancer patients

Neutrophil diversity is associated with T-cell immunity and clinical relevance in patients with thyroid cancer

Neutrophil-To-Lymphocyte Ratio as a Prognostic Indicator in Thyroid Cancer

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