Neutrophil to lymphocyte ratio as a measure of systemic inflammation in psoriasis

Şen, Bilge Bülbül; Rifaioğlu, Emine Nur; Ekiz, Özlem; İnan, Mehmet Uğur; Şen, Tuğba; Şen, Nihat

doi:10.3109/15569527.2013.834498

Cited by 131 publications

(115 citation statements)

References 24 publications

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“…Imtiaz et al (25) showed that NLR was significantly higher in subjects with DM and hypertension compared to the normal population. It has been reported that NLR can be affected in subjects with systemic diseases other than DM or hypertension, like pulmonary hypertension or obstructive sleep apnea syndrome and psoriasis (26)(27)(28). One drawback of our study is that we could not evaluate the existence of other systemic diseases as our study was retrospective.…”

Section: Discussionmentioning

confidence: 82%

Neutrophil-to-Lymphocyte Ratio as a Marker in Patients with Non-arteritic Anterior Ischemic Optic Neuropathy

Polat¹,

Yavaş²,

İnan³

et al. 2015

Balkan Med J

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Background: Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common acute optic neuropathy in patients over the age of 50 and is the second most common cause of permanent optic nerverelated visual loss in adults after glaucoma. Although the precise cause of NAION remains elusive, the etiology of NAION is believed to be multifactorial. Aims: To evaluate the utility of neutrophil-to-lymphocyte ratio (NLR) as a simple and readily available prognostic factor for clinical disease activity in patients with NAION. Study Design: Case-control study. Methods: Forty-five patients with the diagnosis of NAION and 50 age-and sex-matched controls with/ without any systemic or ocular diseases except cataract were retrospectively enrolled in the study. Demographic characteristics and laboratory findings including complete blood count of all patients and control subjects were obtained from the electronic medical record.The neutrophil and lymphocyte counts were recorded and the NLR was calculated. Results: White blood cell, neutrophil, NLR and platelet values of the NAION patients were significantly higher than those of the controls (p<0.001, p<0.001, p=0.004, p=0.037, respectively). Initial NLR values were negatively correlated with initial and the third month best corrected visual acuity levels in the study group. The optimum NLR cut-off point for NAION was 1.94. Conclusion: NLR could be considered as a new inflammatory marker for assessment of the severity of inflammation in NAION patients with its quick, cheap, easily measurable property with routine complete blood count analysis.

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Section: Discussionmentioning

confidence: 82%

Neutrophil-to-Lymphocyte Ratio as a Marker in Patients with Non-arteritic Anterior Ischemic Optic Neuropathy

Polat¹,

Yavaş²,

İnan³

et al. 2015

Balkan Med J

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“…Again, numerous studies suggested that NLR is an important criterion in making diagnostic and prognostic decisions in psoriasis, infective endocarditis, pneumonia, bacteremia and acute appendicitis. [13][14][15][16][17] In our study, we found that lymphocyte was higher in the patient group than the control group, and as a result, NLR was significant. This result supports the cause of chronic inflammation which plays an etiologic role in children with LAP.…”

Section: Discussionmentioning

confidence: 83%

The investigation of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in children with pathological cervical lymphadenopathy

Sarıca¹,

Bilal²,

Orhan³

et al. 2017

ENT Updates

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Lymphadenopathies constitute most of the neck masses of the children. Lymph nodes are arranged along the lymphatic canal. They are rich in lymphocytes and antigenpresenting cells and surrounded by a fibrous capsule. Lymph node enlargement in local and systemic infectious cases is seen as lymphadenomegaly or lymphadenopathy Yöntem: Muayene s›ras›nda saptanan herhangi bir neden olmaks›z›n boyunda fliflme flikayetiyle 2014 ile 2017 y›llar› aras›nda KBB klini¤i-ne kabul edilen ve idiyopatik patolojik LAP tan›s› konulan toplam 100 çocuk retrospektif çal›flmaya dahil edildi. Kontrol grubu herhangi bir enfeksiyonu olmayan ve muayene ve laboratuvar tahlillerine göre sa¤-l›kl› oldu¤u düflünülen 100 çocuktan oluflmaktayd›. Hastalar ve kontrol grubu klinikteki hasta kay›tlar›na bak›larak yafl, cinsiyet, klinik öykü, hastal›k süreci ve muayene bulgular› aç›s›ndan tarand›. Bulgular:Hasta grubunda ortalama lökosit ve lenfosit say›lar› kontrol grubundan daha yüksek olup farkl›l›k istatistiksel olarak anlaml›yd› (s›ra-s›yla p=0.008 ve p=0.001). Hasta grubunda ortalama NLO ve TLO de¤erleri kontrol grubuna göre anlaml› derecede daha düflüktü (s›ras›yla p=0.009 ve p=0.020). Sonuç:Bilinmeyen etiyolojili patolojik servikal LAP nedeniyle takip edilen çocuklarda NLO ve TLO enflamasyonla iyi bir korelasyon gös-terebilir.Anahtar sözcükler: Nötrofil/lenfosit orant›s›, trombosit/lenfosit orant›s›, lenfadenopati. AbstractObjective: To reveal whether if neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) rates are useful or not in children followed-up due to pathological cervical lymphadenopathy (LAP) of unknown etiology who have a normal hematologic examination. Methods:A total of 100 children admitted to the otorhinolaryngology clinic between 2014 and 2017 with the complaint of swelling in the neck without any etiology revealed on examination and established with the diagnosis of idiopathic pathological LAP were retrospectively included in the study. The control group consisted of 100 children who did not have any infectious condition and could be considered healthy in terms of examination and laboratory findings. Patients' and the control group's age, gender, clinical history, disease course and examination findings were screened from the patients' records in the clinic. Results:Mean white blood cell and lymphocyte count parameters in the patient group were higher than the control group, and the difference was statistically significant (p=0.008 and p=0.001, respectively). In the patient group, mean NLR and PLR values were significantly lower than the control group (p=0.009 and p=0.020, respectively).Conclusion: NLR and PLR rates may be well correlated with inflammation in children followed-up due to pathologic cervical LAP with unknown etiology.

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“…Recently, NLR has been recognized as a simple and cost-effective peripheral biomarker that indicates the inflammatory status because it is believed to reflect the numerical balance between neutrophils and lymphocytes in the blood (9,10,15,16). CRP and ESR are elevated in the event of systemic inflammation, and combined use of ESR and CRP was considered to be more appropriate as inflammatory markers (17).…”

Section: Discussionmentioning

confidence: 99%

The Clinical Significance of the Neutrophil-to-Lymphocyte Ratio in Patients with Guillain-Barré Syndrome Independent of Infection

et al. 2016

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Neutrophil to lymphocyte ratio as a measure of systemic inflammation in psoriasis

Abstract: Our data show that the N/L ratio to be a simple, inexpensive and easily assessable marker of systemic inflammation in patients with psoriasis.

Cited by 131 publications

References 24 publications

Neutrophil-to-Lymphocyte Ratio as a Marker in Patients with Non-arteritic Anterior Ischemic Optic Neuropathy

Neutrophil-to-Lymphocyte Ratio as a Marker in Patients with Non-arteritic Anterior Ischemic Optic Neuropathy

The investigation of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in children with pathological cervical lymphadenopathy

The Clinical Significance of the Neutrophil-to-Lymphocyte Ratio in Patients with Guillain-Barré Syndrome Independent of Infection

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