Neutrophil to lymphocyte ratio associated with prognosis of lung cancer

Abstract

Elevated NLR is a potential biomarker to identify lung cancer patients with poor prognosis and should be validated in a future clinical trial.

The Preoperative Composite Physiologic Index May Predict Mortality in Lung Cancer Patients with Combined Pulmonary Fibrosis and Emphysema

“…The diagnosis of CPFE was made based on imaging criteria as described below. The PNI, NLR, and PLR, which had previously been reported to be prognostic determinants of lung cancer [16,17,18,19,20], were calculated based on the laboratory data. The CPI, which represents a combination of pulmonary ventilation and diffusing capacity, was calculated based on the pulmonary function data.…”

“…The preoperative prognostic nutritional index (PNI), which is calculated based on serum albumin levels and the total lymphocyte count in peripheral blood, is a predictor of recurrence [16] or of a poor prognosis [17,18] in NSCLC patients who have undergone surgery. An elevated neutrophil-to-lymphocyte ratio (NLR) [19] and an elevated platelet-to-lymphocyte ratio (PLR) [20] are associated with a poor prognosis in lung cancer patients.…”

Incidence, Risk Factors, and Effect on Survival of Immune-related Adverse Events in Patients With Non–Small-cell Lung Cancer

“…Cancer-associated inflammation has long been recognized as having a profound effect on survival, 13 and markers of systemic inflammation such as the neutrophil/lymphocyte ratio (NLR) have been found to be prognostic in large meta-analyses of all cancers 14 and NSCLC. 15,16 However, the ability of baseline markers of systemic inflammation, including the NLR, platelet/ lymphocyte ratio (PLR), 17,18 and advanced lung cancer inflammation index (ALI), 19,20 to predict irAEs has not been assessed.…”

The interplay between neutrophils and microbiota in cancer

“…Despite their short time in circulation, neutrophils are swift first responders to inflammation and can bring about a potent, complex milieu of either proapoptotic, prosurvival, mutagenic, or wound healing signals, making their role in cancer pathogenesis a complex one . High blood neutrophil‐to‐lymphocyte ratios are associated with larger tumor size, less differentiated tumors, increased tumor vascularization, poor overall survival, and recurrence‐free survival rates in numerous cancers . However, other studies link neutrophil markers to better survival rates .…”

“…7,8 High blood neutrophil-to-lymphocyte ratios are associated with larger tumor size, less differentiated tumors, increased tumor vascularization, poor overall survival, and recurrencefree survival rates in numerous cancers. [9][10][11] However, other studies link neutrophil markers to better survival rates. [12][13][14][15][16][17] Rather than their sheer number, the types of tumor-infiltrating neutrophils and their state of differentiation/activation, as we will describe here, may play a significant role in cancer.…”