Neutrophil‐to‐lymphocyte ratio associated with mortality in early hepatocellular carcinoma patients after radiofrequency ablation

Chen, Tsung-Ming; Lin, Chung-Saint; Huang, Pi‐Teh; Wen, Chen-Fan

doi:10.1111/j.1440-1746.2011.06910.x

Cited by 125 publications

(114 citation statements)

References 35 publications

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“…Of these, NLR is one of the most simple and effective markers of inflammation and is linked with poor prognosis in various cancer types (26)(27)(28). Several studies demonstrated that an elevated NLR was associated with worse survival in patients with HCC who underwent radiofrequency ablation, TACE, resection and liver transplantation (29)(30)(31)(32). However, the exact association between a high NLR and poor prognosis has not been fully elucidated.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and prognostic factors for advanced hepatocellular carcinoma with extrahepatic metastasis

Aino

Sumie

Nishizaki

et al. 2014

Molecular and Clinical Oncology

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Abstract. Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. The aim of this study was to evaluate whether there are differences in the clinical characteristics and survival between patients with advanced HCC with extrahepatic metastasis who received and those who did not receive previous treatment. Between April, 1998 and April, 2012, a total of 419 HCC patients with extrahepatic metastasis (81 previously untreated and 338 previously treated) were enrolled in this study. The differences in the clinical characteristics, including metastatic sites, were compared between the two groups. In addition, the prognostic predictors among all the patients and among the 81 previously untreated patients were analyzed. The distribution of the major metastatic sites was similar in the two groups; the most frequent site of extrahepatic metastasis was the lungs, followed by the bones, lymph nodes and adrenal glands. The median survival time (MST) among the 419 patients was 6.8 months. The 1-, 2-, 3-and 5-year survival rates were 31.6, 15.3, 9.5 and 2.3%, respectively. No significant differences in survival were observed between patients who received and those who did not receive previous treatment. The multivariate analysis revealed that the Child-Pugh classification, white blood cell count, neutrophil-lymphocyte ratio (NLR) and primary tumor stage were independent predictors of survival for all the patients and for the 81 previously untreated patients. Differences in the clinical characteristics of patients with advanced HCC with extrahepatic metastasis were identified between patients who received and those who did not receive previous treatment. Furthermore, intrahepatic tumor status, Child-Pugh classification, white blood cell count and NLR were demonstrated to be independent predictors of survival in HCC patients with extrahepatic metastasis. IntroductionHepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Recent advances in imaging technology and implementation of surveillance programs for high-risk patients have led to increased detection of early-stage HCC, making curative therapies possible in some patients (1,2). However, the long-term survival of HCC patients remains unsatisfactory, due to the high frequency of intra-and extrahepatic recurrence (3,4). In particular, the development of advanced HCC with extrahepatic metastasis hinders the use of curative therapies, such as surgical resection or radiofrequency ablation, therefore contributing to poor survival. Prior to the approval of sorafenib, several systemic chemotherapeutic regimens had been evaluated for patients with advanced HCC, although no effective therapeutic protocols were identified (5,6). Two randomized placebo-controlled trials demonstrated a survival benefit associated with sorafenib for patients with advanced HCC, including those with extrahepatic metastasis (7,8). As a result, sorafenib is currently considered to be the standard treatment for advanced HCC in the United States, Europe, Japan ...

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Section: Discussionmentioning

confidence: 99%

Clinical characteristics and prognostic factors for advanced hepatocellular carcinoma with extrahepatic metastasis

Aino

Sumie

Nishizaki

et al. 2014

Molecular and Clinical Oncology

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“…In previous studies, increased NLR was demonstrated in cardiovascular and cerebrovascular diseases such as hypertension, unstable angina pectoris, myocardial infarction, transient ischemic attacks and stroke [9][10][11][12][13]. Moreover NLR has been found as a valuable index for predicting clinical outcomes in oncology [14][15][16][17] and inflammatory diseases such as Alzheimer, ulcerative colitis and appendicitis [18][19][20] . To our knowledge, this is the first study investigating the relationship between NLR levels and RAS.In this study we found that NLR levels in patients with RAS were higher than the control group.…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Neutrophil to Lymphocyte Ratio and Recurrent Aphthous Stomatitis

Özler¹

2016

Ann Clin Anal Med

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ÖzetAmaç: Bu çalışamnın amacı rekürren aftöz stomatitli hastalarda nötrofil lenfosit oranının artıp artmadığını araştırmaktır.Ayrıca,nötrofil lenfosit oranı ile oral ülser aktivitesi arasında korelasyon olup olamadığı araştırılmıştır. Gereç Anahtar KelimelerRekürren Aftöz Stomatit; İnflamasyon; Nötrofil Lenfosit Oranı Abstract Aim: The aim of this study is to investigate whether neutrophil to lymphocyte ratio(NLR) levels are elevated in patients with recurrent aphthous stomatitis(RAS). Moreover, we aimed to find out whether there is a correlation between NLR levels and oral ulcer activity. Material and Method: The study group consisted of 35 subjects with RAS and 35 age and sex matched control subjects. The examination of the subjects included a detailed history, general physical examination and assessment of laboratory blood parameters. Results: The mean NLR values were 2.05 ± 0.63 in RAS group and 1.34 ± 0.48 in the control group. The mean NLR values in the patients with RAS were significantly higher than the control group (p =0.0001).Moreover, there was positive correlation between NLR values and oral ulcer activity (r =0.586, p=0.0001). Discussion: There is no previous study that investigated the relationship between NLR and RAS in the literature. NLR should be taken into account as quick, cheap, easily measurable, new inflammatory marker, instead of other acute-phase proteins.

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“…PTA: pure tone average. cardiology (acute coronary syndromes, heart failure, and coronary revascularization procedures); end-stage renal disease; and inflammatory diseases such as Alzheimer, ulcerative colitis, and appendicitis [21,22]. A higher NLR indicates a higher level of inflammation [23].…”

Section: Discussionmentioning

confidence: 99%

The Significance of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Markers for Prognosis in Idiopathic Sudden Sensorineural Hearing Loss

Yi¹,

Oh²,

Choi³

et al. 2018

Korean J Otorhinolaryngol-Head Neck Surg

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Background. We aim to provide useful evidence about the association of neutrophil-to-lymphocyte ratio (NLR) and platelet-tolymphocyte ratio (PLR) with idiopathic sudden sensorineural hearing loss (ISSNHL) and its possibility of emerging as a cheap, reliable, and independent prognostic marker of ISSNHL. Methods. 348 patients diagnosed with ISSNHL were included in our retrospective data analysis. Blood samples and the hearing assessments of the patients were carried out. Then, the patients were divided into 2 groups as "recovered" and "unrecovered" according to their response to the treatment. Results. Both mean NLR and PLR values of the ISSNHL patients were significantly higher than the control group (both < 0.001). The NLR value was 5.98±4.22 in the unrecovered group and 3.50±3.38 in the recovered group ( < 0.001). After adjustment in a binary logistic regression model, only NLR value was associated with the recovery of ISSNHL ( = 0.001). Discussion. We demonstrated for the first time that NLR and PLR values were significantly high in ISSNHL patients. Also the NLR level might be taken into account as a novel potential marker to predict the patients' prognosis in terms of recovery.

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Neutrophil‐to‐lymphocyte ratio associated with mortality in early hepatocellular carcinoma patients after radiofrequency ablation

Abstract: High baseline NLR was associated with worse OS for patients with early HCC; post-RFA NLR predicted not only OS, but also tumor recurrence.

Cited by 125 publications

References 35 publications

Clinical characteristics and prognostic factors for advanced hepatocellular carcinoma with extrahepatic metastasis

Clinical characteristics and prognostic factors for advanced hepatocellular carcinoma with extrahepatic metastasis

The Relationship Between Neutrophil to Lymphocyte Ratio and Recurrent Aphthous Stomatitis

The Significance of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Markers for Prognosis in Idiopathic Sudden Sensorineural Hearing Loss

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