Neutrophil-to-lymphocyte ratio, Factor VIII and Antithrombin III: Inflammatory-clotting biomarkers in glioma

Koudriavtseva, Tatiana; Villani, Veronica; Lorenzano, Svetlana; Giannarelli, Diana; Domenico, Enea Gino Di; Stefanile, Annunziata; Maschio, Marta; D’Agosto, Giovanna; Pimpinelli, Fulvia; Tanzilli, Antonio; Galiè, Edvina; Pace, Andrea

doi:10.17179/excli2021-3831

Cited by 4 publications

(2 citation statements)

References 63 publications

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“…In this context, selectins are considered the initial mediators for the recruitment of leukocytes to the vessel wall (Läubli and Borsig, 2010[ 42 ]), while experimental studies revealed that VWF networks act as linker for adhesion of monocytes and neutrophils to the vascular endothelium supporting extravasation of leukocytes and therefore inflammation (Läubli and Borsig, 2010[ 42 ]; Pendu et al, 2006[ 56 ]; Bauer et al, 2022[ 5 ]). Of those, neutrophils seem to play a critical role for malignancy, coagulation, and inflammation (Bauer et al, 2022[ 5 ]; Koudriavtseva et al, 2021[ 38 ]). Interestingly, it has also been shown that NETs - whose thrombogenic role has already been described in detail in the context of COVID-19 - are able to directly trap circulating tumor cells and support extravasation and thus metastasis (Wu et al, 2019[ 77 ]).…”

Section: Coagulation In Covid-19 Patients With Cancermentioning

confidence: 99%

Elevated risk of thrombotic manifestations of SARS-CoV-2 infection in cancer patients: A literature review

Stefanile

Cellerino

Koudriavtseva

2022

EXCLI Journal; 21:Doc906; ISSN 1611-2156

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Coronavirus disease 2019 (COVID-19) results in higher risks of hospitalization or death in older patients and those with multiple comorbidities, including malignancies. Patients with cancer have greater risks of COVID-19 onset and worse prognosis. This excess is mainly explained by thrombotic complications. Indeed, an imbalance in the equilibrium between clot formation and bleeding, increased activation of coagulation, and endothelial dysfunction characterize both COVID-19 patients and those with cancer. With this review, we provide a summary of the pathological mechanisms of coagulation and thrombotic manifestations in these patients and discuss the possible therapeutic implications of these phenomena.

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Section: Coagulation In Covid-19 Patients With Cancermentioning

confidence: 99%

Elevated risk of thrombotic manifestations of SARS-CoV-2 infection in cancer patients: A literature review

Stefanile

Cellerino

Koudriavtseva

2022

EXCLI Journal; 21:Doc906; ISSN 1611-2156

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“…els may help in early detection of venous thromboembolism in patients with advanced pancreatic cancer[56].Koudriavtseva et al showed increased levels of ANT III in patients with glioma[57].Plasma protease C1 inhibitor is a protein known to undergo Oglycosylation, and GO analysis showed that plasma protease C1 inhibitor is primarily involved in immune response, complement…”

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confidence: 99%

Exploration of quantitative site‐specific serum O‐glycoproteomics with isobaric labeling for the discovery of putative O‐glycoprotein biomarkers

Zhang

Tian

2022

Proteomics Clinical Apps

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Purpose Exploration study of site‐specific isobaric‐TMT‐labeling quantitative serum O‐glycoproteomics for the discovery of putative O‐glycoprotein cancer biomarkers. Experimental design Sera of 10 breast cancer patients was used as the exploration cohort. More abundant N‐glycosylation was first removed with PNGase F. After tryptic digestion of de‐N‐glycosylated serum proteome, the TMT‐labeled O‐glycopeptides mixture was prepared and analyzed with RPLC‐MS/MS. Site‐specific qualitative and quantitative database search of O‐glycopeptides was carried out with pGlyco 3.0. The same raw datasets were also searched with intact N‐glycopeptide search engine GPSeeker to exclude possible interference of N‐glycosylation. The final IDs were checked manually with GlcNAc‐containing glycosite‐determining fragment ions for confirmation. Results With the control of spectrum‐level FDR ≤ 1% and manual validation, 299 O‐glycopeptides corresponding to 83 O‐glycosites and 66 O‐glycoproteins were identified, and 13 O‐glycopeptides were found differentially expressed. Most interestingly, differential O‐glycosylation was observed for IgG1 and IgG3, which is an interesting putative biomarker panel. Conclusion and clinical relevance Isobaric‐labeling site‐specific quantitative O‐glycoproteomics is currently a state‐of‐the‐art instrumental platform for discovery of putative seral cancer biomarkers. Differential seral O‐glycosylation was observed in the IgG1 and IgG3.

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Expression and Clinical Significance of Lymphocyte Subpopulations and Peripheral Inflammatory Markers in Glioma

Zhou,

Xu,

Geng

et al. 2024

JIR

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Purpose Patients with glioma often fail to achieve satisfactory outcomes despite receiving surgery, radiotherapy, and chemotherapy. Photodynamic therapy (PDT) shows promise in addressing the limitations of traditional treatments. However, the immunological effects of PDT in glioma patients remain underexplored. This study aims to fill this gap by analyzing lymphocyte subpopulations and inflammatory markers in glioma patients undergoing PDT-assisted surgery. Patients and Methods To enhance our comprehension of the immunobiology of glioma within a clinical framework, we conducted a retrospective analysis of glioma patients from September 2019 to December 2023. Peripheral blood lymphocyte subpopulations (CD3+, CD19+, CD4+, CD8+, CD4+/CD8+) and hematological inflammatory factors were compared among 18 patients who underwent surgery with PDT, 10 patients treated with surgery alone, and healthy controls. Additionally, lymphocyte subpopulations from 48 healthy individuals and hematology inflammatory factors from 38 healthy controls were regarded as controls. Results PDT-assisted surgery resulted in significant alterations in lymphocyte subpopulations and inflammatory markers before and after treatment, particularly in CD4+ and CD8+ T cells. PDT-treated patients demonstrated a superior therapeutic response compared to surgery alone (P=0.035). Notably, primary glioma patients had more prolonged overall survival than recurrent glioma patients (P=0.039). Conclusion PDT-assisted surgery significantly affects lymphocyte subpopulations and inflammatory markers, enhancing immune response in glioma patients. These findings support the use of PDT as an effective adjuvant therapy. Monitoring lymphocyte subpopulations and inflammatory markers may be valuable for glioma prognosis and treatment optimization.

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Neutrophil-to-lymphocyte ratio, Factor VIII and Antithrombin III: Inflammatory-clotting biomarkers in glioma

Cited by 4 publications

References 63 publications

Elevated risk of thrombotic manifestations of SARS-CoV-2 infection in cancer patients: A literature review

Elevated risk of thrombotic manifestations of SARS-CoV-2 infection in cancer patients: A literature review

Exploration of quantitative site‐specific serum O‐glycoproteomics with isobaric labeling for the discovery of putative O‐glycoprotein biomarkers

Expression and Clinical Significance of Lymphocyte Subpopulations and Peripheral Inflammatory Markers in Glioma

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