Neutrophil-to-lymphocyte ratio, factor VIII and antithrombin III: Inflammatory-clotting biomarkers in glioma

Koudriavtseva, Tatiana; Villani, Veronica; Lorenzano, Svetlana; Stefanile, Annunziata; Maschio, Marta; Galiè, Edvina; Tanzilli, Antonio; Pace, Andrea

doi:10.1016/j.jns.2021.117730

Cited by 1 publication

(3 citation statements)

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“…The prognostic significance of the ratio of the main cell populations of peripheral blood in MG patients has been extensively studied in recent years [13][14][15][16]. Patients included in our study showed significant signs of systemic inflammation such as increased counts of PBL and Neu, NLR, and SII.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, the integral quantitative indicators such as NLR and SII, which increased in MG patients, may be the subject of future attention, because other researchers also denoted an increase in NLR and SII in patients with gliomas, as well as the probable prognostic significance of the NLR ratio [15,16].…”

Section: Discussionmentioning

confidence: 99%

“…Separate studies have already evaluated the prognostic significance of the ratios of the main peripheral blood cell populations in MG patients: neutrophil (Neu) to lymphocyte (Ly) ratio (NLR), platelet (Pt) to Ly ratio (PLR), and monocyte (Mo) to Ly ratio (MLR) [13][14][15][16]. Considerable attention is paid to Pt in peripheral blood [17,18].…”

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confidence: 99%

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Systemic Inflammatory Indices in Patients With Malignant Gliomas and Effects of Platelet Secretome in Vitro

Rozumenko,

Liubich,

Pedachenko

et al. 2024

Exp. oncol.

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Background. To date, no significant clinical progress has been achieved in the treatment of brain malignant gliomas (MG), and the active search for non-invasive circulating biomarkers continues. The prognostic significance of the ratio of the main peripheral blood cell populations of patients with MG is evaluated. Considerable attention is paid to the secretome of platelets (Pt) of peripheral blood. Aim. To evaluate the indicators of the peripheral blood cell population ratios in patients with brain MG and to study the influence of the secretome of Pt (SPt) of the peripheral blood of patients with brain MG in cell cultures in vitro. Materials and Methods. We studied samples of peripheral blood from patients with glioma CNS WHO grade G2 (n = 5), G3 (n = 12), and G4 (n = 20). The peripheral blood cell counts were analyzed in the preoperative period on an automatic hematology analyzer. The in vitro study of SPt was performed on the U251 human glioblastoma cell line cultured with SPt from MG patients or SPt pre-incubated with anti-TGF-β1 antibody. Cell cultures were observed for 72 h, and mitotic index (MI) was calculated. Results. In MG patients, the count of peripheral blood leukocytes and neutrophils increased (p < 0.05). The neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) increased by 2—3 times compared to control. Nevertheless, correlation analysis did not reveal significant relationships between quantitative indicators of peripheral blood cells and the tumor malignancy degree in MG patients. The MI in U251 cells increased under the influence of SPt from patients with MG (p < 0.021), correlated with the tumor degree of malignancy (r = 0.246, p = 0.014). Pre-incubation of SPt with anti-TGF-β1 antibody tends to neutralize this promitotic effect. Conclusion. In MG patients, the integral indicators of NLR and SII increased but no significant relationship with the degree of tumor malignancy was found. In U251 cells, promitotic effects of SPt of MG patients partially decreased by anti-TGF-β1 antibody.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%