Neutrophil to Lymphocyte Ratio in Acute Ischemic Stroke

Lashin, Menat-Allah Mohamed; Khalil, Salma; Alloush, Taha Kamel; Anis, Sherif; Fouad, Mohamed M.

doi:10.4236/nm.2020.112007

Cited by 2 publications

(5 citation statements)

References 14 publications

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“…Out of the 60 patients, 46 (76.6%) patients survived the hospital stay and were discharged within a week, while 14 (23.3%) patients died within the first week of admission to the hospital. The median baseline NIHSS score was 18 (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27) among patients who died. The mean age of the patients who survived was 61.06 years (SD=11.24) and that of those who died was 71 years (SD=10.64).…”

Section: Resultsmentioning

confidence: 99%

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An Elevated Neutrophil-to-Lymphocyte Ratio Predicts In-Hospital Mortality in Stroke Patients: A Prospective Cohort Study

Sharath¹,

Siddegowda²,

Lonimath³

et al. 2022

Cureus

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IntroductionCerebrovascular accidents or strokes are a major cause of mortality and morbidity in today's world. Poststroke disabilities like paralysis, dementia, etc., can affect the quality of life of patients as well as their families. A combined increase in neutrophils and a decrease in lymphocytes during inflammation in stroke manifests as an elevated neutrophil-to-lymphocyte ratio (NLR), thereby indicating the severity of neural damage.

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Section: Resultsmentioning

confidence: 99%

“…Conversely, a study conducted by Wang et al found no relation between the 30-day mortality rate and NLR calculated at the time of admission in patients with acute hemorrhagic stroke [ 19 ]. Lashin et al also did not find any significant association between NLR and the 30-day outcome in acute ischemic stroke patients [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

An Elevated Neutrophil-to-Lymphocyte Ratio Predicts In-Hospital Mortality in Stroke Patients: A Prospective Cohort Study

Sharath¹,

Siddegowda²,

Lonimath³

et al. 2022

Cureus

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“…Circulating platelets have two main roles in ischemic stroke: first the well-known role in thrombosis and secondly the promoter of inflammation activators (chemokines, cytokines) that mediate other cells in the peripheral blood [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…According to studies in recent literature (Du et al, 2020 [ 15 ]), platelet growth correlates with the risk of ischemic stroke, but without having any role in its predictability. Contrary to these studies, the authors claim that there is a moderate correlation in terms of PLR and stroke severity (NIHSS), in the study group the average value of PLR being 147.86, while in the control group 114.95.…”

Section: Discussionmentioning

confidence: 99%

“…As for platelets, information is not sufficiently clarified because the relativity between an increasing platelet count and clinical prognosis remains uncertain. Until now it is known only that platelets had a pivotal role in thrombogenesis and inflammation [14][15][16]. Therefore the role of inflammation in ischemic stroke is still insufficiently elucidated, which is why we need more studies that include different biomarkers physicians can rely on.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic markers for ischemic stroke – are they truly reliable?

Roman-FIlip

Catană

Mihăilă

2023

Medicine and Pharmacy Reports

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Background. Stroke is one of the leading causes of mortality and morbidity worldwide. Despite extensive research, to this date there is no panel of biomarkers for the prevention and prognosis of ischemic stroke and there is still much incomplete and insufficiently researched information. Aim. We conducted a prospective, observational study between January and June 2020. The main objective of this study was to clarify the role of inflammation markers, i.e. neutrophil/ lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), high-sensitivity C – reactive protein (hsCRP) in ischemic stroke and whether there is or not a correlation between these markers and carotid stenosis. Study design. In the study we included 150 subjects divided in two groups: study group – 100 subjects and control group – 50 subjects. Methods. Data collected during the research (at the time of patient admission): 1) biological sample: 5 ml of peripheral blood were collected in a vial with clot activator and separating gel, from which the following laboratory tests were performed: hsCRP, neutrophils, lymphocytes, platelets. NLR and PLR were subsequently calculated as the ratio of neutrophils to lymphocytes, respectively platelets and lymphocytes), 2) paraclinical examinations: extracranial carotid Doppler ultrasound examination. Results. The results were impressive: high-sensitivity C reactive protein (hsCRP), neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) were strongly, respectively moderately correlated with the severity of stroke (the severity being established with the NIHS (National Institute of Health Stroke) score. None of the inflammation markers included in the present study was correlated with carotid stenosis. Conclusion. hsCRP, NLR and PLR may potentially be prognostic markers for ischemic stroke, being of major help in preventing its possible complications.

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Neutrophil to Lymphocyte Ratio in Acute Ischemic Stroke

Cited by 2 publications

References 14 publications

An Elevated Neutrophil-to-Lymphocyte Ratio Predicts In-Hospital Mortality in Stroke Patients: A Prospective Cohort Study

An Elevated Neutrophil-to-Lymphocyte Ratio Predicts In-Hospital Mortality in Stroke Patients: A Prospective Cohort Study

Prognostic markers for ischemic stroke – are they truly reliable?

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