Neutrophil-to-lymphocyte ratio in occlusive vascular diseases: the literature review of the past 10 years

Objectives:This study aimed to investigate the relationship between the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) and Bell's palsy in addition to the usability of these markers to predict prognosis. Methods: In this prospective study, the patient group included 24 patients that were diagnosed with Bell's palsy and 29 healthy volunteers that had similar characteristics to them regarding age and gender with patient group as the control group. The temporal gadolinium-enhanced magnetic resonance imaging (TGd-MRI) was performed to all patients. The complete blood count was also obtained from both the patient and the control groups, and these two groups were compared for NLR and PLR, mean platelet volume (MPV), platelet distribution width (PDW), and platelet count. The relationship between these markers and Bell's paralysis prognosis was also investigated. Results: The patient and control groups were similar in age and gender (p > 0.05). NLR was significantly higher in the patient group compared with the control group (p = 0.016). There was no correlation between the NLR value and the prognosis of Bell's Palsy. The PDW and white blood cell count (WBC) were significantly higher in the patient group than the control group (p = 0.023 and p = 0.012, respectively). A comparison of the recovered and unrecovered patients revealed that the PDW value was significantly higher and the platelet count was lower in the recovered patients than the unrecovered patients (p = 0.009 and p = 0.003 respectively). The MPV value was higher in the recovered patients, though not statistically significant (p = 0.063). Based on the cut-off values determined in the receiver operator characteristic (ROC) curve analysis, a comparison of the recovered and unrecovered patients reveals that the likelihood of not healing was significantly higher in those that had normal PDW values (p = 0.036). Conclusion: These results might support the theory of inflammation in patients with Bell's palsy.

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“…NLR is frequently used as a new inflammation marker according to recent studies [3][4][5]8]. NLR can be easily calculated with a CBC test.…”

Section: Discussionmentioning

confidence: 99%

The role of inflammation markers in predicting the prognosis of Bell's palsy

Ulusoy

Bozdemir

Kale

et al. 2019

The European Research Journal

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“…Recent studies have shown that systemic inflammatory markers are associated with BC prognosis, and most studies have focused on the prognostic role of the NLR [ 19 ], platelet–lymphocyte ratio (PLR) [ 20 ], and Glasgow prognostic score [ 21 ]. NLR has also been reported to be a supportive marker in the diagnosis of inflammatory and autoimmune diseases [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Preoperative Fibrinogen and Hematological Indexes in the Differential Diagnosis of Idiopathic Granulomatous Mastitis and Breast Cancer

et al. 2021

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Background and Aim: Studies on hematological parameters in the differential diagnosis of idiopathic granulomatous mastitis (IGM) and breast cancer (BC) are limited. This study investigated whether preoperative fibrinogen and hematological indexes can be used in the differential diagnosis of patients with IGM and early-onset BC. Methods: Fifty patients with BC, 55 patients with IGM, and 50 healthy volunteer women were included in the study. Results: There was a statistically significant difference between the IGM and the BC with respect to fibrinogen, fibrinogen/albumin (Fib/Alb) ratio, C-reactive protein (CRP), white blood cells (WBC), neutrophils, neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR), and monocyte values. When fibrinogen (p < 0.001), the Fib/Alb ratio (p < 0.001), CRP (p < 0.001), WBC (p < 0.001), neutrophil (p < 0.001), NLR (p < 0.001), monocyte (p = 0.008), and 2-hour sedimentation rate (p < 0.001) were compared between the groups, the highest levels were found in the IGM group. There was a negative relationship between CRP and albumin, and a positive relationship was observed between CRP and WBC, NLR, PLR, and 2-h sedimentation rate. CRP had the highest sensitivity (95%), whereas the Fib/Alb ratio (86%) had the highest specificity. Patients with recurrent IGM had increased fibrinogen, Fib/Alb, CRP, neutrophils, NLR, and 2-h erythrocyte sedimentation rate (ESR) and decreased lymphocyte levels compared to non-recurrent patients. Conclusions: Preoperative CRP, albumin, fibrinogen, Fib/Alb, WBC, neutrophil, NLR, monocyte, and 2-h ESR have considerable potential to be early and sensitive biomarkers of IGM caused by inflammation compared to BC. These parameters also have a significant effect on the recurrence of the disease, suggesting their potential as a practical guide for the differential diagnosis of BC from IGM.

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“…In recent years, NLR was used as a supportive marker for the diagnosis of inflammatory and autoimmune diseases [18,19]. There are a limited number of studies that explore the association between NLR and IGM.…”

Section: Discussionmentioning

confidence: 99%

White Blood Count Can Be a Practical Guide for the Differential Diagnosis of Breast Abscess and Idiopathic Granulomatous Mastitis

Akalın¹,

Altaş²,

Çelik³

2020

Cureus

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Introduction and aim Idiopathic granulomatous mastitis (IGM) is an inflammatory disease of the breast and has the same symptoms and radiologic imaging as breast abscess (BA). The aim of this study is to evaluate the use of inflammatory markers as white blood count (WBC), C-reactive protein (CRP), and neutrophil to lymphocyte ratio (NLR) as a potentially useful tool for the differential diagnosis of BA and IGM. Methods In this retrospective study, we analyzed 31 patients with IGM and 47 patients with BA between January 2013 and April 2020. Age, symptoms, symptomatic breast side, microbiological culture, complete blood count, and C-reactive protein (CRP) values of patients were analyzed. Receiver operating characteristic (ROC) curve analysis was used to define the optimal cutoff for WBC, CRP, and NLR. Results WBC was significantly higher in the BA group compared to the IGM group (11.45 vs. 9.78; p=0.042), but no difference was found for CRP and NLR between these groups (p=0.146, p=0.081, respectively). In ROC analysis results in BA group, cutoff values, the best sensitivity and specificity for WBC, CRP, and NLR were 8.46 × 10 3 /μL (81%-70%), 1.5 mg/dl (77-76%), and 2.93 (70-82%), respectively. For IGM group, cutoff values, the best sensitivity and specificity for WBC, CRP and NLR were 8.49 × 10 3 /μL (74-70%), 1.5 mg/dl (61-76%) and 2.29 (64-72%), respectively. Conclusion This study showed that CRP and NLR cannot be used as a useful tool for differential diagnosis of IGM; furthermore, WBC is a parameter that can act as a practical guide for the differential diagnosis of BA and IGM.

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Neutrophil-to-lymphocyte ratio in occlusive vascular diseases: the literature review of the past 10 years

Abstract: Elevated neutrophil-to-lymphocyte ratio at admission, could be used as a diagnostic and/or prognostic parameter in occlusive vascular diseases.

Cited by 15 publications

References 49 publications

The role of inflammation markers in predicting the prognosis of Bell's palsy

The role of inflammation markers in predicting the prognosis of Bell's palsy

Preoperative Fibrinogen and Hematological Indexes in the Differential Diagnosis of Idiopathic Granulomatous Mastitis and Breast Cancer

White Blood Count Can Be a Practical Guide for the Differential Diagnosis of Breast Abscess and Idiopathic Granulomatous Mastitis

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