Neutrophil-to-lymphocyte ratio in ocular diseases: a systematic review

Kurtul, Bengi Ece; Özer, Pınar Altiaylik

doi:10.18240/ijo.2019.12.18

Cited by 27 publications

(27 citation statements)

References 74 publications

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“…13 The neutrophil-to-lymphocyte ratio (NLR) is an accessible, reproducible and widely used biomarker for evaluating the prognosis of many health-related problems such as cardiovascular diseases, various types of cancer, ocular diseases and infectious diseases, among others. [14][15][16][17][18][19][20] The biological basis of this biomarker is related to the response of the innate immune system against systemic inflammation, injury and stress. This is characterised by lymphocytopaenia and neutrophilia.…”

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confidence: 99%

Prognostic value of neutrophil‐to‐lymphocyte ratio in COVID‐19 patients: A systematic review and meta‐analysis

et al. 2021

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Coronavirus disease 2019 (COVID-19) is an acute respiratory infection caused by SARS-CoV-2. [1][2][3] On 30 January 2020, the World Health Organization (WHO) declared the epidemic as a public health emergency of international interest. 4 After more than 20 000 cases and 1000 deaths in the European Region, the WHO classified the disease as a pandemic. 5 To date (14 May 2021), more than 162 million cases and 3.37 million deaths have already been reported across the world. 6 According to recent studies, the basic reproduction number (R0) is 3.38, suggesting high transmissibility. 7 Besides the significant human losses, the quarantine and social distancing have had a great impact on the global economy. 8 However, despite the implementation of these strategies, the incidence of cases has been increasing in some countries, and nowadays, some nations are experiencing a second wave.Sociodemographic and clinical factors, such as older age, male sex, hypertension and diabetes mellitus, increase the mortality rate

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confidence: 99%

Prognostic value of neutrophil‐to‐lymphocyte ratio in COVID‐19 patients: A systematic review and meta‐analysis

et al. 2021

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“…During this process, amounts of circulating mononuclear cell subpopulations may be altered by secreted cytokines and mediators, and cell to cell interactions and may give information about the disease activity or prognosis [4,14,15]. Blood count-derived immunoinflammatory biomarkers including NLR, PLR, MLR, and SII are inexpensive and easily accessible predictors to evaluate systemic inflammation, and they have been identified to be associated with the prognosis and the activity of many cardiovascular, oncologic and autoimmune diseases [5,6,11,16]. NLR is the most investigated inflammatory parameter in ocular diseases, and higher NLR level was found to be associated with the presence of diabetic retinopathy, age-related macular degeneration, acute optic neuritis, retinal vein occlusion, progressive keratoconus, uveitis, dry eye, pseudoexfoliation and primary open-angle glaucoma [6].…”

Section: Discussionmentioning

confidence: 99%

“…Blood count-derived immunoinflammatory biomarkers including NLR, PLR, MLR, and SII are inexpensive and easily accessible predictors to evaluate systemic inflammation, and they have been identified to be associated with the prognosis and the activity of many cardiovascular, oncologic and autoimmune diseases [5,6,11,16]. NLR is the most investigated inflammatory parameter in ocular diseases, and higher NLR level was found to be associated with the presence of diabetic retinopathy, age-related macular degeneration, acute optic neuritis, retinal vein occlusion, progressive keratoconus, uveitis, dry eye, pseudoexfoliation and primary open-angle glaucoma [6]. In literature, only one study evaluating the relationship be- None of the patients in the study received radiotherapy or any other immunosuppressant therapy except systemic steroid treatment; Mann-Whitney U-test was used for the statistical analysis and the data is shown as mean ± standard deviation (minimum-maximum).…”

Section: Discussionmentioning

confidence: 99%

“…Recently, some novel inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), have been used to assess the severity of inflammation in some autoimmune diseases [ 5 ]. The diagnostic and prognostic values of NLR have been investigated in some ocular diseases such as diabetic retinopathy, age-related macular degeneration, central serous chorioretinopathy, retinal vein occlusion, retinopathy of prematurity, pseudoexfoliation syndrome, keratoconus, optic neuropathy, dry eye disease, and uveitis [ 6 ].…”

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Blood Count-derived Immunoinflammatory Markers in Thyroidassociated Ophthalmopathy

Yeter

Koçak

Arslan³

et al. 2021

Korean J Ophthalmol

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Purpose To investigate the diagnostic and prognostic significance of the blood-count derived systemic immunoinflammatory parameters in patients with thyroid-associated ophthalmopathy (TAO). Methods In this retrospective case-control study, the blood-count parameters and neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio, and systemic immune-inflammatory index (SII), thyroid peroxidase antibody, and anti-thyroglobulin antibody were evaluated in 46 patients with TAO and 46 matched controls. The associations of the immunoinflammatory parameters with clinical outcomes were analyzed among TAO patients. Results Significant differences were found in NLR, PLR, SII, and lymphocyte count between the controls and the TAO group ( p < 0.05 for all). In logistic regression analysis, these inflammatory parameters did not have any prognostic effect on the clinical outcomes of the TAO ( p > 0.05 for all). The patients, who needed systemic treatment due to any ocular involvement of TAO during the follow-up period, had significantly lower platelet count ( p = 0.001) and PLR ( p = 0.02) at the time of initial diagnosis when compared to the no treatment-needed group of the TAO patients. The initial platelet count was significantly associated with the subsequent steroid need due to TAO during the follow-up period (β = −0.02, p = 0.03). Conclusions NLR, PLR, and SII may serve as potential inflammatory markers in the identification of the TAO, although they have no evident prognostic significance in TAO. However, the relatively lower platelet count at initial diagnosis may be associated with the need for systemic therapy during the follow-up in patients with TAO.

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“…indicators of systemic inflammatory conditions obtained from peripheral venous sampling, including the neutrophil / lymphocyte ratio (NLR), platelet / lymphocyte ratio (PLR), lymphocyte / monocyte ratio (LMR), serum lipid levels, and the systemic immune inflammation index (SII), have been proposed as prognostic indicators in several inflammatory disorders and malignancies [1][2][3][4][5][6][7][8][9] .…”

Section: Hematologicalmentioning

confidence: 99%

Comparison of hematological inflammatory parameters in patients with exfoliative glaucoma and exfoliative syndrome

Demirtaş¹,

Karahan²

2021

Dicle Tıp Dergisi

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Objective: To evaluate the neutrophil / lymphocyte ratio (NLR), platelet / lymphocyte ratio (PLR), and systemic immune inflammation index (SII) in exfoliative glaucoma (XFG) patients with the aim of comparing the findings with those of healthy controls and exfoliative syndrome (XFS) patients. Methods:In this retrospective cross-sectional study included 134 participants, 22 XFG patients, 41 XFS patients and 71 healthy individuals were examined. Peripheral venous sample values including neutrophil, lymphocyte and platelet levels were recorded from the hospital database.Results: Among evaluated hematological parameters, although the NLR values of the subjects with XFG were greater than those of the subjects with XFS, when the relationship between the NLR, PLR and SII parameters of the XFG and XFS groups, adjusted for age and gender, was examined by logistic regression analysis, no significant difference was found between the groups. Multiple linear regressions of the association between the NLR, PLR and SII parameters and the ocular parameters of the XFG and XFS groups revealed no significant relationship between the blood parameters and ocular measurements. Neutrophil / lymphocyte ratio was found to be the most acceptable discriminant parameter when comparing XFG group with the XFS and control groups (AUC [area under curve]=0.678, AUC=0.663, respectively). Platelet / lymphocyte ratio was found to be the best discriminant parameter between the XFS and control groups (AUC=0.605). Conclusion:No significant difference was found between XFG and XFS groups in terms of NLR, PLR and SII parameters. Considering the fact that NLR has the best AUC when comparing XFG and XFS groups, it may be the most acceptable discriminant parameter between XFG and XFS.

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Neutrophil-to-lymphocyte ratio in ocular diseases: a systematic review

Cited by 27 publications

References 74 publications

Prognostic value of neutrophil‐to‐lymphocyte ratio in COVID‐19 patients: A systematic review and meta‐analysis

Prognostic value of neutrophil‐to‐lymphocyte ratio in COVID‐19 patients: A systematic review and meta‐analysis

Blood Count-derived Immunoinflammatory Markers in Thyroidassociated Ophthalmopathy

Comparison of hematological inflammatory parameters in patients with exfoliative glaucoma and exfoliative syndrome

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