Neutrophil to lymphocyte ratio is not related to carotid atherosclerosis progression and cardiovascular events in the primary prevention of cardiovascular disease: Results from the IMPROVE study

Abstract

Inflammation is a component of the pathogenesis of atherosclerosis and is associated with an increased risk of atherosclerotic cardiovascular disease (ASCVD). The neutrophil to lymphocyte ratio (NLR) is a possible

Neutrophil to Lymphocyte Ratio: An Emerging Marker of the Relationships between the Immune System and Diseases

“…By contrast, recent data collected by Mannarino et al do not support the role of NLR as a predictor of the risk of atherosclerosis progression and atherosclerotic cardiovascular disease (ASCVD) events in subjects at moderate-to-high ASCVD risk, in primary prevention. However, the usefulness of NLR for patients at a different level of ASCVD risk, as recognized by the authors themselves, cannot be inferred from this study [ 54 ]. Elevated NLR on admission, for particular values > 2.97 (sensitivity of 92.6% and specificity of 52.5%, AUC = 0.714, p = 0.001) was an independent predictor of all-cause 3-month mortality for hospitalized hypertensive patients older than 80 years [ 55 ].…”

A Relação entre a Relação Ácido Úrico/Albumina e a Espessura Média-Intimal da Carótida em Pacientes com Hipertensão

“… 30 Mannarino et al reported that NLR was correlated with CIMT but not with CIMT progression over the years. 31 Like that study, Lee et al found NLR as an independent predictor of high CIMT. 32 PLR was also associated with CIMT in a recent study conducted by Kaya et al 33 Following those studies, our study found that CAR, NLR, and SII but not PLR were associated with high CIMT.…”

“… 30 Mannarino et al relataram que RNL foi correlacionada com EMIC, mas não com a progressão da EMIC ao longo dos anos. 31 Assim como esse estudo, Lee et al encontraram RNL como um preditor independente de EMIC alta. 32 RPL também foi associada com EMIC em um estudo recente conduzido por Kaya et al 33 Após esses estudos, nosso estudo descobriu que RCA, RNL e IIS, mas não RPL, estavam associados a EMIC alta.…”

Novel Insight Into Long-Term Risk of Major Adverse Cardiovascular and Cerebrovascular Events Following Lower Extremity Arteriosclerosis Obliterans

“…Inflammatory cytokines follow various stages of atherosclerosis, emphasizing the vital function of inflammation in the pathogenesis of atherosclerosis ( 20 , 21 ). Recently, the popularity of atherosclerotic inflammation theory has mainly focused on emerging indicators such as NLR and PLR ( 22 – 25 ). The NLR, a novel meaningful and easily obtained inflammatory biomarker, serves not only as an independent predictor of carotid plaque vulnerability but also as a key predictor of future CV events and all-cause mortality ( 26 , 27 ).…”