Neutrophil-to-lymphocyte ratio (NLR) and Platelets-to-lymphocyte (PLR) Ratio in Patients with Exacerbation of Bronchiectasis

Abstract

Neutrophil-to-lymphocyte ratio (NLR) and platelets-to-lymphocyte ratio(PLR) are novel inflammatory markers used in evaluation of systemic inflammation. The aim of this study was to evaluate the utility of NLR and PLR as inflammatory markers in patients with exacerbation of bronchiectasis. 100 patients with age between 23 and 88 years old with chest CT documentated bronchiectasis were included. Blood test were collected at admission in the hospital. There was a good correlation between classical markers such as CRP, ESR, white blood cells and NLR. PLR, however correlated only with ESR from the inflammatory markers and with the values og hemoglobin and hematocrit. We did not see higher values in patients with COPD and bronchiectasis when compared with patients with bronchiectasis alone, howevere patients with COPD GOLD stage 2 and bronchiectasis had higher values of NLR and PLR when compared with other stages. NLR, more than PLR can be safley used in evaluating inflammation in patients with exacerbation of bronchiectasis.

Neutrophil-to-lymphocyte ratio, platelets-to-lymphocyte ratio, and eosinophils correlation with high-resolution computer tomography severity score in COVID-19 patients

“…They have been widely investigated in several other conditions such as malignancies (included hematological malignancies), respiratory, gastrointestinal, cardiovascular (acute coronary syndrome, intracerebral hemorrhage) or s, systemic diseases. Higher values have been associated with more severe forms of illness with the worst prognosis [7][8][9].…”

“…There are some notable hematological changes such as leucopenia, lymphopenia, eosinopenia, elevated CRP, ESR. Some changes are specific for SARS-COV 2 infection, like elevated D-dimers, high ferritin, and high LDH levels [1][2][3][4][5][6][7][8][9][10]. COVID-19 is more contagious than seasonal flu, and specific populations (older people and those with comorbidities, especially cardiovascular comorbidities) have a higher risk of death from COVID-19.…”

Neutrophil-to-Lymphocyte Ratio and Systemic Immune-Inflammation Index—Biomarkers in Interstitial Lung Disease

“…The neutrophil-to-lymphocyte ratio (NLR) is a marker of subclinical inflammation, with a higher values in exacerbations, in many lung diseases such as cancer, COPD, asthma, bronchiectasis, obstructive sleep apnea severity, obesity, and many cardiac diseases (ischemic heart disease, myocardial infraction) [10][11][12]. Patients with a higher NLR value have a relatively low lymphocyte count and a high neutrophil count and indirectly evaluates inflammatory status as well as cell-mediated immunity [13].…”

Pathogenesis, Prophylaxis, and Treatment of Candida auris

“…Other diseases with a risk of fungal infectious complications include chronic obstructive pulmonary diseases, which can lead especially to exacerbations [ 6 , 7 , 39 ]. A worsening of three or more of the primary symptoms, cough sputum consistency and/or volume, for longer than 48 h is considered an exacerbation of bronchiectasis [ 40 ].…”

“…The diagnosis must be comprehensive and approach multiple directions, for example, other complementary tests, such as C reactive protein, which may be particularly important for tracking the course of the illness or the efficacy of treatment [ 50 ]. Due to their increased accessibility and lower cost as blood tests, the usefulness of the neutrophil-to-lymphocyte ratio and platelets-to-lymphocyte ratio as indicators of systemic inflammation has been examined in many studies conducted in recent years [ 40 ]. The significance of the platelets-to-lymphocyte ratio remains even if the neutrophil-to-lymphocyte ratio is a valid inflammatory marker in solid tumors, bronchiectasis, sleep apnea, and several other diseases [ 40 ].…”