Neutrophil-to-lymphocyte ratio (NLR) at boundaries of Progressive Supranuclear Palsy Syndrome (PSPS) and Corticobasal Syndrome (CBS)

Abstract

Aim of the study. To examine possible features of neuroinflammation in progressive supranuclear palsy -Richardson syndrome and corticobasal syndrome (CBS).Clinical rationale for the study. Neutrophil-to-lymphocyte ratio (NLR) is a parameter reflecting inflammation used in numerous branches of medicine. The search for pathogenesis of the diseases partly related to inflammatory processes confirms the need to obtain possible factors which could be relatively easily verified. NLR is a benchmark routinely evaluated in most hospitalised patients.Materials and methods. 23 patients with a clinical diagnosis of PSP-RS, 18 patients with CBS, and 32 healthy controls, were included in the study. Blood samples were assessed in the context of neutrophil and lymphocyte rates. Subsequently, the results were transformed into neutrophil-to-lymphocyte ratio (NLR). The NLRs from each group were statistically assessed using a Kruskal-Wallis test and post-hoc analysis.Results. Statistical analysis confirmed significant differences in NLR between PSP-RS and control group. No other significant differences were observed.Clinical implications. The possible use of NLR in the additional examination of atypical parkinsonisms. Conclusions.To the best of our knowledge, this is the first study comparing this aspect of neuroinflammation in PSP and CBS. It presents NLR as a promising non-specific parameter in neurodegenerative diseases.

Platelet-to-lymphocyte ratio and neutrophil-tolymphocyte ratio may reflect differences in PD and MSA-P neuroinflammation patterns

“…This study highlights the need to search for accessible tools facilitating the management and diagnosis of Parkinson's Disease and Multiple System Atrophy. To the best of our knowledge, this is the first paper evaluating PLR in the context of atypical parkinsonian syndrome; this parameter should be assessed in patients with atypical parkinsonian syndromes, as previously published studies have shown interesting results in the context of peripheral inflammation markers [56].…”

Blood Analytes as Biomarkers of Mechanisms Involved in Alzheimer’s Disease Progression

“…Moreover, it gives new insight that could support the research of an early diagnosis of AD. Future studies will investigate the relationship between non-specific blood analytes and the progression of other forms of dementia (e.g., Fronto-temporal dementia, Lewy body dementia) as well as other neurodegenerative diseases often associated with dementia symptoms (e.g., Parkinson disease [ 76 ]). Our methodological approach could highlight similarities and differences with AD, providing not only a tool for a more objective prognosis of such different forms of dementia but also a powerful approach for a differential diagnosis.…”

Impact of COVID-19 on Neuropsychiatric Disorders

“…Alzheimer’s disease (AD) and Parkinson’s disease (PD) are two neurodegenerative disorders reported to be caused by prolonged inflammation in patients infected by SARS-CoV-2 as a possible postinfectious manifestation. Inflammatory processes are also involved in other neurodegenerative disorders such as progressive supranuclear palsy syndrome (PSPS) [ 64 ], corticobasal syndrome (CBS) [ 64 ], and multiple system atrophy-parkinsonian type (MSA-P) [ 65 ]. COVID-19 has been reported to affect the international classification of functioning, disability, and health functioning in patients with MSA [ 66 ].…”