Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) are more prominent in retinal artery occlusion (RAO) compared to retinal vein occlusion (RVO)

Qin, Guanghao; He, Fang; Zhang, Hongda; Pazo, Emmanuel Eric; Dai, Guangzheng; Yao, Qingchi; He, Wei; Xu, Ling

doi:10.1371/journal.pone.0263587

Cited by 12 publications

(8 citation statements)

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“…Some authors have reported a significant association between higher PLR and RVO, suggesting that it could be used as a prediction biomarker for identifying the risk of RVO. [ 12 , 26 ] Higher pretreatment PLR levels are a significant prognostic factor in patients with macular edema secondary to RVO following anti-VEGF treatment and significantly associated with an effective visual outcome. [ 27 , 28 ] In the current study, PLR has the lowest AUC value (0.630) in predicting RVO according to ROC curve analysis and showed the lowest sensitivity among inflammatory indicators.…”

Section: Discussionmentioning

confidence: 99%

“…In many pathologies based on inflammation, inflammatory indicators obtained from peripheral blood are now used as prognostic markers and progression predictors of many diseases, including RVO. [7][8][9][10][11][12][13][14][15] This is the first study to evaluate systemic inflammation response index (SIRI) and monocyte-to-lymphocyte ratio (MLR) in elderly patients with RVO. The present study aims to determine the potential associations and the predictive value of inflammatory indicators such as the SIRI, neutrophil-tolymphocyte ratio (NLR), MLR, platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and other hematologic parameter characteristics in patients with RVO.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessment of systemic inflammatory response index and other inflammatory indicators in retinal vein occlusion

Üçer,

Cevher

2023

Medicine

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Retinal vein occlusion (RVO) is the second most common retinal vascular disease after diabetic retinopathy. The study aimed to evaluate the association and the predictive value of inflammatory indicators in RVO. Sixty patients with RVO and 60 healthy individuals were enrolled in this retrospective study. Inflammatory indicators and other hematological parameters obtained from the peripheral venous sample were analyzed and compared among groups. White blood cell count (P = .003), neutrophil (P < .001), neutrophil-to-lymphocyte ratio (NLR) (P < .001), monocyte-to-lymphocyte ratio (MLR) (P < .001), platelet-to-lymphocyte ratio (PLR) (P = .014), systemic immune-inflammation index (SII) (P < .001), and systemic inflammatory response index (SIRI) (P < .001) were significantly higher; the lymphocyte count (P < .001) was significantly lower in patients with RVO. According to receiver operating characteristic analysis, NLR was significant at the good level (area under the curve [AUC] = 0.817, P < .001); SIRI, SII, and MLR were significant at the fair level (AUC = 0.774, P < .001; AUC = 0.733, P < .001, and AUC = 0.724, P < .001, respectively) and PLR (AUC = 0.630, P = .014) was significant at the weak level in terms of RVO prediction. SIRI was superior to other indicators, except NLR, to predict RVO. SIRI, NLR, SII, MLR, and PLR can be used as predictors for identifying the risk of RVO.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessment of systemic inflammatory response index and other inflammatory indicators in retinal vein occlusion

Üçer,

Cevher

2023

Medicine

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“…[8][9][10][11][12][13] Furthermore, these serum inflammatory biomarkers have been linked to the onset of ocular disorders such as dry eye disease, keratoconus, retinal vein occlusion, and retinal artery occlusion. [14][15][16][17][18] While the role of NLR and PLR has been previously explored in iERM, [19,20] the current study aimed to evaluate the probable relationship between MLR, NLR, and PLR serum inflammatory biomarkers in participants with iERM.…”

Section: Introductionmentioning

confidence: 99%

Blood inflammatory biomarkers in participants with idiopathic epiretinal membrane: A retrospective case series study

Qin

You²,

Shang

et al. 2023

Medicine

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The objective was to evaluate the levels of monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with idiopathic epiretinal membrane (iERM). This retrospective case series study comprised of participants with iERM and participants with cataract. The values of MLR, NLR, PLR and from participants’ peripheral blood were assessed among groups. The best cutoff value of MLR, NLR, and PLR in iERM was found by performing a receiver operating characteristic curve analysis and determining the optimum cutoff value for each variable. In total, 95 participants with iERM were included in the study group, and 61 participants with senile cataract were included as controls. The lymphocyte count in the iERM group was significantly lower than the control group (1.69 ± 0.63 vs. 1.95 ± 0.53, P = .003). The monocyte count in the iERM group was significantly higher than the control group (0.39 ± 0.11 vs. 0.31 ± 0.10, P < .001). The area under the curve of MLR, NLR, and PLR in differentiating patients with IERM and controls was 0.782, 0.645, and 0.657, respectively, according to receiver operating characteristic. The best cutoff value of MLR was > 0.18, with sensitivity and specificity of 74.7% and 75.4%, respectively. The NLR was > 2.06, with a sensitivity and specificity of 50.5% and 83.6%, respectively. The PLR was > 95.89, with a sensitivity and specificity of 86.3% and 41.0%, respectively. The findings of this study suggest that systemic inflammation may be associated with iERM. IERM patients may be prone to have high MLR, NLR, and PLR values.

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“…As an inexpensive and convenient marker of in ammation, monocyte to lymphocyte ratio (MLR), neutrophil to lymphocytes ratio (NLR) and platelet to lymphocyte ratio (PLR) have gained increasing attention in various disorders such as multiple types of cancers, COVID-19, Alzheimer disease and acute coronary disease (CAD) [8][9][10][11][12][13]. Furthermore, these serum in ammatory biomarkers have been linked to the onset of ocular disorders such as dry eye disease (DED), keratoconus, retinal vein occlusion (RVO) and central retinal artery occlusions (CRVO) Page 3/12 [14][15][16][17][18]. While the role of NLR and PLR have been previously explored in iERM [19,20], the current study aimed to evaluate the probable relationship between MLR, NLR and PLR serum in ammatory biomarkers in participants with iERM.…”

Section: Introductionmentioning

confidence: 99%

Blood Inflammatory Biomarkers in Participants with Idiopathic Epiretinal Membranes Running Title: Blood Biomarkers for iERM

Qin

You²,

Shang

et al. 2022

Preprint

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Purpose: To evaluate the levels of monocyte to lymphocyte ratio (MLR), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in patients with Idiopathic Epiretinal Membrane (iERM). Methods:This retrospective study comprised of participants with iERM and participants with cataract. The values of MLR, NLR, PLR and from participants’ peripheral blood were assessed among groups. The best cutoff value of MLR, NLR, and PLR in iERM was found by performing a receiver operating characteristic (ROC) curve analysis and determining the optimum cutoff value for each variable. Results: In total, 95 participants with iERM were included in the study group, and 61 participants with senile cataract were included as controls. The lymphocyte count in the iERM group was significantly lower than the control group (1.69±0.63 vs. 1.95±0.53, p=0.003). The monocyte count in the iERM group was significantly higher thanthe control group (0.39±0.11 vs. 0.31±0.10, p<0.001). The area under the curve of MLR, NLR and PLR in differentiating patients with IERM and controls was 0.782, 0.645, and 0.657, respectively, according to ROC. The best cut-off value of MLR was >0.18, with sensitivity and specificity of 74.7% and 75.4% respectively. The NLR was >2.06, with a sensitivity and specificity of 50.5% and 83.6% respectively. The PLR was >95.89, with a sensitivity and specificity of 86.3% and 41.0% respectively. Conclusion:The findings of this study suggest that systemic inflammation may be associated with iERM. IERM patients may be prone to have high MLR, NLR and PLR values.

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Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) are more prominent in retinal artery occlusion (RAO) compared to retinal vein occlusion (RVO)

Cited by 12 publications

References 49 publications

Assessment of systemic inflammatory response index and other inflammatory indicators in retinal vein occlusion

Assessment of systemic inflammatory response index and other inflammatory indicators in retinal vein occlusion

Blood inflammatory biomarkers in participants with idiopathic epiretinal membrane: A retrospective case series study

Blood Inflammatory Biomarkers in Participants with Idiopathic Epiretinal Membranes Running Title: Blood Biomarkers for iERM

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