Neutrophil Viability in Down's Syndrome

Cocchi, P; Silenzi, M; Ravina, A

doi:10.1001/jama.1978.03290080027007

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…75 Several reports have documented impaired neutrophil function in DS. [76][77][78] Therefore, it is predicted that individuals with COVID-19 and DS would be at a higher risk of secondary bacterial lung infections during the COVID-19 pandemic.…”

Section: Increased Burden Of Secondary Bacterial Infectionsmentioning

confidence: 99%

Down Syndrome and COVID-19: A Perfect Storm?

Espinosa

2020

Cell Reports Medicine

110

132

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People with Down syndrome show signs of chronic immune dysregulation, including a higher prevalence of autoimmune disorders, increased rates of hospitalization during respiratory viral infections, and higher mortality rates from pneumonia and sepsis. At the molecular and cellular levels, they show markers of chronic autoinflammation, including interferon hyperactivity, elevated levels of many inflammatory cytokines and chemokines, and changes in diverse immune cell types reminiscent of inflammatory conditions observed in the general population. However, the impact of this immune dysregulation in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and CoV disease of 2019 (COVID-19) remains unknown. This Perspective outlines why individuals with Down syndrome should be considered an at-risk population for severe COVID-19. Specifically, the immune dysregulation caused by trisomy 21 may result in an exacerbated cytokine release syndrome relative to that observed in the euploid population, thus justifying additional monitoring and specialized care for this vulnerable population.

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Section: Increased Burden Of Secondary Bacterial Infectionsmentioning

confidence: 99%