Neutrophil volume, conductivity and scatter parameters with effective modeling of molecular activity statistical program gives better results in neonatal sepsis

Çelik, İstemi Han; Demırel, Gamze; Sukhachev, Dmitry; Erdeve, Ömer; Dilmen, Uğur

doi:10.1111/ijlh.12002

Cited by 16 publications

(11 citation statements)

References 16 publications

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“…Celik et al . suggested models using a combination of C‐reactive protein, the mean and standard deviation of neutrophil volume, and interleukin 6 levels for screening for sepsis.…”

Section: Introductionmentioning

confidence: 99%

“…Cell population data distributions are reported to be of some value in screening for infection or sepsis, both in adults and in children [1][2][3][4]. Most of the studies on such screening have focused on neutrophils, because these play the major role in immune responses against bacterial infections along with phagocytic and enzymatic bacterial destruction via lysosomes [1][2][3][4][5][6][7][8][9]. The mean neutrophil volume, standard deviation of neutrophil volume, and neutrophil conductivity are all increased in patients with infections [1][2][3][4][5][6][7]9].…”

Section: Introductionmentioning

confidence: 99%

“…Celik et al [5] showed that the mean volume, conductivity, and light scatter of neutrophils were useful in diagnosing sepsis and in assessing treatment in neonates. Celik et al [8] suggested models using a combination of C-reactive protein, the mean and standard deviation of neutrophil volume, and interleukin 6 levels for screening for sepsis.…”

Section: Introductionmentioning

confidence: 99%

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Cell population data in neonates: differences by age group and associations with perinatal factors

Lee

Kim

Lee

et al. 2015

Int J Lab Hematology

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“…Celik et al . suggested models using a combination of C‐reactive protein, the mean and standard deviation of neutrophil volume, and interleukin 6 levels for screening for sepsis.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cell population data in neonates: differences by age group and associations with perinatal factors

Lee

Kim

Lee

et al. 2015

Int J Lab Hematology

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“…Automated hematology analyzers yield several electronic and optical leukocyte indices like volumes of leukocyte subsets, cellular electrical conductivity, optical light scatter, etc. These have shown promise in early and sensitive diagnosis of diseases characterized by leukocytic abnormalities [3,[5][6][7][8][9]. The leukocyte differential in Beckman Coulter analyzers (Beckman Coulter, Miami, FL, USA) is based on VCS technology (volume, conductivity, and scatter) that quantifies leukocyte cell volume by voltage impedance (V); cytoplasmic and nuclear density by radio frequency conductivity (C); and cytoplasmic granularity and nuclear complexity by laser light scatter (S) [3].…”

mentioning

confidence: 99%

Elevated mean neutrophil volume+CRP is a highly sensitive and specific predictor of neonatal sepsis

Bhargava

Saluja

Sindhuri

et al. 2013

Int J Lab Hematology

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“…Using the percentages calculated by the automated cell counter (Beckman Coulter LH780 Analyzer, Beckman Coulter Inc. Diagnostic Division Headquarters, CA, USA) we determined the differentiated neutrophil and lymphocyte counts (11).…”

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confidence: 99%

Comparison of the Effects of Propofol Anaesthesia and Desflurane Anaesthesia on Neutrophil/Lymphocyte Ratios After Coronary Artery Bypass Surgery

2015

J Turgut Ozal Med Cent

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Objective: Coronary artery bypass surgery with cardiopulmonary bypass can induce postoperative systemic leukocytic alterations including leukocytosis, neutrophilia, or lymphopenia. The present study aims to compare the effects of propofol and desflurane anaesthesia on the leukocytic alterations including neutrophil-to-lymphocyte ratios after coronary artery bypass surgery. Materials and Methods: Sixty patients scheduled for coronary artery bypass surgery were randomly assigned into two groups: group P (n=30), which were anaesthesised with propofol (intravenous anaesthesia) and group D, which were anaesthesised with desflurane (inhalational anesthesia). Differential counts of leukocytes with neutrophil/lymphocyte ratios of peripheral blood were obtained just before anaesthesia induction (for basal values), at the postoperative 12th, 24th, and 48th hours. Results: At the postoperative 12th decrease in lymphocyte counts in group P was significantly lower than in group D (1.23 ± 0.81, 0.92 ± 1.01, respectively, with a p value of <0.001). Depending on this difference, neutrophil/lymphocyte ratios in group P were lower than in group D, which was statistically significant (11.21 ± 5.01, 22.81 ± 15.24, respectively, with a p value of <0.001). At postoperative 48th hour, it was seen that the statistically significant difference between groups on the basis of lymphocyte counts and neutrophil/lymphocyte ratios dissapeared. But a statistically significant difference appeared between the two groups on the basis of neutrophil counts (in group P 6.57 ± 2.05, in group D 10.20 ± 5.26; p<0.001) Conclusion: Comparing with desflurane anaesthesia, propofol anaesthesia favorably but transiently modifies leukocytic alterations, including neutrophil-to-lymphocyte ratios in peripheral blood during postoperative period of coronary artery bypass surgery. Key Words: Coronary Artery Surgery; Propofol And Desflurane Anesthesia; Neutrophil/Lymphocyte Ratio.Propofol ve Desfluran Anestezisinin Koroner Arter By-pass Cerrahisi Sonrası Nötrofil/Lenfosit Oranı Üzerine Etkilerinin Karşılaştırılması Özet Amaç: Kardiyopulmoner by-pass ile yapılan koroner arter by-pass cerrahisi lökositoz, nötrofili ve lenfopeniyi de içeren postoperatif lökosit dağılımı değişikliklerini başlatabilir. Bu çalışma ile kardiyopulmoner bypass kullanılarak koroner by-pass cerrahisine giden hastalarda propofol (intravenöz) ve desfluran (inhalasyon) anestezisinin postoperatif lökositik değişiklikler ve nötrofil/ lenfosit oranı üzerine etkileri incelenmiştir. Gereç ve Yöntemler: Bu prospektif randomize çalışmada elektif koroner arter by-pass cerrahisi planlanan 60 hasta iki eşit gruba randomize edildi. olgulardan 30'unda (grup P, n=30) propofol (intravenöz) anestezi ve diğer 30'unda ise (grup D, n=30) desfluran (inhalasyon anestezisi kullanıldı. Hastalardan lökosit alt tipleri ve nötrofil/lenfosit oranı tayini için anestezi indüksiyonundan hemen önce (bazal değer), postoperatif 12. saat, 24. saat ve 48. saatlerde olmak üzere periferik venden kan örneği alındı. Bulgular:...

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Neutrophil volume, conductivity and scatter parameters with effective modeling of molecular activity statistical program gives better results in neonatal sepsis

Abstract: We suggest to use the combination of MNV and VDW with markers such as CRP and IL-6, and use diagnostic models created by EMMA.

Cited by 16 publications

References 16 publications

Cell population data in neonates: differences by age group and associations with perinatal factors

Cell population data in neonates: differences by age group and associations with perinatal factors

Elevated mean neutrophil volume+CRP is a highly sensitive and specific predictor of neonatal sepsis

Comparison of the Effects of Propofol Anaesthesia and Desflurane Anaesthesia on Neutrophil/Lymphocyte Ratios After Coronary Artery Bypass Surgery

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