Neutrophilic dermatosis

Maalouf, Diane; Battistella, Maxime; Bouaziz, Jean‐David

doi:10.1097/moh.0000000000000100

Cited by 39 publications

(10 citation statements)

References 56 publications

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“…IL-8, which is also known as “neutrophil chemotactic factor”, plays a central role in neutrophil functions by inducing both chemotaxis and phagocytosis [ 28 ]. The mucocutaneous lesions (e.g., Pathergy reaction, pustular folliculitis) which are the hallmarks of BD, characteristically demonstrate significant neutrophilic infiltrates [ 29 – 31 ]. Additionally, IL-8 has previously shown to be increased in BD patients [ 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

Behçet's: A Disease or a Syndrome? Answer from an Expression Profiling Study

et al. 2016

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Behçet’s disease (BD) is a chronic, relapsing, multisystemic inflammatory disorder with unanswered questions regarding its etiology/pathogenesis and classification. Distinct manifestation based subsets, pronounced geographical variations in expression, and discrepant immunological abnormalities raised the question whether Behçet’s is “a disease or a syndrome”. To answer the preceding question we aimed to display and compare the molecular mechanisms underlying distinct subsets of BD. For this purpose, the expression data of the gene expression profiling and association study on BD by Xavier et al (2013) was retrieved from GEO database and reanalysed by gene expression data analysis/visualization and bioinformatics enrichment tools. There were 15 BD patients (B) and 14 controls (C). Three subsets of BD patients were generated: MB (isolated mucocutaneous manifestations, n = 7), OB (ocular involvement, n = 4), and VB (large vein thrombosis, n = 4). Class comparison analyses yielded the following numbers of differentially expressed genes (DEGs); B vs C: 4, MB vs C: 5, OB vs C: 151, VB vs C: 274, MB vs OB: 215, MB vs VB: 760, OB vs VB: 984. Venn diagram analysis showed that there were no common DEGs in the intersection “MB vs C” ∩ “OB vs C” ∩ “VB vs C”. Cluster analyses successfully clustered distinct expressions of BD. During gene ontology term enrichment analyses, categories with relevance to IL-8 production (MB vs C) and immune response to microorganisms (OB vs C) were differentially enriched. Distinct subsets of BD display distinct expression profiles and different disease associated pathways. Based on these clear discrepancies, the designation as “Behçet’s syndrome” (BS) should be encouraged and future research should take into consideration the immunogenetic heterogeneity of BS subsets. Four gene groups, namely, negative regulators of inflammation (CD69, CLEC12A, CLEC12B, TNFAIP3), neutrophil granule proteins (LTF, OLFM4, AZU1, MMP8, DEFA4, CAMP), antigen processing and presentation proteins (CTSS, ERAP1), and regulators of immune response (LGALS2, BCL10, ITCH, CEACAM8, CD36, IL8, CCL4, EREG, NFKBIZ, CCR2, CD180, KLRC4, NFAT5) appear to be instrumental in BS immunopathogenesis.

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Section: Discussionmentioning

confidence: 99%

Behçet's: A Disease or a Syndrome? Answer from an Expression Profiling Study

et al. 2016

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“…Metronidazole has been effective in patients whose dermatosis is related to inflammatory bowel disease [ 4 ]. Tumor necrosis factor (TNF) antagonists such as etanercept, infliximab, and thalidomide have been shown to be effective [ 4 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Histiocytoid Sweet’s syndrome in a patient with myelodysplastic syndrome: report and review of the literature

Shalaby

Riahi

Rosen

et al. 2016

Dermatol Pract Concept

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The neutrophilic dermatoses are a group of disorders characterized by skin lesions for which histological examination reveals intense epidermal and/or dermal inflammatory infiltrates composed primarily of neutrophils without evidence of infection. The myelodysplastic syndromes consist of a heterogeneous group of malignant hematopoietic stem cell disorders characterized by dysplastic and inadequate blood cell production with a variable risk of transformation to acute leukemia. Rarely, histiocytoid Sweet’s syndrome occurring in patients with myelodysplastic syndrome has been described. We present a case of a 66-year-old woman with a history of myelodysplastic syndrome who developed histiocytoid Sweet’s syndrome. We also review the literature and characterize patients with myelodysplastic syndrome who have developed histiocytoid Sweet’s syndrome.

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“…Often these diseases are associated with other autoimmune or inflammatory processes, such as inflammatory bowel disease [133, 134]. A variety of neutrophil functional defects, in chemotaxis, phagocytosis and other functions have been linked to various neutrophilic dermatoses, but as yet there is little molecular understanding of these processes.…”

Section: Roles For Neutrophils In Non-classical Autoinflammatory-lmentioning

confidence: 99%

Neutrophils in animal models of autoimmune disease

Németh

Mócsai

Lowell

2016

Seminars in Immunology

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Neutrophils have traditionally been thought to play only a peripheral role in the genesis of many autoimmune and inflammatory diseases. However, recent studies in a variety of animal models suggest that these cells are central to the initiation and propagation of autoimmunity. The use of mouse models, which allow either deletion of neutrophils or the targeting of specific neutrophil functions, has revealed the many complex ways these cells contribute to autoimmune/inflammatory processes. This includes generation of self antigens through the process of NETosis, regulation of T-cell and dendritic cell activation, production of cytokines such as BAFF that stimulate self-reactive B-cells, as well as indirect effects on epithelial cell stability. In comparing the many different autoimmune models in which neutrophils have been examined, a number of common underlying themes emerge – such as a role for neutrophils in stimulating vascular permeability in arthritis, encephalitis and colitis. The use of animal models has also stimulated the development of new therapeutics that target neutrophil functions, such as NETosis, that may prove beneficial in human disease. This review will summarize neutrophil contributions in a number of murine autoimmune/inflammatory disease models.

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Neutrophilic dermatosis

Cited by 39 publications

References 56 publications

Behçet's: A Disease or a Syndrome? Answer from an Expression Profiling Study

Behçet's: A Disease or a Syndrome? Answer from an Expression Profiling Study

Histiocytoid Sweet’s syndrome in a patient with myelodysplastic syndrome: report and review of the literature

Neutrophils in animal models of autoimmune disease

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