Neutrophilic dermatosis associated with mycosis fungoides

Morales-Moreno, Hector J.; Montenegro-Damaso, Társila; Peñate, Yeray

doi:10.1016/j.jdcr.2015.07.012

Cited by 2 publications

(2 citation statements)

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“…However, there are only 6 reported cases of MF-associated ND in the literature, and only 2 of them were observed in patients with transformed disease. The types of ND described in these cases vary, including pyoderma gangrenosum, neutrophilic hidradenitis, Sweet’s syndrome and exanthematous pustulosis ( 6 – 9 ). Sweet’s syndrome is the most common type of ND, characterized by fever, painful erythematous plaques with rapid onset, hyperleukocytosis, neutrophilia, massive neutrophilic dermal infiltrate in the histopathology, and a positive response to systemic corticosteroids ( 10 ).…”

Section: Discussionmentioning

confidence: 99%

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CD30+ Transformed Mycosis Fungoides Associated with Sweet-like Dermatosis

André¹,

Prins²,

Gillet³

et al. 2022

Acta Derm Venereol

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Section: Discussionmentioning

confidence: 99%

“…Development of ND has been shown to be a poor prognostic factor, regardless of the initial MF staging. All described patients died shortly after the diagnosis of ND ( 6 , 7 ).…”

Section: Discussionmentioning

confidence: 99%

CD30+ Transformed Mycosis Fungoides Associated with Sweet-like Dermatosis

André¹,

Prins²,

Gillet³

et al. 2022

Acta Derm Venereol

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Pustular mycosis fungoides has a poor outcome: a multicentric clinicopathological and molecular case series

Bontoux,

Badrignans,

Afach

et al. 2024

British Journal of Dermatology

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Background Mycosis fungoides (MF) has usually an indolent course. However, some patients develop a more aggressive disease and few prognostic parameters have been identified. Isolated cases of pustular MF (pMF) suggest an unfavourable prognosis. Objectives We aim to describe the clinico-pathological characteristics and prognostic value of pMF. Methods We retrospectively collected data of all cases of MF with histological pustules diagnosed from 2009 to 2020. The outcomes and clinico-pathological characteristics of pMF at diagnosis (pMFD) were compared to those of a cohort of non-pustular MF (NpMF). Results 33 pMF (including 22 pMFD) and 86 NpMF cases were included. The median age at diagnosis of pMF was 61 years [IQR=50-75]. The median follow-up of pMFD was 32 months [IQR=14-49]. Clinically, 33% of pMF had pustules. Large-cell transformation (LCT) occurred in 17 cases. pMFD were at a significantly more advanced-stage and more showed LCT at diagnosis than NpMF (50% vs 7%, p<0.001 and 23% vs 0%, p<0.001, respectively). In multivariate Cox analysis, the presence of histological pustule at diagnostic was associated with shorter OS in all patients (HR=13.90, CI95%[2.43-79]; p=0.003), and in early-stage patients (HR=11.09, CI95%[1.56-78.82]; p=0.02). In multivariate Fine and Gray model analysis, pMFD was associated with a higher cumulative incidence of LCT (SHR=13.90, CI95% [2.43-79]; p=0.003) in all patients. Median OS after the occurrence of histological pustules during follow-up of all pMF patients was 37 months, with a five-year OS of 25% (CI95% [0.06-0.5]). Conclusion pMF often follows an aggressive course, with a high risk of LCT and shorter survival, even for early-stage patients. Histological pustules at diagnostic of MF might represent an independent poor prognostic factor, to be confirmed by further studies. Because pustules are not always clinically identified, histological pustules should be mentioned in pathology reports of MF and prompt discussion of a closer follow-up.

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Neutrophilic dermatosis associated with mycosis fungoides

Cited by 2 publications

References 5 publications

CD30+ Transformed Mycosis Fungoides Associated with Sweet-like Dermatosis

CD30+ Transformed Mycosis Fungoides Associated with Sweet-like Dermatosis

Pustular mycosis fungoides has a poor outcome: a multicentric clinicopathological and molecular case series

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