Neutrophilic dermatosis caused by azathioprine hypersensitivity

Escribano-Stablé, J.C.; Pascual, JoséCarlos; Devesa, Pedro; Matarredona, Jaime; Hurtado-García, R.

doi:10.1111/j.1365-4632.2010.04827.x

Cited by 5 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our search revealed 18 cases that were reviewed and compiled ( Table 1 and Table 2). 5,[13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] Most affected patients (76.5%, n=13) had inflammatory bowel disease, similar to our patient. Treatment with azathioprine was started for 12 of 19 patients within 2 weeks of presentation ( Table 1).…”

Section: Discussionsupporting

confidence: 76%

Neutrophilic Dermatosis After Azathioprine Exposure

Cyrus¹,

Stavert²,

Mason³

et al. 2013

JAMA Dermatol

View full text Add to dashboard Cite

We report a case of azathioprine hypersensitivity syndrome and review the literature on azathioprine-induced eruptions with features of Sweet syndrome. Our patient's distribution of lesions on the extremities and the finding of suppurative folliculitis on histopathology were not classical for Sweet syndrome. Azathioprine hypersensitivity syndrome seems to be a neutrophil-driven dermatosis; therefore, many overlapping features with Sweet syndrome are not surprising. Due to the potential for anaphylaxis with azathioprine rechallenge, a better term for a Sweetlike presentation in the setting of azathioprine administration is azathioprine hypersensitivity syndrome.

show abstract

Section: Discussionsupporting

confidence: 76%

Neutrophilic Dermatosis After Azathioprine Exposure

Cyrus¹,

Stavert²,

Mason³

et al. 2013

JAMA Dermatol

View full text Add to dashboard Cite

show abstract

“…5 A literature search yielded 33 case reports published as AISS, of which 11 were excluded for the following reasons: to prevent duplication of data, 6,7 if they did not meet the criteria for drug-induced Sweet's syndrome, [8][9][10][11] or the rash and histology were more consistent with alternative neutrophilic dermatoses or erythema nodosum. 12,13 The remaining 22 published cases fulfilled the criteria for AISS; 16 of which were reported in patients with IBD (Table 1). IBD has a well-established association with Sweet's syndrome, 5 therefore its presence precludes a causal relationship with azathioprine.…”

Section: Discussion and Review Of The Literaturementioning

confidence: 98%

Azathioprine‐induced Sweet's syndrome: A case series and review of the literature

2015

View full text Add to dashboard Cite

We present three patients with azathioprine-induced Sweet's syndrome (AISS) who attended our tertiary institution within a 12-month period. Established associations exist between Sweet's syndrome and some medications; however, to date links to azathioprine are tentative. While there are case reports of AISS, most have occurred in patients with inflammatory bowel disease (IBD), an underlying predisposition for Sweet's syndrome. Our case series adds to the evidence that the entity of AISS truly exists independent of confounding factors such as concurrent IBD.

show abstract

Azathioprine

2013

Reactions Weekly

View full text Add to dashboard Cite

Neutrophilic dermatosis caused by azathioprine hypersensitivity

Cited by 5 publications

References 8 publications

Neutrophilic Dermatosis After Azathioprine Exposure

Neutrophilic Dermatosis After Azathioprine Exposure

Azathioprine‐induced Sweet's syndrome: A case series and review of the literature

Azathioprine

Contact Info

Product

Resources

About