Neutrophilic eccrine hidradenitis: Evidence implicating bleomycin as a causative agent

Scallan, Perry; Kettler, Anne H.; Levy, Moise L.; Tschen, Jaime A.

doi:10.1002/1097-0142(19881215)62:12<2532::aid-cncr2820621214>3.0.co;2-d

Cited by 51 publications

(14 citation statements)

References 12 publications

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“…1491,[1527][1528][1529][1530] The first reports concerned patients with acute myelogenous leukemia receiving cytarabine therapy, 1527,1531 but other cancers [1532][1533][1534][1535][1536] and other chemotherapeutic agents 1533,1537 have now been implicated, as has granulocyte colony-stimulating factor (G-CSF). 1491,[1527][1528][1529][1530] The first reports concerned patients with acute myelogenous leukemia receiving cytarabine therapy, 1527,1531 but other cancers [1532][1533][1534][1535][1536] and other chemotherapeutic agents 1533,1537 have now been implicated, as has granulocyte colony-stimulating factor (G-CSF).…”

Section: Neutrophilic Eccrine Hidradenitismentioning

confidence: 99%

Diseases of cutaneous appendages

Weedon

2010

Weedon's Skin Pathology

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Section: Neutrophilic Eccrine Hidradenitismentioning

confidence: 99%

Diseases of cutaneous appendages

Weedon

2010

Weedon's Skin Pathology

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“…ESSM may be clinically confused with sepsis, septic emboli, vasculitis, leukemia cutis, drug hypersensitivity urticaria, erythema multiforme, neutrophilic dermatoses such as Sweet's syndrome, bullous pyoderma gangrenosum, atypical pyoderma gangrenosum and lastly NEH 14 . The clinical confusion with herpes simplex, however, has not been reported before.…”

Section: Discussionmentioning

confidence: 99%

Eccrine syringosquamous metaplasia

et al. 2001

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A 7 year‐old male child presented with erythematous erosive plaques affecting the upper and lower eyelids of the left eye and extending to the cheek. Crustations over the right nostril were also evident. His general health status was normal. His medical history revealed that he was suffering from chronic myeloid leukemia for which he was receiving cyclic pulse therapy of cytarabine, doxorubicin and prednisone. It was noticed that the skin eruption was activated after each cycle and faded in 2–3 weeks to reappear after the next cycle but it never really cleared completely. The clinical differential diagnosis included herpes simplex, contact dermatitis, neutrophilic eccrine hidradenitis (NEH) and atypical fungal infection. The investigations included a complete blood count which showed a picture of improving leukemia with a total leucocytic count of 60 000/cc, RBCs count 3.7 × 106/cc, and platelet count of 110 000/cc. His hemoglobin was 9% The differential leucocytic count was as follows: basophils 0; eosinophils 4; blast cells 0; promyelocytes 0; myelocytes 10; juvenile cells 7; staff cells 14; segmented 45; lymphocytes 18 and monocytes 2. Cultures for fungi were negative, and serological examination for HIV, herpes simplex (IgG and IgM) cytomegalovirus and Epstein‐Barr virus antibodies were within normal ranges. Examination of a skin biopsy taken from the periorbital lesions revealed the presence of numerous islands of squamous cells extending from the epidermis into the upper‐ and mid‐dermis. Some of the islands were typically present around sweat ducts. On higher magnification, the cells forming the islands and lining the ducts were found to have abundant eosinophilic cytoplasm and large pale nuclei with prominent nucleoli. Some of the cells were dyskeratotic and there were occasional mitotic figures. Sparse lymphoid cell infiltrate was found surrounding some of the squamous cell islands. Based on the findings of squamous metaplasia of the cells lining the sweat ducts as well as the resemblance of some islands to squamous cell carcinoma, the diagnosis of eccrine syringosquamous metaplasia was made. Apart from the use of topical antibiotic creams, the patient received no therapy for his condition. Spontaneous improvement occured within 18 days after initial presentation but it recurred after the next cycle of chemotherapy.

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“…Since the original report, additional drug-associated cases have been reported with cytarabine, bleomycin, cyclophosphamide, mitoxanthrone, lomustine, zidovudine, and acetaminophen [15][16][17][18]. Infection-associated NEH has also been reported to occur in association with Serratia spp and Enterobacter cloacae, with culture positivity confirmed from skin lesions [15,19].…”

Section: Specific Cutaneous Eruptionsmentioning

confidence: 99%

Skin manifestations of drug reactions

Rosso

2002

Curr Allergy Asthma Rep

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Dermatologic manifestations of adverse drug reactions are commonly encountered in both hospital-based and ambulatory medical practice. Diagnosis is confounded by the myriad clinical presentations associated with cutaneous drug eruptions. Some presentations are highly characteristic, while others are not as straightforward, and may simulate other primary dermatoses. In many cases, patients are utilizing several medications and an obvious temporal relationship to a specific drug is not always apparent or expressed by the patient during disclosure of his or her medical history. A thorough medication history and a high index of suspicion are very important components in the diagnosis of drug eruptions.

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Neutrophilic eccrine hidradenitis: Evidence implicating bleomycin as a causative agent

Cited by 51 publications

References 12 publications

Diseases of cutaneous appendages

Diseases of cutaneous appendages

Eccrine syringosquamous metaplasia

Skin manifestations of drug reactions

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