Neutrophilic eccrine hidradenitis in a healthy Brazilian child

Arteaga, Julia Elisa Cabezas; Gonçalves, Daniel Luiz Marques; Giannotti, Marcelo Abrantes; Samorano, Luciana Paula

doi:10.1111/ddg.13890

Cited by 5 publications

(4 citation statements)

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“…Recently, NEH has been reported with infliximab, ticagrelor, and pegfilgrastim [128][129][130]. In healthy children, NEH is an idiopathic benign, self-limited eruption that tends to occur in summer months called idiopathic plantar hidradenitis (IPH) [131]. In these cases, it is hypothesized that the combination of trauma and high temperatures provoke sweat gland rupture leading to an inflammatory cascade and neutrophilic recruitment [132].…”

Section: Epidemiologymentioning

confidence: 99%

Neutrophilic Dermatoses: a Clinical Update

Weiss

Leung

et al. 2022

Curr Derm Rep

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Purpose of Review Neutrophilic dermatoses are defined by the presence of a sterile neutrophilic infiltrate on histopathology. This review focuses on the pathogenesis, epidemiology, clinicopathological features, diagnosis, and management of four disorders: Sweet syndrome, pyoderma gangrenosum, Behçet syndrome, and neutrophilic eccrine hidradenitis.Recent Findings Recent studies have provided insight into the complex pathogenesis of neutrophilic dermatoses. Evidence supports an intricate interplay of abnormal neutrophil function and inflammasome activation, malignant transformation into dermal infiltrating neutrophils, and genetic predisposition. Summary Neutrophilic dermatoses have diverse cutaneous and extracutaneous manifestations and may be associated with significant morbidity and mortality. Common underlying associations include infectious, inflammatory, and neoplastic disorders, as well as drug reactions. Emerging diagnostic and therapeutic frameworks identify an expanding role for biologic and targeted anti-inflammatory therapies. KeywordsAcute febrile neutrophilic dermatosis • Behçet disease • Neutrophilic dermatosis • Neutrophilic eccrine hidradenitis • Pyoderma gangrenosum • Sweet syndrome This article is part of the Topical Collection on Hospital-Based Dermatology

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Section: Epidemiologymentioning

confidence: 99%

Neutrophilic Dermatoses: a Clinical Update

Weiss

Leung

et al. 2022

Curr Derm Rep

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“…Histologically, the sterile, neutrophil‐rich infiltrate can be localized in the epidermis, dermis or even the subcutis. Neutrophilic dermatoses include a multitude of different clinical entities such as pyoderma gangraenosum, acute febrile neutrophilic dermatosis (Sweet Syndrome), neutrophil eccrine hidradenitis, rheumatoid neutrophil dermatitis, interstitial granulomatous dermatitis, acute generalized exanthematous pustulosis and generalized pustular psoriasis, among others 1–5 . While these disease entities present distinct differences in terms of their clinical classification and may appear to bear little relationship to one another, they share significant similarities when it comes to their pathogenesis, which may be exploited therapeutically.…”

Section: Introductionmentioning

confidence: 99%

Neutrophilic dermatoses – Pathomechanistic concepts and therapeutic developments

Bonnekoh

Erpenbeck

2023

J Deutsche Derma Gesell

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SummaryNeutrophilic dermatoses are a group of clinically heterogeneous diseases characterized by infiltration of neutrophils in the affected tissue. Skin symptoms comprise a spectrum of wheals, papules, plaques, pustules, nodules and ulcerations often in combination with systemic symptoms. Although the pathogenesis of these diseases has not yet been elucidated in depth, broad pathophysiological and clinical overlaps exist with autoinflammatory syndromes. Additionally, recent years have shown the relevance of the signaling pathways of TNF‐α, IL‐1, IL‐12/23 and IL‐17 in neutrophilic dermatoses. In this review, we present four selected neutrophilic dermatoses, namely pyoderma gangraenosum, Sweet syndrome, generalized pustular psoriasis and Schnitzler syndrome, discuss pathophysiological aspects and specifically address novel therapeutic options derived from the most recent pathophysiological findings.

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“…Histologisch kann das sterile, neutrophilenreiche Infiltrat in der Epidermis, der Dermis oder sogar der Subkutis lokalisiert sein. Neutrophile Dermatosen umfassen eine Vielzahl verschiedener klinischer Entitäten, unter anderem das Pyoderma gangraenosum, die akute febrile neutrophile Dermatose (Sweet‐Syndrom), die neutrophile ekkrine Hidradenitis, die rheumatoide neutrophile Dermatitis, die interstitielle granulomatöse Dermatitis, die akute generalisierte exanthematische Pustulose und die generalisierte pustulöse Psoriasis 1–5 . Obwohl sich diese Krankheitsbilder in ihrer klinischen Klassifizierung deutlich unterscheiden und scheinbar wenig miteinander zu tun haben, weisen sie in ihrer Pathogenese erhebliche Ähnlichkeiten auf, die therapeutisch genutzt werden können.…”

Section: Introductionunclassified

Neutrophile Dermatosen – Pathomechanistische Konzepte und therapeutische Entwicklungen

Bonnekoh

Erpenbeck²

2023

J Deutsche Derma Gesell

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ZusammenfassungNeutrophile Dermatosen sind eine Gruppe von klinisch heterogenen Erkrankungen, die durch eine Infiltration von Neutrophilen im betroffenen Gewebe gekennzeichnet sind. Die Hautsymptome umfassen ein Spektrum von Quaddeln, Papeln, Plaques, Pusteln, Knoten und Ulzerationen, oft in Kombination mit systemischen Symptomen. Obwohl die Pathogenese dieser Krankheiten noch nicht vollständig geklärt ist, gibt es breite pathophysiologische und klinische Überschneidungen mit autoinflammatorischen Syndromen. Darüber hinaus haben die letzten Jahre die Bedeutung der Signalwege von TNF‐α, IL‐1, IL‐12/23 und IL‐17 bei neutrophilen Dermatosen gezeigt. In dieser Übersichtsarbeit stellen wir vier ausgewählte neutrophile Dermatosen vor, namentlich das Pyoderma gangraenosum, das Sweet‐Syndrom, die generalisierte pustulöse Psoriasis und das Schnitzler‐Syndrom. Wir erörtern pathophysiologische Aspekte und gehen speziell auf neue therapeutische Optionen ein, die sich aus den aktuellen pathophysiologischen Erkenntnissen ergeben.

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Neutrophilic eccrine hidradenitis in a healthy Brazilian child

Cited by 5 publications

References 0 publications

Neutrophilic Dermatoses: a Clinical Update

Neutrophilic Dermatoses: a Clinical Update

Neutrophilic dermatoses – Pathomechanistic concepts and therapeutic developments

Neutrophile Dermatosen – Pathomechanistische Konzepte und therapeutische Entwicklungen

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