Neutrophils enhance invasion activity of human cholangiocellular carcinoma and hepatocellular carcinoma cells: An <i>in vitro</i> study

Imai, Yoshiyuki; Kubota, Yoshihiro; Yamamoto, Shin; Tsuji, Kazuyuki; Shimatani, Masaaki; Shibatani, Nobuyuki; Takamido, Shoichiroh; Matsushita, Makoto; Okazaki, Kazuichi

doi:10.1111/j.1440-1746.2004.03575.x

Cited by 60 publications

(36 citation statements)

References 20 publications

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“…(HGF) from neutrophils, which promoted increased invasiveness by the tumor cells (16). These findings suggest that, although neutrophils release a paucity of cytokine when compared with macrophages and other cells within the tumor microenvironment, the temporal-spatial elaboration of these substances by PMN plays unique roles.…”

Section: Neutrophil-derived Cytokines Participate In Immunosculptingmentioning

confidence: 82%

Tumor-Associated Neutrophils: New Targets for Cancer Therapy

2011

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Studies have begun to emerge showing critical roles for neutrophils in tumorigenesis. Neutrophils can have a significant impact on the tumor microenvironment via their production of cytokines and chemokines, which influence inflammatory cell recruitment and activation. Additionally, products secreted from neutrophils, such as reactive oxygen species and proteinases, have defined and specific roles in regulating tumor cell proliferation, angiogenesis, and metastasis. Although evidence suggests that neutrophils act in a decidedly protumor capacity in vivo, recent studies indicate that neutrophils may be manipulated to exhibit cytotoxicity against tumors. Herein, we explore the idea of targeting tumor-associated neutrophils as a means of antitumor therapy and the important ramifications such manipulation could pose to host tissues. Cancer Res; 71(7); 2411-6. Ó2011 AACR.

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Section: Neutrophil-derived Cytokines Participate In Immunosculptingmentioning

confidence: 82%

Tumor-Associated Neutrophils: New Targets for Cancer Therapy

2011

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“…Neutrophils in bronchioloalveolar carcinoma produce hepatocyte growth factor (HGF) that stimulates the migration of the tumor cells [203]. Similarly, human cholangiocellular and hepatocellular carcinoma cells induce HGF secretion by neutrophils, which in turn enhances the invasiveness of the cancer cells [288]. TANs can also stimulate tumor growth by releasing growth factors such as epidermal growth factor, TGFβ and platelet-derived growth factor (PDGF) from the extracellular matrix [289].…”

Section: Neutrophils At the Primary Tumor Sitementioning

confidence: 99%

The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment

Sionov

Fridlender

Granot

2014

Cancer Microenvironment

342

261

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Neutrophils are myeloid cells that constitute 50-70 % of all white blood cells in the human circulation. Traditionally, neutrophils are viewed as the first line of defense against infections and as a major component of the inflammatory process. In addition, accumulating evidence suggest that neutrophils may also play a key role in multiple aspects of cancer biology. The possible involvement of neutrophils in cancer prevention and promotion was already suggested more than half a century ago, however, despite being the major component of the immune system, their contribution has often been overshadowed by other immune components such as lymphocytes and macrophages. Neutrophils seem to have conflicting functions in cancer and can be classified into anti-tumor (N1) and pro-tumor (N2) sub-populations. The aim of this review is to discuss the varying nature of neutrophil function in the cancer microenvironment with a specific emphasis on the mechanisms that regulate neutrophil mobilization, recruitment and activation.

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“…Neutrophils are attracted into lesions by tumor IL-8 production and once in the tumor microenvironment, neutrophils produce many factors that sculpt the tumor [60]. Imai and colleagues observed that neutrophils augment the invasiveness of tumor cells during coculture one effect that was completely blocked by the inclusion of a monoclonal anti-hepatocyte growth factor (HGF) antibody [61]. Subsequent experiments revealed that the tumor cells produced a factor that induced HGF production by the neutrophils, again demonstrating a mutually beneficial interaction between tumor and immune effect.…”

Section: C121 Immune Effectors Can Simultaneously Sculpt Tumors Fmentioning

confidence: 99%

Tumor immunoediting and immunosculpting pathways to cancer progression

Reiman

Kmieciak

Manjili

et al. 2007

Seminars in Cancer Biology

171

130

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Recent studies have suggested that a natural function of the immune system is to respond and destroy aberrant, dysfunctional cells by a process called immunosurveillance. These studies also suggest that the tumors that arise despite immunosurveillance have been immunosculpted by the immune system. The purported abilities of tumors to induce immune tolerance and suppression, the increased pathogenic behavior of the tumor cells following exposure to immune effectors and the loss of immunogenicity (i.e. immunoediting) often observed in advanced stage tumors could be the result of immunosculpting. In some cases, these immunosculpting features may be permanent and irreversible. However, in other cases, reversible epigenetic mechanisms may underlie the immune resistant tumor phenotype. Regardless, these immune-induced alterations could contribute to cancer pathogenesis. Understanding the mechanisms by which tumors evade immunity will be important for disease prevention and therapeutics.

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Neutrophils enhance invasion activity of human cholangiocellular carcinoma and hepatocellular carcinoma cells: An in vitro study

Abstract: The present study suggests the presence of mutual interactions between HuCC-T1/HepG2 carcinoma cells and neutrophils in tumor invasion via paracrine regulation mediated by neutrophil-derived HGF.

Cited by 60 publications

References 20 publications

Tumor-Associated Neutrophils: New Targets for Cancer Therapy

Tumor-Associated Neutrophils: New Targets for Cancer Therapy

The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment

Tumor immunoediting and immunosculpting pathways to cancer progression

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