2014
DOI: 10.1016/j.jaci.2014.05.040
|View full text |Cite
|
Sign up to set email alerts
|

Neutrophils in antiretroviral therapy–controlled HIV demonstrate hyperactivation associated with a specific IL-17/IL-22 environment

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

6
32
0

Year Published

2015
2015
2019
2019

Publication Types

Select...
7
2

Relationship

1
8

Authors

Journals

citations
Cited by 42 publications
(38 citation statements)
references
References 55 publications
6
32
0
Order By: Relevance
“…Of note, increased IL-17 production by classical and nonclassical T cells is an increasingly recognized feature in HIV patients. 56,57 In conclusion, we have identified a novel function of PMPs to selectively bind a specialized subset of T H 17-like progenitor cells in the Treg compartment and inhibit their differentiation into potentially pathogenic effector cells. The direct involvement of the cell adhesion molecule P-selectin and its ligand PSGL-1 in this process suggests a role for PMPs in wound healing by participating in the regulation of the required inflammatory response.…”
Section: Discussionmentioning
confidence: 91%
“…Of note, increased IL-17 production by classical and nonclassical T cells is an increasingly recognized feature in HIV patients. 56,57 In conclusion, we have identified a novel function of PMPs to selectively bind a specialized subset of T H 17-like progenitor cells in the Treg compartment and inhibit their differentiation into potentially pathogenic effector cells. The direct involvement of the cell adhesion molecule P-selectin and its ligand PSGL-1 in this process suggests a role for PMPs in wound healing by participating in the regulation of the required inflammatory response.…”
Section: Discussionmentioning
confidence: 91%
“…Neutrophils have been demonstrated recently to produce both IL-17 and IL-22 under various inflammatory/infectious conditions (9, 10, 19, 45). However, it is still unclear how neutrophil production of these cytokines is regulated.…”
Section: Discussionmentioning
confidence: 99%
“…22 To investigate the senescent C-X-C chemokine receptor type 4 (CXCR4) high /CD62L low neutrophil subset, samples kept on ice were incubated for 45 minutes with phycoerythrin (PE)/cyanine 7 (Cy7)/antihuman CXCR4 (clone 12G5; Sony Biotech, San Jose, CA), PE/antihuman CD11b (clone ICRF44; BD Biosciences, San Jose, CA), and allophycocyanin (APC)/antihuman CD62L (BD Biosciences). 23 Samples were analyzed by flow cytometry.…”
Section: Determination Of Surface Molecule Expression On Resting Neutmentioning
confidence: 99%