Neutrophils in Psoriasis

Chiang, Chen‐Yu; Cheng, Wei-Jen; Korinek, Michal; Lin, Cheng‐Yu; Hwang, Tsong‐Long

doi:10.3389/fimmu.2019.02376

Cited by 192 publications

(176 citation statements)

References 155 publications

(188 reference statements)

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“…We demonstrated that there are progressive changes in the degree of extra-cutaneous impact among patients with psoriasis. For example MPO is elevated in 73% of patients, likely reflecting vascular uptake from areas in the dermis where high concentrations of MPO are released by myeloid cells [42]. In addition, mediators from the dermis reaching the vasculature may be triggering PMN-derived and monocyte-derived MPO release [43].…”

Section: Discussionmentioning

confidence: 99%

Psoriasis and Psoriatic Arthritis Cardiovascular Disease Endotypes Identified by Red Blood Cell Distribution Width and Mean Platelet Volume

Conic

Damiani

Schrom

et al. 2020

JCM

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In a subset of psoriasis (PsO) and psoriatic arthritis (PsA) patients, the skin and/or joint lesions appear to generate biologically significant systemic inflammation. Red cell distribution width (RDW) and mean platelet volume (MPV) are readily available clinical tests that reflect responses of the bone marrow and/or plasma thrombogenicity (e.g., inflammation), and can be markers for major adverse cardiac events (MACE). We aimed to evaluate if RDW and MPV may be employed as inexpensive, routinely obtained biomarkers in predicting myocardial infarction (MI), atrial fibrillation (AF), and chronic heart failure (CHF) in psoriatic and psoriatic arthritis patients. The study was divided into two parts: (a) case control study employing big data (Explorys) to assess MPV and RDW in psoriasis, psoriatic arthritis and control cohorts; (b) a clinical observational study to validate the predictive value of RDW and to evaluate RDW response to anti-psoriatic therapies. We used Explorys, an aggregate electronic database, to identify psoriatic patients with available MPV and RDW data and compared them to gender and age matched controls. The incidence of myocardial infarction (MI), atrial fibrillation (AF), and chronic heart failure (CHF) was highest among patients with both elevated RDW and MPV, followed by patients with high RDW and normal MPV. RDW elevation among PsA patients was associated with an increased risk of MI, AF, and CHF. In a local clinical cohort, high RDWs were concentrated in a subset of patients who also had elevated circulating resistin levels. Among a small subset of participants who were treated with various systemic and biologic therapies, and observed over a year, and in whom RDW was elevated at baseline, a sustained response to therapy was associated with a decrease in RDW. RDW and MPV, tests commonly contained within routine complete blood count (CBC), may be a cost-effective manner to identify PsO and PsA patients at increased risk of MACE.

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Section: Discussionmentioning

confidence: 99%

Psoriasis and Psoriatic Arthritis Cardiovascular Disease Endotypes Identified by Red Blood Cell Distribution Width and Mean Platelet Volume

Conic

Damiani

Schrom

et al. 2020

JCM

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“…Neutrophil inflammatory responses may be considered a double-edged sword; although they protect against infection, they also cause severe tissue damage. Activated neutrophils are involved in many acute and chronic inflammatory diseases as well as autoimmune disorders, such as respiratory diseases (ARDS, COPD, and asthma), cardiovascular diseases (atherosclerosis and thrombosis) ( Németh et al, 2020 ), gastrointestinal diseases (inflammatory bowel disease and autoimmune hepatitis) ( Honda and Kubes, 2018 ), neurological diseases (multiple sclerosis and Alzheimer’s disease) ( Dong et al, 2018 ; Woodberry et al, 2018 ), skin diseases (psoriasis and Behçet’s disease) ( Safi et al, 2018 ; Chiang et al, 2019 ), and metabolic diseases (diabetes mellitus and obesity) ( Talukdar et al, 2012 ; Brotfain et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Targeting Neutrophils to Treat Acute Respiratory Distress Syndrome in Coronavirus Disease

et al. 2020

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This review describes targeting neutrophils as a potential therapeutic strategy for acute respiratory distress syndrome (ARDS) associated with coronavirus disease 2019 (COVID-19), a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Neutrophil counts are significantly elevated in patients with COVID-19 and significantly correlated with disease severity. The neutrophil-to-lymphocyte ratio can serve as a clinical marker for predicting fatal complications related to ARDS in patients with COVID-19. Neutrophil-associated inflammation plays a critical pathogenic role in ARDS. The effector functions of neutrophils, acting as respiratory burst oxidants, granule proteases, and neutrophil extracellular traps, are linked to the pathogenesis of ARDS. Hence, neutrophils can not only be used as pathogenic markers but also as candidate drug targets for COVID-19 associated ARDS.

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“…While activation of mast cells by IL-1 was an important process in skin in ammation and implicated in psoriasis pathogenesis [18] . Recent studies revealed that neutrophils in psoriatic plaque generated abundant neutrophil extracellular trap, degranulation and the respiratory burst with ROS production, contributing to the pathogenesis of psoriasis [19] . Collectively, different innate immune cells in ltrated in skin could play various roles in psoriasis development and progression.…”

Section: Discussionmentioning

confidence: 99%

Profiles of Innate Immune Cell Infiltration and Related Core Genes in Psoriasis

Gong

Wang

2020

Preprint

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Background: Psoriasis is an inflammatory skin disease with substantial morbidity. Numerous patients with psoriasis experience recurrence after therapy. The underlying mechanism about psoriasis is still not fully understood. Some evidences suggest that innate immunity may play an unexpected and important role in active severe psoriasis. In this work, the deconvolution algorithm CIBERSORT was conducted to identify the infiltration of innate immune cells and related core genes in psoriatic plaque.Results: Datasets from the Gene Expression Omnibus, including 407 psoriasis lesional, 373 non-lesional and 91 normal skin samples, were downloaded for analysis. Considerable differences of the innate immune cell composition were uncovered between psoriatic plaque and control skin. Results revealed that γδ T cells, resting NK cells, M0 macrophages, M1 macrophages, activated dendritic cells and neutrophils were significantly increased in psoriatic skin, while resting mast cells and active NK cells were significantly decreased. Moreover, the proportion of M0 macrophages or resting mast cells was found to be associated with disease severity. Spearman correlation analysis suggests that RORC and S100A12 genes were related to disease severity, while genes including S100A12, CLEC4C, IL-19, AIM2, IL-17F, PPARGC1A, were correlated with biologics treatment response.Conclusions: Collectively, this work displays innate immune status in psoriatic skin, and provides novel clues for clinical decisions and mechanism study.

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Neutrophils in Psoriasis

Cited by 192 publications

References 155 publications

Psoriasis and Psoriatic Arthritis Cardiovascular Disease Endotypes Identified by Red Blood Cell Distribution Width and Mean Platelet Volume

Psoriasis and Psoriatic Arthritis Cardiovascular Disease Endotypes Identified by Red Blood Cell Distribution Width and Mean Platelet Volume

Targeting Neutrophils to Treat Acute Respiratory Distress Syndrome in Coronavirus Disease

Profiles of Innate Immune Cell Infiltration and Related Core Genes in Psoriasis

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