Neutrophils only die twice

Souza, Fernando W.; Miao, Edward A.

doi:10.1126/sciadv.adm8715

Sci. Adv.

2023

DOI: 10.1126/sciadv.adm8715

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Neutrophils only die twice

Fernando W. Souza,

Edward A. Miao

Abstract: After apoptotic cell death begins neutrophils initiate NETosis, a second cell death program.

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2024

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Neutrophil diversity and function in health and disease

Zhang,

Xia,

et al. 2024

Sig Transduct Target Ther

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Neutrophils, the most abundant type of granulocyte, are widely recognized as one of the pivotal contributors to the acute inflammatory response. Initially, neutrophils were considered the mobile infantry of the innate immune system, tasked with the immediate response to invading pathogens. However, recent studies have demonstrated that neutrophils are versatile cells, capable of regulating various biological processes and impacting both human health and disease. Cytokines and other active mediators regulate the functional activity of neutrophils by activating multiple receptors on these cells, thereby initiating downstream signal transduction pathways. Dysfunctions in neutrophils and disruptions in neutrophil homeostasis have been implicated in the pathogenesis of numerous diseases, including cancer and inflammatory disorders, often due to aberrant intracellular signaling. This review provides a comprehensive synthesis of neutrophil biological functions, integrating recent advancements in this field. Moreover, it examines the biological roles of receptors on neutrophils and downstream signaling pathways involved in the regulation of neutrophil activity. The pathophysiology of neutrophils in numerous human diseases and emerging therapeutic approaches targeting them are also elaborated. This review also addresses the current limitations within the field of neutrophil research, highlighting critical gaps in knowledge that warrant further investigation. In summary, this review seeks to establish a comprehensive and multidimensional model of neutrophil regulation, providing new perspectives for potential clinical applications and further research.

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Neutrophil diversity and function in health and disease

Zhang,

Xia,

et al. 2024

Sig Transduct Target Ther

View full text Add to dashboard Cite

show abstract

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Neutrophils only die twice

Abstract: After apoptotic cell death begins neutrophils initiate NETosis, a second cell death program.

Cited by 1 publication

References 11 publications

Neutrophil diversity and function in health and disease

Neutrophil diversity and function in health and disease

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