1999
DOI: 10.1016/s0009-9236(99)80079-4
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Nevirapine induces both CYP3A4 and CYP2B6 metabolic pathways

Abstract: Clinical Pharmacology & Therapeutics (1999) 65, 137–137; doi:

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Cited by 41 publications
(36 citation statements)
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“…Likewise, all the intended macrolides exhibited inhibitory effects on CYP3A4 at several levels (Table 2). Compared to previous studies using human liver microsomes (HLMs), the inhibitory concentration for INH presented here was evidently low (IC 50 , 0.9 M) ( Table 2) (23, 24). Both PZA and EMB exerted no effects on CYP3A4 at any given concentration (see Table S1 in the supplemental material).…”
Section: Resultscontrasting
confidence: 88%
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“…Likewise, all the intended macrolides exhibited inhibitory effects on CYP3A4 at several levels (Table 2). Compared to previous studies using human liver microsomes (HLMs), the inhibitory concentration for INH presented here was evidently low (IC 50 , 0.9 M) ( Table 2) (23, 24). Both PZA and EMB exerted no effects on CYP3A4 at any given concentration (see Table S1 in the supplemental material).…”
Section: Resultscontrasting
confidence: 88%
“…Hence, we inferred that the DDIs between NVP and CYP3A4 modulators, such as azoles, HIV protease inhibitors, and oral contraceptives, would depend on CYP2B6 induction by NVP, because these CYP3A4 modulators have been proven to be substrates for CYP2B6 (29,48,49). However, the increased metabolism of ERY mediated by NVP cannot be explained with this hypothesis, because macrolides have no bearing on CYP2B6 activities (data not shown) (50). In the light of previous studies, NVP might exhibit both inductive and inhibitory effects on CYP3A4 activity on a case-by-case basis (47).…”
Section: Discussionmentioning
confidence: 96%
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“…Ethambutol is included in the continuation phase in those patients who have had a previous episode of TB. Nevirapine is both metabolized by and induces cytochrome P450 (CYP) isoenzymes 3A4 and 2B6 [3]. The plasma concentrations of nevirapine initially decrease after the start of therapy due to auto-induction, reaching a steady state during the second week of treatment [3,4].…”
Section: Introductionmentioning
confidence: 99%
“…Nevirapine is both metabolized by and induces cytochrome P450 (CYP) isoenzymes 3A4 and 2B6 [3]. The plasma concentrations of nevirapine initially decrease after the start of therapy due to auto-induction, reaching a steady state during the second week of treatment [3,4]. Rifampicin is a potent inducer of CYP3A4 and increases the expression of CYP2B6 [5,6].…”
Section: Introductionmentioning
confidence: 99%