1986
DOI: 10.1016/s0190-9622(86)70266-1
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Nevoid basal cell carcinoma syndrome

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1988
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Cited by 75 publications
(5 citation statements)
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“…The pits are usually 1∼3 mm in depth and 2∼3 mm in diameter, and they usually develop in the second decade. Their number can increase up to 500 or more with age[ 29 ]. A pit itself is not malignant, but continuous observation is required because a pit may result in BCCs occurring in the hands and feet.…”
Section: Discussionmentioning
confidence: 99%
“…The pits are usually 1∼3 mm in depth and 2∼3 mm in diameter, and they usually develop in the second decade. Their number can increase up to 500 or more with age[ 29 ]. A pit itself is not malignant, but continuous observation is required because a pit may result in BCCs occurring in the hands and feet.…”
Section: Discussionmentioning
confidence: 99%
“…Although it is true that multiple BFH may also be noted, intermingled with other adnexal skin tumours, in patients with Gorlin syndrome (22,25), we emphasize that the gestalt of clinical and histopathological features of Gorlin syndrome is quite different from the syndrome described here, which is why the phenotype of Gorlin syndrome can be distinguished easily even in its mosaic forms (26). In some difficult cases (27), DNA analysis of PTCH may be helpful to rule out, or ascertain, Gorlin syndrome. So far, however, molecular proof of mosaicism has not been provided in such patients.…”
Section: Differential Diagnosismentioning
confidence: 51%
“…BCCs most often appear between puberty and 35 years of age; the mean age of onset is about 25 years of age [8]. Between 30% and 65% of patients with the syndrome have small asymmetric palmar or plantar pits by the age of 10 years; this percentage rises to 80% by the age of 15 years [7,38]. The calcification of the falx cerebri can appear very early in life, and is often strikingly apparent from late childhood.…”
Section: Discussionmentioning
confidence: 99%