Nevus compuesto inflamatorio juvenil: no es melanoma todo lo que parece

Oteyza, G. García de; Betancourt, J Amador; Sandner, M. Benedetti; Vázquez-Romo, K.A.; Hernández-Ayuso, Ivette; Ramos-Betancourt, Nallely

doi:10.1016/j.oftal.2018.06.022

Cited by 4 publications

(5 citation statements)

References 9 publications

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“…It has been described that conjunctival nevi appear in the first and second decades of life with the nevomelanocytic cell nests located in the epidermal-stromal junction, and during the second and third decade the nests migrate to the stroma forming the compound nevus. In the third and fourth decade the lesion usually is totally located in the subepithelial stroma [1], [3]. This fact could explain why in our series the older group presented higher percentage of stromal component in the lesion.…”

Section: Discussionmentioning

confidence: 68%

“…After reviewing the scant studies and reports about IJCN, we realized that there are not clearly defined diagnostic criteria for this entity. Most of the authors define this entity as a lesion with “reverse” maturation, confluent growth pattern in the junctional component, chronic inflammation and variable but low grade of cytologic atypia [3], [8], [9]. After the review of our cases and considering the lack of unification of diagnostic criteria reported in the literature, it is unclear if any of our cases could finally be diagnosed as IJCN.…”

Section: Discussionmentioning

confidence: 96%

“…Cystic inclusions are considered a sign of chronicity and are caused by the migration of subepidermal melanocytes [3]. Of the five cases that do not show intraepithelial inclusions (solid or cystic), four correspond to the group of patients of thirty or less years old.…”

Section: Discussionmentioning

confidence: 99%

“…The most important clinical and histological differential diagnosis is conjunctival malignant melanoma, whose clinical presentation can be similar to IJCN. However, cysts are rarely seen in melanomas, and unlike malignant melanoma, in IJCN there is no marked cytological atypia or mitotic activity in the stromal component [3].…”

Section: Introductionmentioning

confidence: 99%

“…This neoplasm appears most frequently in the bulbar conjunctiva (72%) [2]. Progression to melanoma has only been described in 1% of cases [3].…”

Section: Introductionmentioning

confidence: 99%

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Search for histopathological characteristics of inflammatory juvenile conjunctival nevus in conjunctival nevi related to age: Analysis of 33 cases

Nebot

Sáez

Serret

et al. 2019

Saudi Journal of Ophthalmology

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PurposeConjunctival nevi in young individuals can correspond to the entity named Inflammatory Juvenile Conjunctival Nevus (IJCN), presenting clinically as a rapid growth lesion, and showing at the histopathological study an inflammatory infiltrate surrounding the lesion. All these findings can suggest a diagnosis of malignancy. Due to a case of IJCN diagnosed in our Pathology department, we realized that this entity is rarely reported in the literature and histopathological diagnostic criteria are not well defined. The aim of our study is to compare the histopathological characteristics of conjunctival nevi in patients aged thirty years or less to those in patients above 30 years, looking for the findings described in IJCN.MethodsAll the excisional specimens of resected conjunctival nevus in a tertiary hospital from 2000 to 2018 were retrieved from the Pathology department archives. Demographic data were recorded, and histopathological variables (histological type of nevus, lymphocytic infiltration, eosinophilic infiltration, presence of lymphoid follicles, stromal nevomelanocytic component, intraepithelial nevomelanocytic component, epithelial inclusions, quantity of goblet cells in epithelial inclusions, cellular atypia, mitoses and maturation of the lesion) were evaluated by three independent observers. Statistical analysis was performed comparing the two age groups.ResultsThe study determined a significant predominance of the lymphocytic and eosinophilic infiltration in the group of patients aged thirty years or less respect to the elderly group. The percentage of stromal component of the lesion is larger in patients over thirty years compared to the younger group. There was no correlation between epithelial inclusions, maturation or cytological atypia and age groups.ConclusionWe found some histopathological differences in conjunctival nevi related to young age, some of them coincident with the ones described in IJCN, which histopathologically could lead to a misleading diagnosis. However, we did not find significant differences related to age in many of the described histopathological findings described in IJCN. Larger series with a greater number of cases would be of interest to characterize more precisely this lesion.

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…This neoplasm appears most frequently in the bulbar conjunctiva (72%) [2]. Progression to melanoma has only been described in 1% of cases [3].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Search for histopathological characteristics of inflammatory juvenile conjunctival nevus in conjunctival nevi related to age: Analysis of 33 cases

Nebot

Sáez

Serret

et al. 2019

Saudi Journal of Ophthalmology

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Clinical profile of melanocytic lesions of the ocular surface in a Hispanic population

et al. 2022

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Oral Mucosal Lesions in Childhood

et al. 2022

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Childhood diseases are a continuous source of interest in all areas of general and dental medicine. Congenital, developmental, and hereditary diseases may either be present upon birth or appear in early childhood. Developmental anomalies, although often asymptomatic, may become grounds for different infections. Furthermore, they can indicate certain systemic disorders. Childhood age frequently brings about benign tumors and different types of traumatic lesions to the oral mucosa. Traumatic lesions can be caused by chemical, mechanical, or thermal injury. Mucocele and ranula are, by definition, traumatic injuries of the salivary glands or their ducts. Recurrent aphthous lesions are the most common type of ulcerations in childhood, and their etiology is considered multifactorial. Oral mucosal lesions in children require different treatment approaches depending on etiological factors and clinical presentation. Clinicians should have adequate knowledge of oral anatomy in order to diagnose and treat pathological conditions.

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Nevus compuesto inflamatorio juvenil: no es melanoma todo lo que parece

Cited by 4 publications

References 9 publications

Search for histopathological characteristics of inflammatory juvenile conjunctival nevus in conjunctival nevi related to age: Analysis of 33 cases

Search for histopathological characteristics of inflammatory juvenile conjunctival nevus in conjunctival nevi related to age: Analysis of 33 cases

Clinical profile of melanocytic lesions of the ocular surface in a Hispanic population

Oral Mucosal Lesions in Childhood

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