2011
DOI: 10.4061/2011/105973
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Nevus Lipomatosus Superficialis with a Folliculosebaceous Component: Report of 2 Cases

Abstract: Nevus lipomatosus superficialis (NLS) is an uncommon hamartomatous lesion of the skin characterized by the presence of clusters of mature fat cells among the collagen bundles of the dermis. Usually, the number of adnexal structures is reduced in NLS as compared to the normal adjacent skin, but their morphology is not altered. Nevertheless, in some instances, associated pilar abnormalities have been reported. We here report 2 cases of NLS with disorganized pilosebaceous units. The follicular structures were dil… Show more

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Cited by 31 publications
(36 citation statements)
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“…4,7,8 Secondary calcinosis resulting from dystrophic calcification in an NLCS lesion has not been previously reported. 4,7,8 Secondary calcinosis resulting from dystrophic calcification in an NLCS lesion has not been previously reported.…”
Section: Discussionmentioning
confidence: 95%
“…4,7,8 Secondary calcinosis resulting from dystrophic calcification in an NLCS lesion has not been previously reported. 4,7,8 Secondary calcinosis resulting from dystrophic calcification in an NLCS lesion has not been previously reported.…”
Section: Discussionmentioning
confidence: 95%
“…These differences made the diagnosis of NLS less certain; however, the presence of follicular or sebaceous structures has been reported in NLS. 4,6 The differential diagnoses in this patient included nevus sebaceous, fibroepithelial polyps, connective tissue nevus, neurofibroma, lymphangioma, hemangioma, tuberous xanthoma, fibrous histiocytoma, or focal dermal hypoplasia (Goltz syndrome). Of these, Goltz syndrome also shows segmental or Blaschko's line distribution.…”
Section: Dear Editormentioning
confidence: 98%
“…While the relationship between NLCS and trichofolliculoma or FCH remains unclear, this association of two distinct hamartomatous disorders suggests epidermal structures as part of NLCS. [234] The discovery of a case of NLCS with follicular papules and hypertrophic pilo-sebaceous units supports this possibility.…”
mentioning
confidence: 99%
“…A peculiar histopathological finding was the association with trichofolliculoma, a hamartoma of pilosebaceous follicles manifesting as small nodules with protruding tufts of hair primarily on the scalp, face, and neck. While we found no other report of the association of NLCS and trichofolliculoma, there have been four NLCS cases associated with folliculosebaceous cystic hamartoma (FCH),[234] a rare cutaneous hamartoma containing follicular, sebaceous, and mesenchymal elements such as ectodermal and mesodermal components.…”
mentioning
confidence: 99%