New 1,2,4‐Triazine‐Containing Podands: Synthesis and Properties.

Abstract

New 1,2,4-Triazine-Containing Podands: Synthesis and Properties. -The synthesis as well as Ca 2+ and Mg 2+ extraction and transport properties through an organic membrane are reported for a series of podands (I) carrying 1,2,4-triazine moieties. -(CHUPAKHIN*, O. N.; RUSINOV, G. L.; ITSIKSON, N. A.; BERESNEV, D. G.; FEDOROVA, O. V.; OVCHINNIKOVA, I. G.; Russ.

Synthesis, spectroscopic characterization of new heterocycles based on sulfamethoxazole as potent antimicrobial agents

“…The reaction mixture then reflexed about (8-10 hrs.). The separated solid was filtered, dried and recrystallized from mixed solvents ethanolwater (1:1) for compound (14)dioxane for compounds (15,17) and chloroform forcompound ( 16) respectively to yield favorites oxazepine products. [19] 2.11.…”

“…Antimicrobial study. In order to measure antibacterial activity of newly prepared compounds (3)(4)(5)(6)(7)(8), (14)(15)(16)(17), a plate of two type of Gram positive bacterial strains [Enterococcus faecalis (EF),Staphylococcus aureus (SA)] and two type of Gram negative bacterial strains [Pseudomonas aeruginosa (PA), Klebsiella pneumonia (KP)]. The antifungal activity was assayed against two type of pathogenic yeast like fungi [Aspergillus niger (AN), Candida albicans (CA)].The activities were evaluatedin vitro using the agar disc diffusion method.…”

“…The inhibition zone of the newly synthesized sulfamethoxazole derivatives (3)(4)(5)(6)(7)(8) and (14)(15)(16)(17) were observed and measured. The antibacterial activities of these compounds were performed against some types of pathogenic bacterial isolates while antifungal activities are evaluated against some yeast similar to fungi.The obtained results of these study are summarized in Table - The results showed that several of the synthesized sulfamethoxazole derivatives displayed notable antimicrobial activity.…”

“…Some of the novel derivatives are superior to parent sulfamethoxazole for their antifungal activity especially compounds (6,7 and 14-17). In general, the compounds designed based on a sulfamethoxazole with 1,3-oxazepines skeleton (compounds [14][15][16][17] are further active than those obtained from other sulfamethoxazole with heterocycles analogues.…”