New 1,3,4-thiadiazole compounds including pyrazine moiety: Synthesis, structural properties and antimicrobial features

Gür, Mahmut; Şener, Nesrin; Muğlu, Halit; Çavuş, M. Serdar; Özkan, Osman Emre; Kandemirli, Fatma; Şener, İzzet

doi:10.1016/j.molstruc.2017.03.019

Cited by 24 publications

(12 citation statements)

References 11 publications

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“…The disks were maintained at room temperature for 24 h under aseptic conditions. Microorganism suspensions (0.5 McFarland) were inoculated on the surfaces of the Mueller–Hinton agar plates, which remained under aseptic conditions for 5 min before applying the disks, as described in previous studies . After 24 h, the zone of inhibition, including the disk, was measured, and the zone diameters were measured in millimeter.…”

Section: Methodsmentioning

confidence: 99%

Synthesis, Characterization, and Antimicrobial Properties of New 1,3,4‐Thiadiazoles Derived from Azo Dyes

Gür

2019

Journal of Heterocyclic Chem

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Some new 1,3,4‐thiadiazoles derived from azo dyes were synthesized. Two different synthesis methods were used for these compounds: Esters pertaining to the azo dyes were converted into 1,3,4‐thiadiazoles, or benzothiazole ester derivatives were converted to 1,3,4‐thiadiazoles followed by the synthesis of azo dye derivatives. The desired products were successfully obtained using the latter method. The molecular structures of these compounds were characterized using spectroscopic methods such as FTIR, 1H NMR, 13C NMR, and elemental analysis. Furthermore, antimicrobial activity was studied for the synthesized compounds. Compound 3e exhibited antimicrobial activity against three different microorganisms. Compounds 3a, 3b, and 3d had activity against two different microorganisms, while compound 3c showed activity against only one microorganism.

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Section: Methodsmentioning

confidence: 99%

Synthesis, Characterization, and Antimicrobial Properties of New 1,3,4‐Thiadiazoles Derived from Azo Dyes

Gür

2019

Journal of Heterocyclic Chem

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“…1,3,4thiadiazole is the most widely studied isomer. It has been converted into many different derivatives in order to synthesize five-membered heterocyclic compounds with different properties [3,4]. Its derivatives have several applications in antimicrobial [5], anticancer [6,7], antipsychotic [8], antitubercular [9], antihistamine [10], anticonvulsant [11], anti-inflammatory [12], anti-leishmanial [13], anti-hepatitis B [14], anti-Parkinson [15], and anti-diabetic [16] fields.…”

Section: Introductionmentioning

confidence: 99%

“…The resulting solid was purified by dissolving in DMSO and re-precipitated from ethanol. The physical properties are listed in Table- [30 ] : (4) Acid hydrazide (0.01 mol) was suspended in absolute ethanol(30 ml) placed in a round-bottom flask(100 ml), then potassium hydroxide (0.01 mol, 0.56 gm) and carbon disulphide (0.01 mol, 0.60 ml) were added respectively with continues stirring. The mixture was stirred under reflux for 1 hr.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Novel Subs. -1,3,4-Thiadiazolependant on Modified Poly(5-Vinyl Tetrazole-Co-MA)

Hamid

Obaid

2020

eijs

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New polymers were prepared from a monomer (5-vinyl-1H-tetrazole), which was prepared from acrylonitrile with sodium azide in the presence of ZnCl2.Another monomer (Methyl acrylate) was also used. Co-monomers were polymerized usingBPO as initiator. The second step was the preparation of copoly acid hydrazide from the reaction of compound2 with hydrazine hydrate, followed by the reaction with carbon disulphide in the presence of KOH to obtain copoly (5-subs.-2mercapto-1,3,4-thiadiazole). Next,compound4 was reacted with chloroacetyl chloride to yield compound4 5 which was reacted with (hydrazine hydrate , phenyl hydrazine and 2,4-di nitro phenyl hydrazine) as shown in scheme(1). Physical properties of all the prepared copolymers were characterized by FT-IR and, in certain cases,by1HNMR spectroscopy.

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“…1,3,4-Tiyadiazol en çok çalışılan izomerdir. Farklı özelliklere sahip beş üyeli heterosiklik bileşiklerin sentezlenmesi için birçok farklı türeve dönüştürülmüştür [1,2]. Farklı özelliklere sahip beş üyeli heterosiklik bileşiklerin sentezlenmesi için literatürde birçok farklı yöntem yayınlanmıştır [1,2].…”

Section: Introductionunclassified

5-Merkapto-2-(3-metil-tiyofen-2-il-metilidenamino)-1,3,4-tiyadiazol Bileşiğinin Sentezi, Karakterizasyonu ve DFT Hesaplamaları

Beytur

Akyıldırım

Yokuş

2019

Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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Özet: 5-Merkapto-2-(3-metil-tiyofen-2-il-metiliden-amino)-1,3,4-tiyadiazol bileşiği sentezlenmiş ve IR, 1 H-NMR ve 13 C-NMR spektroskopik yöntemleri ile karakterize edilmiştir. Sentezlenen bileşiğin geometrik optimizasyonu Gaussian G09W yazılımı kullanılarak DFT/B3LYP yöntemi ve 6-311G+(d,p) temel seti yapılmıştır. Elde edilen optimize yapıdan molekülün geometrik yapıları, titreşim dalga sayıları, 1 H ve 13 C nükleer manyetik rezonans kimyasal kayma değerlerinin kuantum kimyasal hesaplamaları elde edilmiştir. Bu değerler ile deneysel spektroskopik değerler karşılaştırılmıştır. Teorik değerlerin deneysel değerleri desteklediği gözlemlenmiştir. İlaveten, ilgili bileşiğin, çizgisel olmayan optik özellikleri; tek nokta enerji hesabında polar hesapları yapılarak polarizebilite ve hiperpolarizebilite değerleri hesaplanmıştır. Son olarak, Mulliken atomik yükleri, HOMO-LUMO enerjileri, dipol momentleri, toplam enerjileri, iyonlaşma potansiyeli, elektron ilgisi, moleküler yumuşaklık, moleküler sertlik ve elektronegatifliği aynı metotlar ve aynı set kullanılarak hesaplanmıştır.

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New 1,3,4-thiadiazole compounds including pyrazine moiety: Synthesis, structural properties and antimicrobial features

Cited by 24 publications

References 11 publications

Synthesis, Characterization, and Antimicrobial Properties of New 1,3,4‐Thiadiazoles Derived from Azo Dyes

Synthesis, Characterization, and Antimicrobial Properties of New 1,3,4‐Thiadiazoles Derived from Azo Dyes

Synthesis and Characterization of Novel Subs. -1,3,4-Thiadiazolependant on Modified Poly(5-Vinyl Tetrazole-Co-MA)

5-Merkapto-2-(3-metil-tiyofen-2-il-metilidenamino)-1,3,4-tiyadiazol Bileşiğinin Sentezi, Karakterizasyonu ve DFT Hesaplamaları

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