13During periods of strong environmental change, some areas may serve as refugia, where components of 14 biodiversity can find protection, persist and potentially expand from should conditions again become 15 favourable. The refugia concept has previously been used in the context of climatic change, to describe 16 climatically stable areas in which taxa survived past Quaternary glacial-interglacial oscillations, or where they 17 might persist in the future under anthropogenic climate change. However, with the recognition that Earth 18 has entered the Anthropocene, an era in which human activities are the dominant driving force on 19 ecosystems, it is critical to also consider human pressures on the environment as factors limiting species 20 distributions. Here, we present a novel concept, Anthropocene refugia, to refer to areas that provide spatial 21 and temporal protection from human activities and that will remain suitable for a given taxonomic unit in 22 the long-term. It integrates a deep-time perspective on species biogeography that provides information on 23 the natural rather than current-day relictual distribution of species, with spatial information on modern and 24 future anthropogenic threats. We define the concept and propose a methodology to effectively identify and 25 map realised and potential current and future refugia, using examples for two megafauna species as a proof 26 of concept. We argue that identifying Anthropocene refugia will improve biodiversity conservation and 27 restoration by allowing better prediction of key areas for conservation and potential for re-expansions today 28 and in the future. More generally, it forms a new conceptual framework to assess and manage the impact of 29 anthropogenic activities on past, current and future patterns of species distributions. 30 31