New 18(4→3)-Abeo-Abietanoids from Tripterygium wilfordii

Abstract

Three 18(4→3)-abeo-abietanoids, a new natural product and two new compounds, named tripordolides A–C (1–3), were isolated from the leaves of Tripterygium wilfordii. Their structures were elucidated on the basis of their spectroscopic analysis, and the absolute configuration of compounds was confirmed by CD and X-ray crystallographic analysis using anomalous scattering of Cu Kα radiation. Compounds 1 and 3 showed moderate inhibitory activities against NO production in lipopolysaccharide-induced (LPS) RAW 264.7 macrophages in vitro.

Natural epoxyquinoids: isolation, biological activity and synthesis. An update

“…Previously unknown tripordolide C was isolated from the leaves of Tripterygium wilfordii . 126 Tripordolide C was evaluated for its in vitro inhibitory activities against NO production in lipopolysaccharide-induced RAW 264.7 macrophages. Tripordolide C showed moderate inhibition of NO production in mouse peritoneal macrophage at a concentration of 10 μM.…”

“…Previously unknown tripordolide C was isolated from the leaves of Tripterygium wilfordii. 126 Tripordolide C was evaluated for its in vitro inhibitory activities against NO production in lipopolysaccharide-induced RAW 264.7 macrophages.…”