New 2-aminopyrimidine derivatives and their antitrypanosomal and antiplasmodial activities

Abstract

Novel 2-aminopyrimidine derivatives were prepared from acyclic starting materials, benzylidene acetones and ammonium thiocyanates, via 5 steps, including ring closure, aromatization, S-methylation, oxidation to methylsulfonyl compounds, and formation of guanidines with suitable amines. The prepared compounds differ from each other by the substitutions of their amino group and of their phenyl ring. The 2-aminopyrimidines were tested by use of microplate assays for their in vitro activities against a causative organism of sleeping sickness, Trypanosoma brucei rhodesiense, as well as against a causative organism of malaria, Plasmodium falciparum NF54. Their cytotoxic properties were determined with L-6 cells (rat skeletal myoblasts). Some of the compounds exhibited quite good antitrypanosomal activity, and others showed excellent antiplasmodial activity. The influence of the structural modifications on these activities is discussed. Graphic abstract

Pyrrole–Aminopyrimidine Ensembles: Cycloaddition of Guanidine to Acylethynylpyrroles

“…The aminopyrimidine ring is a fragment of nucleotide bases in DNA and RNA, which are important components of living cells [ 4 ]. Substituted 2-aminopyrimidines exhibit cardiotonic [ 6 ], antitrypanosomal and antiplasmodial [ 7 ], antimicrobial [ 8 , 9 , 10 , 11 ] and antiplatelet aggregation activity [ 12 ]. They are also ligands of histamine H 4 and H 3 receptors [ 13 , 14 ], inhibitors of IRAK4 (interleukin-1 receptor-associated kinase 4) [ 15 ], the vascular endothelial growth factor inhibitor [ 16 ], serine/threonine protein kinase inhibitors, candidates for treating drug-resistant tuberculosis [ 17 ].…”