New 3D Supramolecular Ag(I) Coordination Polymer Crystal Containing 2‐Quinaldic Acid Radical Biological Ligand: Crystal Structure and Anticancer Activity

Abstract

A new coordination polymer of {[Ag(Qina)(Bpp)]·(H 2 O) 2 } n (Qina =2-quinolinecarboxylic-carboxylate, Bpp = 4,4'-trimethylenedipyridine) is successfully synthesized and the structure is determined using single crystal X-ray diffraction. The complex is crystallized in the monoclinic system with P2 1 /c space group: Each atom of Ag(I) is chelated by one Qina group, with each Bpp ligand bridging two Ag(I) atoms to form the 1D polymer chains. Furthermore, the 3D supramolecular architecture is a costructure directed via weak stacking interactions of C-H···π and hydrogen bond. The complex shows competitive binding affinities in calf thymus DNA (ct-DNA) interaction by fluorescence spectroscopy. In addition, the complexes' cytotoxic activity is explored for two kinds of cancer cell lines (Hela, MCF-7), indicating an anticancer activity and cytotoxicity. CCDC: 1553426 Experimental Section Materials and InstrumentsAll reagents and solvents used in experimental and tests are commercially available and directly used without any treatment. As for characterizations, a model Finnigan EA 1112 was employed for Elemental analyses (including C, H, and N); and a Thermo Nicolet 380 FT-IR spectrophotometer for IR analysis by KBr disks method; a Bruker SMART APEX2 CCD diffractometer (Mo Kα, λ = 0.71073Å) for polymorphism analysis by single-crystal X-ray diffraction; as well as a Perkin-Elmer LS55 fluorescence spectrofluorimeter for emission spectrum.

Coumarin Derivative Induced 3D Organo‐Silver(I) Complex with Tandem Hydrazine Detection and 4‐Nitrophenol Catalysis

“…[36][37][38] Besides the fascinating crystal structures, the new functions of the 3D silver(I) clusters are also an urgent pursue in the field of cluster chemistry. [39][40][41][42] For the 3D silver(I) cluster based compounds, each silver(I) ion is entrapped in a tightly packed framework, thus it can release the silver(I) ions gradually. As such, the sustained release of Ag + allows the cluster to explore the reactions of the oxidized silver(I) ion with reductive molecules.…”

Heterometallic coordination polymers: Treatment activity on diabetic foot by reducing the excess inflammatory response in the plantar tissue

“…[5][6][7][8] The increasing interest in this field is justified not only by their valuable structures, but also their potential applications in luminescence, catalysis, and biochemistry, and particularly in modern medicinal chemistry. [9][10][11][12][13][14][15] Among the series of compounds fabricated, functional complexes attract great attention due to their potentially valuable drug applications. Metal complexes, particularly those containing sp 2 hybrid nitrogens as part of the aromatic system of the ligands, find significant applications as drugs.…”

Retracted: A New Cu(I)‐Based Coordination Polymer: Crystal Structure, Molecular Docking and Protective Effect in Streptococcus‐pneumoniae‐Infected Mice by Promoting Immune Cell Response

“…From these properties, many latent applications can be inferred, including molecular separation, gas storage, sensing and chemical catalysis, drug delivery as well as ion exchange . Coordination compounds can be utilized as anticancer agents . Many Cu(I)‐based coordination polymers have been found and reported as the latent anticancer drugs, which are more active than platinum drugs in vitro and in vivo.…”