New 3β-hydroxysteroid-indolamine conjugates: Design, synthesis and inhibition of C6 glioma cell proliferation

Panada, J. U.; Klopava, V A; Kulahava, Tatsiana; Frolova, N. S.; Faletrov, Yaroslav V.; Shkumatov, V. M.

doi:10.1016/j.steroids.2020.108728

Cited by 4 publications

(2 citation statements)

References 62 publications

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“…Культивацию дрожжей Saccharomyces cerevisiae (штамм YEp5117α) осуществляли по методике, описанной в работе [8].…”

Section: материалы и методы исследованияunclassified

“…2). Однако в аналогичных условиях триптамин, не содержащий 3-ацетильной группы или 5-гидроксигруппы, уменьшает пролиферацию только на (21 ± 9) % [8]. Поскольку снижение пролиферации под действием 5-HIET не вызвано некрозом клеток, можно предполагать, что данный эффект обусловлен либо угнетением клеточного деления, либо индукцией гибели клеток по механизму апоптоза или аутофагии.…”

Section: результаты и их обсуждениеunclassified

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Influence of 3-acetyl-5-hydroxy-2-methylindole on glioma cell proliferation and metabolism

Panada¹,

Klopava²,

Kulahava³

et al. 2022

Journal of the Belarusian State University. Chemistry

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A 3-acetyl analogue of 5-hydroxyindole was synthesised and evaluated for its effects on rat C6 glioma cell functions. It was found that 3-acetyl-5-hydroxy-2-methylindole at 10 μmol/L led to a sharp reduction of mitochondrial membrane potential, induction of autophagy and decrease of proliferation of C6 glioma cells. The compound’s effect was comparable to that of rotenone, an inhibitor of cell respiration.

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“…Культивацию дрожжей Saccharomyces cerevisiae (штамм YEp5117α) осуществляли по методике, описанной в работе [8].…”

Section: материалы и методы исследованияunclassified

Section: результаты и их обсуждениеunclassified

Influence of 3-acetyl-5-hydroxy-2-methylindole on glioma cell proliferation and metabolism

Panada¹,

Klopava²,

Kulahava³

et al. 2022

Journal of the Belarusian State University. Chemistry

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Differential induction of C6 glioma apoptosis and autophagy by 3β-hydroxysteroid-indolamine conjugates

Panada,

Klopava,

Kulahava

et al. 2023

Steroids

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Influence of N-Alkynylaminosteroids on Mitochondrial Functioning and Autophagy in Glioma Cells

Panada

Klopava

Kulahava

et al. 2022

Biochem. Moscow Suppl. Ser. B

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New 3β-hydroxysteroid-indolamine conjugates: Design, synthesis and inhibition of C6 glioma cell proliferation

Cited by 4 publications

References 62 publications

Influence of 3-acetyl-5-hydroxy-2-methylindole on glioma cell proliferation and metabolism

Influence of 3-acetyl-5-hydroxy-2-methylindole on glioma cell proliferation and metabolism

Differential induction of C6 glioma apoptosis and autophagy by 3β-hydroxysteroid-indolamine conjugates

Influence of N-Alkynylaminosteroids on Mitochondrial Functioning and Autophagy in Glioma Cells

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