New 4-thiazolidinones from 5-ethyl pyridine-2-ethanol: their antibacterial, antifungal, and antitubercular activity

Patel, Navin B.; Patel, Hemant R.; Shaikh, Faiyazalam M.; Rajani, Dhanji P.

doi:10.1007/s00044-013-0736-8

Cited by 25 publications

(8 citation statements)

References 25 publications

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“…Thiazolidinone is a biologically important five-membered heterocyclic ring having two heteroatoms; a sulfur at position 1 and a nitrogen at position 3 along with a carbonyl group at positions 2, 4, or 5 [120]. Besides the relative thiazolidine-2,4-diones which bear two carbonyls on their ring, the five different forms of thiazolidinones exhibit a wide range of biological applications as antitubercular [121], antimicrobial [122], antiviral [123], and anticancer agents [124], making them an attractive structure for molecular hybridization.…”

Section: Thiazolidinone-pyrazoline Hybridsmentioning

confidence: 99%

Pyrazoline Hybrids as Promising Anticancer Agents: An Up-to-Date Overview

Matiadis

Sagnou

2020

IJMS

104

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Pyrazolines are five-membered heterocycles possessing two adjacent nitrogens. They have attracted significant attention from organic and medicinal chemists due to their potent biological activities and the numerous possibilities for structural diversification. In the last decade, they have been intensively studied as targets for potential anticancer therapeutics, producing a steady yearly rise in the number of published research articles. Many pyrazoline derivatives have shown remarkable cytotoxic activities in the form of heterocyclic or non-heterocyclic based hybrids, such as with coumarins, triazoles, and steroids. The enormous amount of related literature in the last 5 years prompted us to collect all these published data from screening against cancer cell lines, or protein targets like EGFR and structure activity relationship studies. Therefore, in the present review, a comprehensive account of the compounds containing the pyrazoline nucleus will be provided. The chemical groups and the structural modifications responsible for the activity will be highlighted. Moreover, emphasis will be given on recent examples from the literature and on the work of research groups that have played a key role in the development of this field.

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Section: Thiazolidinone-pyrazoline Hybridsmentioning

confidence: 99%

Pyrazoline Hybrids as Promising Anticancer Agents: An Up-to-Date Overview

Matiadis

Sagnou

2020

IJMS

104

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“…Patel et al. showed that compound 184 and 185 display more potency (MIC = 25 μg/mL) than standard drug rifampin (MIC = 40 μg/mL) . Hernández et al.…”

Section: Pyridinesmentioning

confidence: 99%

New structural classes of antituberculosis agents

Kumar

Patel

Jain

2017

Medicinal Research Reviews

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Tuberculosis (TB), one of the deadliest diseases is shattering the health and socioeconomic status of the society. The emergence of multidrug resistant (MDR) and extremely drug resistant (XDR) strains has provided unprecedented lethal character to TB. The development of MDR and XDR strains of TB results in more deaths, longer duration of therapy, and appearance of the disease in the immunocompromised patients. Because of the development of rapid resistance by Mycobacterium tuberculosis, researchers are confronted with serious challenges in combating TB. For instance, the need for potency and specificity in therapeutic agents approaching clinics, and the increasing demand of low toxicity due to long duration of treatment. Recently, it is proposed that such challenges could be addressed by a shift from contemporary or known classes of drugs to new scaffold-containing or entirely new structural classes of drugs that possibly act on the previously unknown targets, resulting in possibly less instances of resistance development. The exploitation of advances made in the biology of TB in the last and present decades have created opportunities to discover a large number of new structural classes that specifically targets TB by molecular mechanism of action(s) unknown earlier. We have earlier reviewed new structural classes of anti-TB agents up to year 2005. This review covers literature reports of the subsequent 10 years on the discovery of new structural classes of synthetic anti-TB agents. Due to the availability of large number of research reports, we have divided new compounds in 38 structural classes, 368 structures, and 307 references.

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“…Speci cally, ve-membered heterocycles with two heteroatoms have received particular attention, having proven utility in medicinal chemistry [31]. 1,3-Thiazolidin-4-ones are important class of compounds due to their biological pro les like anti-tubercular [32], anti-microbial [33], anti-in ammatory [34], anti-histaminic [35], anti-hepatitis [36], HIV inhibitors [37], anti-hyper-glycemic [38], anti-hypertensive [39], anti-convulsant [40], anti-fungal [41], anti-oxidant [42], and anti-proliferative [43] activity.…”

Section: Introductionmentioning

confidence: 99%

Application of a novel Deep Eutectic Solvent as a capable and new catalyst for the synthesis of tetrahydropyridines and 1,3-thiazolidin-4-ones

Goodarzi

Habibi

Monem

2023

Preprint

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A novel Deep Eutectic Solvent (ETPP-Br/THF-TCA-DES) was prepared by a mixture of ethyl triphenylphosphonium bromide (MTPP-Br) and tetrahydrofuran-2,3,4,5-tetra-carboxylic acid (THF-TCA, mole ratio 7:3) in a cheap, simple, and non-toxic method, characterized by FT-IR, TGA/DTA, densitometer, eutectic point, and 1H NMR techniques and used as a capable and new catalyst for the synthesis of two sets of compounds: i) the four new [a(1-4)] and the ten [a(5-15)] known alkyl 1,2,6-trisubstituted-4-[(hetero)arylamino]-1,2,5,6-tetrahydropyridine-3-carboxyl-ates, and ii) the two new [b(1-2)] and the eight [b(3-10)] known 1,3-thiazolidin-4-ones in solvent-free conditions, short reaction time, high yields, and easy recycling and separation of the DES catalyst. There is a nice consistency between the proposed structure of the DES compound, the integration values of the 1H NMR peaks and the ratio of ETPP-Br to THF-TCA obtained from the eutectic point phase diagram. Also, the decrease in splitting patterns of the peaks in DES, compared to the two starting materials can be a good evidence of hydrogen bond formation between the two components.

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New 4-thiazolidinones from 5-ethyl pyridine-2-ethanol: their antibacterial, antifungal, and antitubercular activity

Cited by 25 publications

References 25 publications

Pyrazoline Hybrids as Promising Anticancer Agents: An Up-to-Date Overview

Pyrazoline Hybrids as Promising Anticancer Agents: An Up-to-Date Overview

New structural classes of antituberculosis agents

Application of a novel Deep Eutectic Solvent as a capable and new catalyst for the synthesis of tetrahydropyridines and 1,3-thiazolidin-4-ones

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