New Accelerator Facility for Carbon-Ion Cancer-Therapy

Noda, K.; Furukawa, Takuji; Fujisawa, Takashi; Iwata, Y.; Kanai, Tatsuaki; Kanazawa, M.; Kitagawa, A.; Komori, Masataka; Minohara, Shinichi; Murakami, Takeshi; Muramatsu, M.; Sato, Shinji; Takei, Yasuhiko; Tashiro, Mitsuru; Torikoshi, M.; Yamada, S.; Yusa, K.

doi:10.1269/jrr.48.a43

Cited by 71 publications

(27 citation statements)

References 16 publications

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“…We have been developing a respiratory-gated pencilbeam scanning treatment [22,23] by extending the capability of the existing HIMAC (Heavy-Ion Medical Accelerator in Chiba) facility. The respiratory-gated scanning should consider multiple time axes, such as respiration (period, amplitude), beam irradiation, and accelerators.…”

Section: Discussionmentioning

confidence: 99%

Water-equivalent pathlength reproducibility due to respiratory pattern variation in charged-particle pancreatic radiotherapy

Kumagai

Mori²,

Hara³

et al. 2009

Radiol Phys Technol

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We evaluated the water-equivalent length (WEL) reproducibility due to variation in the external respiratory marker position when using a 4DCT scan in respiratory-gated charged-particle treatment. Two sets of pancreatic 4DCT data from two patients were acquired under free breathing conditions with 256-slice CT. The 4DCT data included two exhalation phases and the respiratory patterns in each patient differed, one being regular and the other irregular. The WEL calculation region is defined in the first respiratory cycle by two planes, one at the patient entrance surface and the other behind the target in the anterior-posterior (AP) and posterior-anterior (PA) directions. In the regular respiratory pattern, the WEL variation within the target region was less than 1.7 mm between the first and second exhalations in both AP and PA calculation directions. However, in the irregular breathing pattern, the respiratory amplitude at the second exhalation was 20% lower than that at the first exhalation; therefore, WEL variations from 8.1 to -9.1 mm and from 3.1 to -3.4 mm were observed within the target region in the AP and PA calculation directions, respectively. The WEL variation in the PA direction was smaller than that in the AP direction because the abdominal thickness is affected more in the AP direction. Respiratory pattern variation even affects WEL values in the respiratory-gated phase. This variation should be considered in treatment planning, and necessary improvements in respiratory reproducibility should be made.

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Section: Discussionmentioning

confidence: 99%

Water-equivalent pathlength reproducibility due to respiratory pattern variation in charged-particle pancreatic radiotherapy

Kumagai

Mori²,

Hara³

et al. 2009

Radiol Phys Technol

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“…The specific technique of CIRT used at NIRS has been described in detail in previous publications [1][2][3][4][5][6][7][8]. Briefly, patients were positioned in a customised cradle and immobilised with a low-temperature thermoplastic sheet.…”

Section: Carbon Ion Radiotherapy For Sacral Chordomamentioning

confidence: 99%

“…Subsequently, two other facilities started to offer CIRT: in 1997 a facility opened at the Gesellschaft fü r Schwerionenforschung (GSI) in Darmstadt, Germany; in 2004, another opened at the Hyogo Ion Beam Medical Centre in Hyogo, Japan; and finally in 2006 an accelerator opened at the Institute of Modern Physics Lanzhou in China [3]. In 2005, the NIRS succeeded in developing a synchrotron that is smaller than the HIMAC and designed to make CIRT more widely available [4].…”

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confidence: 99%

Carbon ion radiotherapy for sacral chordoma

Imai¹,

Kamada²,

Sugahara³

et al. 2011

BJR

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ABSTRACT. The National Institute of Radiological Sciences in Chiba, Japan has offered carbon ion radiotherapy (CIRT) since 1994 using carbon ion beams generated by the heavy ion medical accelerator in Chiba (HIMAC). The total number of cases treated with the HIMAC exceeded 5000 in July 2009. Here, we present a retrospective analysis of CIRT for sacral chordoma. The study included 95 patients with medically unresectable sacral chordomas treated between 1996 and 2007. The median age of the patients was 66 years. Of all the patients, 84 had not been treated previously and 11 had a locally recurrent tumour following previous resection. The carbon ion dose ranged from 52.8 to 73.6 GyE (median 70.4 GyE) in a total of 16 fixed fractions over 4 weeks. The median clinical target volume was 370 cm 3 . The overall survival rate at 5 years for all 95 patients was 86%, and follow-up survival time was 42 months (range, 13-112 months). The 5-year local control rate was 88% and median time to local failure was 35 months (range, 13-60 months). Of the 95 patients, 91% remained ambulatory with or without a supportive device. Two patients experienced severe skin or soft tissue complications requiring skin grafts. 15 patients experienced severe sciatic nerve complications requiring continuing medication. CIRT appears effective and safe in the management of patients with sacral chordoma and offers a promising alternative to surgery.

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“…Here, we arbitrarily supposed that a minimum gap of 15 cm is required. In a new accelerator facility being planned in the Heavy Ion Medical Accelerator in Chiba (HIMAC) at National Institute of Radiological Sciences, for example, the maximum field of irradiation planned is 22 cm in diameter [12]. The distance between the iso-center and the face of the beam port planned is about 60 cm.…”

Section: Discussionmentioning

confidence: 99%

Imaging simulations of an “OpenPET” geometry with shifting detector rings

Yamaya¹,

Inaniwa²,

Mori³

et al. 2009

Radiol Phys Technol

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We have proposed a new "OpenPET" geometry consisting of two detector rings of axial length W each separated by a gap G. For obtaining an axially continuous field of view (FOV) of 2W + G, the maximum limit for G must be W. However, two valleys of sensitivity appear on both sides of the gap. Setting a more limited range for the gap as G < W, which is desirable for filling in the sensitivity valleys, results in not only a shortened gap, but also a shortened axial FOV. In this paper, we propose an alternative method for improving the uniformity of sensitivity by shifting two detector rings axially closer or further apart at the same velocity to each other. In addition, image reconstruction of the OpenPET is an incomplete problem, and low-frequency components are missing in the gap. Therefore, the proposed method is also expected to improve the conditions for the inverse problem. We simulated an OpenPET scanner which measures events simultaneously by shifting the detector rings. The results showed that the right and left peaks of the sensitivity approach each other upon shifting of the detector rings, and these valleys of sensitivity are effectively recovered. The results also showed that distortion, which is observed for objects containing low-frequency components, is reduced. Larger detector shifts allow a more uniform axial distribution of sensitivity and a higher image quality, but at the cost of a smaller minimum gap. Therefore, an appropriate detector-shifting pattern should be determined based on the desired scanner application.

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New Accelerator Facility for Carbon-Ion Cancer-Therapy

Cited by 71 publications

References 16 publications

Water-equivalent pathlength reproducibility due to respiratory pattern variation in charged-particle pancreatic radiotherapy

Water-equivalent pathlength reproducibility due to respiratory pattern variation in charged-particle pancreatic radiotherapy

Carbon ion radiotherapy for sacral chordoma

Imaging simulations of an “OpenPET” geometry with shifting detector rings

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