2021
DOI: 10.3390/molecules26030688
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New Acetophenones and Chromenes from the Leaves of Melicope barbigera A. Gray

Abstract: The dichloromethane extract from leaves of Melicope barbigera (Rutaceae), endemic to the Hawaiian island of Kaua’i, yielded four new and three previously known acetophenones and 2H-chromenes, all found for the first time in M. barbigera. The structures of the new compounds obtained from the dichloromethane extract after purification by chromatographic methods were unambiguously elucidated by spectroscopic analyses including 1D/2D NMR spectroscopy and HRESIMS. The absolute configuration was determined by modifi… Show more

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Cited by 5 publications
(6 citation statements)
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“…Subsequently, all of the isolated compounds underwent evaluation for their cytotoxic activities against the A2780 human ovarian cancer cell line. Notably, melibarbinon B and melibarbichromen B exhibited cytotoxic activities, displaying IC 50 values of 30.0 µM and 75.7 µM, respectively, in a nuclear shrinkage cytotoxicity assay and cisplatin was used as a positive control in this study [48].…”
Section: Lysimachia Genusmentioning
confidence: 99%
“…Subsequently, all of the isolated compounds underwent evaluation for their cytotoxic activities against the A2780 human ovarian cancer cell line. Notably, melibarbinon B and melibarbichromen B exhibited cytotoxic activities, displaying IC 50 values of 30.0 µM and 75.7 µM, respectively, in a nuclear shrinkage cytotoxicity assay and cisplatin was used as a positive control in this study [48].…”
Section: Lysimachia Genusmentioning
confidence: 99%
“…The acetophenones were melibarbinon A and melibarbinon B while the three chromenes were boesenbergin A, melibarbichromen B, and alloevodionol. [12] Melibarbichromen B exhibited an IC 50 of 30 μM (NSA assay) and > 100 μM (MTT assay) towards ovarian (A2780) cancer cells. [31] 2.9.…”
Section: Melicope Triphylla (Merr)mentioning
confidence: 99%
“…Phytochemical screening on dichloromethane extract of M. barbigera species successfully yielded two acetophenones and three chromenes. The acetophenones were melibarbinon A and melibarbinon B while the three chromenes were boesenbergin A, melibarbichromen B, and alloevodionol [12] . Melibarbichromen B exhibited an IC 50 of 30 μM (NSA assay) and >100 μM (MTT assay) towards ovarian (A2780) cancer cells [31] …”
Section: Melicope Species and Their Chemical Constituentsmentioning
confidence: 99%
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