New Acridizinium Salts Derived from [2-(Bromomethyl)phenyl]carbonyl Compounds

The benzo[b]quinolizinium ion as a water-soluble platform for the fluorimetric detection of biologically relevant analytes

“…This cyclodehydration method represents a widely applicable and efficient method that has been used for the synthesis of numerous derivatives. 35,43,44 Nevertheless, in some cases the regioselectivity of the ring closure cannot be controlled or particular regioisomers are only available in very low yields, so that other approaches were proposed. For example, 10-substituted benzo[b]quinolizinium derivatives, that are not accessible by the cyclodehydration route, may be obtained from 2-(hydroxymethyl)phenyl-2-pyridyl methanol by in-situ formation of the corresponding chloride with phosphoryl chloride and subsequent cyclization (Scheme 2, route 2).…”