New acrylic microspheres for arterial embolization: Combining radiopacity for precise localization with immobilized thrombin to trigger local blood coagulation

Saralidze, Ketie; Hooy-Corstjens, Catharina S. J. van; Koole, Léo H.; Knetsch, Menno L. W.

doi:10.1016/j.biomaterials.2006.12.031

Cited by 54 publications

(43 citation statements)

References 32 publications

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“…For all formulations containing IPEGA, the rate constants began at their highest point before declining as sterics, cross-linking density, and network formation impeded any further reaction. Higher levels of IPEG greatly increased the initial rate constant from 0.0029 to 0.0187 (M s) 21 from the 10% to 50% IPEGA formulations, respectively. There is a unique behavior of the second order rate constant in the 0% IPEGA gel formulation (purely PPODA/QT/Buffer).…”

Section: Rheologymentioning

confidence: 96%

“…It is possible to monitor the consumption of acrylate in the chemical reaction by monitoring the disappearance of the infrared absorption band of the out of plane deformation of the C¼ ¼C bond around 800 cm 21 . 26 This was accomplished with an ATR FT-IR TGS detector (Nicolet Nexus 470), subject to anhydrous air purge at room temperature.…”

Section: Ftir Kineticsmentioning

confidence: 99%

“…To measure the amount of acrylate consumed during the gelation reaction, the area under the alkene (C¼ ¼C) acrylate peak (790-820 cm 21 , baseline 790-820 cm 21 ) was measured after mixing. To normalize the measurements for any fluctuations in signal intensity during the gelation, a reference measurement was made of the methyl peak (1360-1390 cm 21 , baseline 1360-1390 cm 21 ), present due to the methyl side groups in the PPODA backbone, since the concentration of methyl groups is unchanged by the MichaelType Addition gel forming reaction. The ratio of the acrylate peak area to the methyl peak area was then plotted as a function of time.…”

Section: Ftir Kineticsmentioning

confidence: 99%

“…Initially the contrasting agents used were inorganic salts added to polymers that had undesirable affects on material properties. 20 Since then, materials with radioopaque species, especially iodine, incorporated into the polymer backbone introduced intrinsically radio-opaque materials [21][22][23] with proven biocompatibility. 24 Our current research emerged through a desire to create a new chemical synthesis technique to adjoin intrinsic radio-opacity to the PPODA/QT in situ gelling material using a PEG-acrylate derivative reacted with 4-iodobenzoyl chloride.…”

Section: Introductionmentioning

confidence: 99%

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Formulation and characterization of radio‐opaque conjugated in situ gelling materials

et al. 2010

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X-ray visibility is an integral design component of in situ gelling embolization systems for neurovascular treatment. The goals of this project included the synthesis and characterization of a unique intrinsically radio-opaque in situ gelling material for neurovascular embolization. The gels formed using Michael-Type Addition between pentaerythritol tetrakis 3-mercaptopropionate (QT) thiols and poly(propylene glycol) diacrylate (PPODA) with the addition of the new material Iodobenzoyl poly(ethylene glycol) acrylate (IPEGA), a radio-opaque agent, synthesized successfully as confirmed with (1)H NMR. The PPODA and IPEGA were mixed using a syringe coupler with QT and buffer at pH 11 for 90 seconds. Gel mixes were weighed to provide equal molar thiols and acrylate groups, changing the present acrylate-bearing compounds wt % ratios from 100 PPODA: 0 IPEGA, 90:10, 80:20, 70:30, 60:40, 50:50, and 0:100. Formulations with 10% and above of IPEGA were X-ray visible. Rheology showed that increasing the amount of IPEGA decreased the storage. Kinetic FT-IR studies indicate that the amphiphilic nature of the PEG backbone increased the reaction rate of the phase segregated reactants. Second order reaction constant modeling showed a change in initial reaction rate from 0.0029 to 0.0187 (M sec)(-1) from the 10% to 50% IPEGA formulations respectively.

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Section: Rheologymentioning

confidence: 96%

Section: Ftir Kineticsmentioning

confidence: 99%

Section: Ftir Kineticsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Formulation and characterization of radio‐opaque conjugated in situ gelling materials

et al. 2010

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“…Intravenous injection of microspheres and inhalation are the possible administration routes for targeting drugs to the lungs. However, some studies have shown that microspheres with a particle diameter greater than 5 ìm could block blood capillaries and induce chronic obstructive pulmonary emphysema [58]. On the other hand, frequent inhalation may induce lung .brosis [59].…”

Section: Kidney and Lung Targeted Deliverymentioning

confidence: 99%

Chitosan Mediated Targeted Drug Delivery System: A Review

Patel¹,

Patel²,

Patel³

2010

J Pharm Pharm Sci

235

166

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-Chitosan has prompted the continuous movement for the development of safe and effective drug delivery systems because of its unique physicochemical and biological characteristics. The primary hydroxyl and amine groups located on the backbone of chitosan allow for chemical modification to control its physical properties. When the hydrophobic moiety is conjugated to a chitosan molecule, the resulting amphiphile may form self-assembled nanoparticles that can encapsulate a quantity of drugs and deliver them to a specific site of action. Chemical attachment of the drug to the chitosan throughout the functional linker may produce useful prodrugs, exhibiting the appropriate biological activity at the target site. Mucoadhesive and absorption enhancement properties of chitosan increase the in vivo residence time of the dosage form in the gastrointestinal tract and improve the bioavailability of various drugs. The main objective of this review is to provide an insight into various target-specific carriers, based on chitosan and its derivatives. The first part of the review is concerned with the organ-specific delivery system using chitosan and its derivatives. The subsequent section considers the recent developments of drug delivery carriers for cancer therapy with special focus on various targeting strategies. __________________________________________________________________________________________

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Pulmonary Targeting Crosslinked Cyclodextrin Metal–Organic Frameworks for Lung Cancer Therapy

Xiong

et al. 2020

Adv Funct Materials

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Lung cancer is a serious threat to human health with the highest morbidity and mortality; metastatic lung cancer accounts for a majority of cancerrelated deaths. Hence, there is considerable interest in developing efficient lung-targeted drug delivery systems to improve overall survival and quality of life of lung cancer patients. Based on the lung-targeting characteristics of cubic crosslinked cyclodextrin metal-organic framework (CDF) nanoparticles, this study shows the synthesis of a nanoplatform using RGD-functionalized CDF to co-deliver low-molecular-weight heparin (LMWH) and doxorubicin (DOX) for treatment of lung cancer. Rational design of the DOX-loaded RGD-CDF-LMWH nanoplatform (RCLD) is carried out. RCLD nanoparticles are efficiently targeted to lung tumors following intravenous administration; RCLD accumulation in the lung is 5.8 times greater than that in the liver. Moreover, RCLD inhibits migration and invasion of cancer cells in vitro and significantly diminishes lung tumor nodule count and area of spread in human A549 and murine B16F10 lung cancer models in vivo. Furthermore, RCLD does not show serum enzyme or histopathologic indicators of tissue damage or adverse hematologic effects. Therefore, the multiple antitumor activities of this novel RCLD nanoplatform, alongside its safety profile for normal tissues, strongly support its use for targeted treatment of lung cancer.

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New acrylic microspheres for arterial embolization: Combining radiopacity for precise localization with immobilized thrombin to trigger local blood coagulation

Cited by 54 publications

References 32 publications

Formulation and characterization of radio‐opaque conjugated in situ gelling materials

Formulation and characterization of radio‐opaque conjugated in situ gelling materials

Chitosan Mediated Targeted Drug Delivery System: A Review

Pulmonary Targeting Crosslinked Cyclodextrin Metal–Organic Frameworks for Lung Cancer Therapy

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