New Advancements in Inflatable Penile Prosthesis

Dinerman, Brian; Eid, J. François

doi:10.1016/j.sxmr.2020.09.007

Cited by 8 publications

(4 citation statements)

References 9 publications

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“…InhibiZone TM was shown to limit bacterial colonization, particularly from Staphylococcus ( 7 , 28 ). This came after testing in vitro , in animal models, and finally in clinical settings ( 24 ).…”

Section: Resultsmentioning

confidence: 99%

“…coli , Serratia spp., and Proteus mirabilis ( P . mirabilis ) were common secondary culprits ( 14 , 28 , 31 , 32 ). Contemporary literature shows a shift towards gram-negative and fungal species that may not be covered using traditional antibiotic strategies ( 28 , 32 ).…”

Section: Resultsmentioning

confidence: 99%

“…mirabilis ) were common secondary culprits ( 14 , 28 , 31 , 32 ). Contemporary literature shows a shift towards gram-negative and fungal species that may not be covered using traditional antibiotic strategies ( 28 , 32 ). The American Urological Association (AUA) has now added aminoglycosides in response to this shift in bacterial species ( 9 ).…”

Section: Resultsmentioning

confidence: 99%

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Addressing the need for preclinical study of penile prosthesis infection: a new animal model and narrative review

Shah,

Liu,

Machado

et al. 2024

Transl Androl Urol

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Background and Objective Erectile dysfunction (ED) is a common condition in men, and many patients refractory to conservative treatment may undergo penile prostheses (PPs) placement. The primary concern following PP implantation is device infection. Although antibiotic and hydrophilic coatings have reduced the incidence of inflatable PP (IPP) infections, there remains room for improvement. Optimization of PP outcomes requires a practical in vivo model to better understand mechanisms of infection and to test new infection control strategies. We aimed to describe a new rabbit model which contains a functional IPP and review previously reported animal PP models. Methods An IPP was placed into rabbit flanks and cycled for functionality testing. Rabbits were evaluated for signs of pain and distress over 14 days. Separately, narrative review methodology was utilized to search the PubMed and Scopus databases for all publications through March 21, 2023, which studied PP within an in vivo setting. Three independent reviewers ultimately selected 12 papers from 1992–2021 for inclusion. Key Content and Findings Several animal studies highlighted the initial functionality or feasibility of devices for ED before their introduction in the clinical setting. There are several subsequent studies aimed at optimizing the type of antibiotic use or coating material using segments of PP material in an in vivo setting. However, the literature lacks a contemporary animal model containing a functional IPP. Our novel rabbit model offers a safe, practical way to implant a functioning IPP and investigate new perioperative infection prevention and treatment strategies before trials in the clinical setting. Conclusions Animal models have played a key role in testing medical devices, including PPs, prior to their clinical introduction. Our review uncovered no modern animal studies involving placement of a functional PP. A new animal model can facilitate study of evolving microorganism profiles, novel methods to enhance antibiotic delivery, and proposed treatment options.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Addressing the need for preclinical study of penile prosthesis infection: a new animal model and narrative review

Shah,

Liu,

Machado

et al. 2024

Transl Androl Urol

View full text Add to dashboard Cite

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“…Since the 1980s, there have been notable improvements in the technological advancements pertaining to the design of 3-piece inflatable penile prostheses (IPPs), with a focus on enhancing concealability and optimizing surgical placement. In the last decade, notable progress has been made in the field, encompassing various enhancements such as updates to pumps, reservoirs, tubing, and cylinders [1].…”

Section: Introductionmentioning

confidence: 99%

The Management of Inflatable Penile Prosthesis Erosion and Infection following Iatrogenic Aspiration

Baydoun,

Benben,

Skalak

et al. 2024

Case Reports in Urology

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This case report presents a unique and previously unreported case of malfunction, infection, and erosion of an inflatable penile prosthesis (IPP) resulting from iatrogenic injury during a priapism aspiration procedure performed by an emergency medicine physician. The patient, a 75-year-old male with a history of IPP placement for erectile dysfunction, presented with urinary retention and priapism, leading to inadvertent deflation of the IPP during aspiration. Subsequent evaluation revealed a pinhole opening on the scrotum, indicating infection and erosion of the prosthesis tubing. The patient underwent emergent explantation of the infected IPP, washout, cystoscopy, and insertion of a suprapubic tube. Intraoperative cultures identified Escherichia cloacae as the causative pathogen. This case highlights the importance of thorough chart review to identify patients with IPPs before aspiration procedures and emphasizes the need for healthcare provider education regarding potential complications in this patient population. Early recognition and management of such complications are crucial for optimal patient outcomes. While IPP placement remains a highly satisfactory treatment for erectile dysfunction, this case highlights the importance of vigilance to ensure the best care for patients with penile prostheses. It is noteworthy that ultimately, a new IPP was not placed in this patient due to the patient’s significant medical comorbidities.

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